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VPH1

Victor ID 4748
Gene Name VPH1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99 (ATCC 208821)
NCBI Protein GI 15027611
Other Database IDs ATCC:208821
CDD:144913
Taxonomy ID 178876
Gene Strand (Orientation) ?
Protein Name vacuolar (H+)-ATPase subunit
Protein Length 849
Protein Note V-type ATPase 116kDa subunit family; pfam01496
Protein Sequence 
>gi|15027611|gb|AAK81705.1| vacuolar (H+)-ATPase subunit [Cryptococcus neoformans var. grubii]
MATNYPSLFRSEEMSLVQLYIPSEVAHDTISELAEMSNFQFKDLNPSLTSFQRPFTPRLRRLAEMARRLR
FFRSQITSLSPPLGVPPLAAVPPFTTVGPRAQNAYDELEEKLKEHERRLNEMNKSWEELGRRKSELEENK
CVLKETAGFFDEAGHRHTEIRTSMEDSSDAAPLLEHAAEYGTLPGESGLSGFDLEFVAGTIDRARMPTFE
RILWRVLRGNLYMNYSEIEEPFVDTVSGKETFKDVFIIIAHGQELLAKIRKVAESMGGTLYNIDSATDKR
SDALRQVSARLEDVDNVLYNMGQTRRVELSKIAESLEAWTDAVMREEEIYKTLNLLSYDQGRKTLVAEGW
CPSRDITAIQLGLRRAMDTAGTSVPAILSELRTHQTPPTFHRTNKFTEGFQTLIDSYGIATYQEVNPGLY
AVITFPFLFAVMFGDIGHGILMFLTAAAMIFWERQIAKNGVNENVETFFFGRYLIVLMGIFSVFTGFMYN
DIFSKTLHLWQSGWEWPSNSTGLIEAEPTGNIYPFGMDPMWHGSDNALIFNNSYKMKMSIILGVIHMTFA
ICLQVPNHIHFKKPLNIYAEFIPQMLFFHSIFGYLVVCIIYKWSVDWSQSVTSPPGLLNMLIYMFLSPGT
IEPGTQLYAGQGFIQVVLLLIALVCVPWMLALKPYMLWKEHQRIVAQGYQGLQGQDNGGMHGRDSIGAES
RAEEEEEVGMAVAESSDEEHPFEMGDIIVHQVIHTIEFCLGCISNTASYLRLWALSLAHAQLSEVLWSMT
LQLAFDFNGGLISRAVFLFVMFAVWFGGTVGILCVMEGLSAFLHALRLHWVEANGKHYMAGGYPFTPLSF
ATIGQEEDI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: vph1 mutant is avirulent in a mouse meningo-encephalitis model (Erickson et al., 2001).
References
Erickson et al., 2001: Erickson T, Liu L, Gueyikian A, Zhu X, Gibbons J, Williamson PR. Multiple virulence factors of Cryptococcus neoformans are dependent on VPH1. Molecular microbiology. 2001; 42(4); 1121-1131. [PubMed: 11737651].