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GPA1

Victor ID 4754
Gene Name GPA1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii ATCC 42163
NCBI Protein GI 533774
Other Database IDs CDD:128571
CDD:133249
Taxonomy ID 178876
Gene Strand (Orientation) ?
Protein Name G-protein alpha subunit
Protein Length 433
Protein Note anamorph name: Cryptococcus neoformans
Protein Sequence 
>gi|533774|gb|AAA53142.1| G-protein alpha subunit [Cryptococcus neoformans var. grubii]
MGGCMSTPEAPKKTAETKQVPSTSTSSRPPQASTSATATAAGAGTSAANGTANGIKGDTTATNRVGTSGG
QGLAAALASTEPPGAQDSKGNKDRSNQIDRQLEDDQKKFRKECKILLLGSGESGKSTIVKQMKIIHQNGY
SKDELLSFRGVIYKNVLDSAQALIMAMRKIGVDPEDANNRSYADRILEYRMDAGLDAVIPSEILYNIESL
WHDPVIPSVMDRSSEFYLMDSATYFFANIRKIAGPDYVPDEADVLRARTKTTGISETRFNMGQLSIHMFD
VGGQRSERKKWIHCFEAVTSIIFCVALSEYDQVLLEESGQNRMQESLVLFESVINSRWFLRTSVILFLNK
IDLFKQKLPKVPLVQYFPEYTGMRRNINKAAKYILWRFTQTNRARLSVYPHLTQATDTSNIRLVFAAVKE
TILQNALRDSGIL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: gpa1 mutant is attenuated in rabbits (Alspaugh et al., 1997).
References
Alspaugh et al., 1997: Alspaugh JA, Perfect JR, Heitman J. Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. Genes & development. 1997; 11(23); 3206-3217. [PubMed: 9389652].