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mpk1

Victor ID 4757
Gene Name mpk1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. neoformans
NCBI Protein GI 28974309
Other Database IDs CDD:173750
CDD:143851
Taxonomy ID 40410
Gene Strand (Orientation) ?
Protein Name Mpk1
Protein Length 441
Protein Note Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; cd07857
Protein Sequence 
>gi|28974309|gb|AAO61669.1| Mpk1 [Cryptococcus neoformans var. neoformans]
MDNTPRHLFQTPNNVYILQQPWQFVKELGQGAYGCVSSARNSSTGETCAVKKVTNVFQKKILTKRCLREL
RLLHHFRGHKNITCLYDMDIVFDPPGSGQFREVYLYEELMEADLHAIIRSGQPLSDAHFQSFLYQTLCGL
KYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFQPGAVQTDQGQAGFMTEYVATRWYRAPEIMLSF
ANYTSSIDMWSVGCILAELLGGKPIFKGEDYVDQLNKILNLLGTPTEDTLRRVGSPRAQDYIRSLPIKPR
VKFGTLYPNASPLALDLLSKLLTFDPAKRYGCEEALEHPYLAVWHDPADEPLCEVPFDFSFEEEDSVSGM
RDLILEEVRSFRYLVRQQTMPPVRKDSHELPPAPPAPQHPGAGVGPAFHEKRTAKAIWRNILGLHWRNSW
RGRNYHRIIFVESVTVIGKHR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mpk1 mutant is attenuated in mice (Kraus et al., 2003).
References
Kraus et al., 2003: Kraus PR, Fox DS, Cox GM, Heitman J. The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function. Molecular microbiology. 2003; 48(5); 1377-1387. [PubMed: 12787363].