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Pak1

Victor ID 4758
Gene Name Pak1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii
NCBI Protein GI 18087341
Other Database IDs CDD:29038
CDD:186871
CDD:143851
CDD:173623
Taxonomy ID 178876
Gene Strand (Orientation) ?
Protein Name PAK1 kinase
Protein Length 632
Protein Note PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-; cd01093
Protein Sequence 
>gi|18087341|gb|AAL58841.1| PAK1 kinase [Cryptococcus neoformans var. grubii]
MEDVKMSGPVGVGVPMGVVEPREKELPHEPGSAAAMGGRSRSGTGRSSKDKKSMFGFVSDLLGKDKPPVI
SKPYDPVHVTHVGFDFQTGKYTGMPPKWQQVLDDNGITQDEQERNPNGVMAVVQYLKHQDEGEDEEEEIW
AKMKNAQPPALPAPPSAASSQPTTPGAGVMASREMSRETSNEALGPAGGQVVGDFTSPRMAPAPPTKPSL
NRMLSERHAPASHRPAELTTPAPLAGPPPAPRTTTQAYSPAPTHSPQHLSSHPGALPPPPPSAHAPAHAP
AHLDRSYSQRAPVSGTKTKLLDRANTTRSPGSSVGIAQGAGGSKGMAMGMGMGLTKSQSQSGHKSRERGD
PSREPKDSSKEGSSAGGLSRNQTTRQQQQGATPRRREKEKKENEEVIRQLRMICTPGDPNLVYKNFRKIG
QGASGGVYTAIDRQTLPVAIKQMNLEKQPKQDLIINEILVMRESAHPNIVNFKDSYLWQGDLWVVMEYME
GGSLTDVVTAHCMSEAQIASVSREVCEGLRHLHSKGVIHRDIKSDNILLSLNGDVKLKMLEGEPPYLTEN
PVRALYLIATNGTPKIKDWDKLSNVFRDYFKVTLQVDPAKRPTAAAILKHEFFKHTAPLISLAPMIRSSR
KS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pak1 mutant is attenuated in mice (Wang et al., 2002).
References
Wang et al., 2002: Wang P, Nichols CB, Lengeler KB, Cardenas ME, Cox GM, Perfect JR, Heitman J. Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans. Eukaryotic cell. 2002; 1(2); 257-272. [PubMed: 12455960].