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URE1

Victor ID 4747
Gene Name URE1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Nucleotide GI 3688062
NCBI Protein GI 3688063
Protein Accession AAC62257.1
Taxonomy ID 178876
Gene Strand (Orientation) ?
Protein Name urease
Protein Note mating type alpha
DNA Sequence 
>gi|3688062|gb|AF006062.1| Cryptococcus neoformans var. grubii strain H99 urease (URE1) gene, complete cds
CTCNGGCCCATTTGGCNANGGCGTTCCCNCCTAAATTTCTTGCNGACCCNCCAANNTNGGATTTTGGGAC
CGTTTATTTCGGGGTATNTNCCNATATTTCCCATTGCCCATTTTGGCCCAAATTTTGGCCATTAGGTATT
GAGGTTGACTCGNGGCAGAGCAATTGAACATCCGNTGTGCTAAAATGTTTTTTCTAGGTTCATTTGACCA
CAACTTCCNNCCATTTCNTTCTTTTTGTGGATGAGTTTGTCTCTTGATGNACTGTCATATGAGCAGTACT
AACGATCATTTAGTNTGCTTTACTGTCAGAAAAGAATCTTCGTCCTTNTTTGAGGATTTCAACAAGACCA
TCTTGAATGAAACAGGGAAGTAGAGAATGTTTTAGGAGANTTTGGTGGGGATGACTTATGTAAAGAGAGC
TGTTGGAGGGCCCCGTGTTGTTCTTGTAGAGTATGTGTATATCCGGATACCCCGTGTTAAATCTNTTCAG
GAGTCATTTTGCCCAATAAGGGAACNTATCAAAAAGGTCACTGGGTACNTANTAAGCACCGAATTGCCCT
TTTTCCCAANTGGGTTTTCATTCNGCTTATCANTANTAANGCAATTTGGANTGGATAGGCTGGCANCAAA
ATTACTTATTAATTAAATGGTGTTGAAAGTTCNTGAGCANCCAATNTGTTGGGATATACGTCAATTTGAA
ACATTTGTGATATGGCATATTCATCTGCATTCTGGATTATNGATAAGTATGTAACANTCGGCATGTCTAG
ACGAGCAGCAGAAAGNTGANCCCGAGCCAAACGGAAGAAGCGAGGATAATGCCCAAAAAAAAACGTTATA
ACGCCGCCNTCTNTCCTGAAAGAGGCGAAGCAAGATTGCATGTNACGTAAGAATTTATTAGGCGCAAGAG
GATGTAGGAGTTTGAGAAACAGTCGAGGGGTTCAACTTTTGAATTATTGCTATTTCNTTATGGGAAGGCC
ATCAAACACACAGTTGCTTGGATGGGAGGACACGAGCACGGATACACGAGCCCGGATACATGAGCACGGA
TGGAACCGGATGGGAAANTTAAGGTACGTATAGGTGAGTGTCTGCTGATAAGAGACGCGAGGATAACGGG
TGCNTGGGCTGATAGCTGATTGGATTGTCTGGATGGCTNGTATCGTCATTATTAGCCCCACAAAGGCACG
CAGCTCCCACATCCCCTCCGTCCCGTTTTTGATTCCTTGCTCCTCTTTTTTATTTTTTGCTTTCCCTTTC
TTCCTCCTCACCACACCAAGAACATCATGCATCTCCTCCCGAGAGAAACGGCAAGTCCTCCACTCCCAGC
ACCACACTACAAGCTGACTGACTACCACTCAGGACAAACTCATCCTCACCACCTTGGGCACCCTTGCTCA
ACGTCGTCTTGCCCGAGGCCTTATTCTTAACCGTGCTGAGACTATTGCTCTCATCTCCTCGCAGCTGCAG
GAATTCGTTCGAGATGGACGCCACTCTGTCGCAGAGCTCATGGATTTAGGGAAGAAGATGCTGGGCAGGA
GACACGTCAGGAAAGGTGTTCCAGAATCAATTCACACTATTCAGGTGGAAGGCACTTTCCCCGATGGTGT
ATTTTTGGTCACAGTCGATGATCCCATCTCCTCAGATGATGGCGACTGTTAGTCTGAAGCATTCAAAATA
CATCACCAAATGCTAANTATTATGAAAACAGTGAACAATGCCTTTTACGGTTCTTTCTTGCCAATCCCTT
CGGCAGACGTCTTCCCTGCTGCACCCGAGCCAGCCGATACCCTCTTAGGAGCACTTATTTGTCGCAAGGA
GACAGTTAAAATCAATGCTTCCCGACGACGCTTTAGGCTTGAAGTCAAGAATGCTGGAGACAGGCCCGTT
CAAGTTGGCTCCCACTACCATTTCCTCGAAACCAACCCGGCTCTCATCTTCGACAGACTCTTGTCCTATG
GCTACCATTTGGACATCCCCGCTGGTACGGCGGTCAGGTTTGAGCCCGGGGAGAAGAAGACTGTAACAAT
GGTGGAATTCGGCGGAAAGAAGATCTTCCACGGTGGAAGTGGATTGGGAAACGGATCTTTCGACGAGAAT
TTAAGGGAAACTAAAGTTAAGGAGATGGTTGAGAAGGTGGGATTCGGTCATAAGGAACAAGAAAAGATAG
AAGAGGGACCGGTAACTGAAATGAACAGGGAAGTGGTATGTCTCGTGTGACCCATTTGAAATAGTCGGAC
GTCGTTAACTTTTATCGTAGTACGCTTCCATGTTCGGACCAACAACTGGCGATAAGATCAAACTCGCTGA
CATGGATCTGTGGATCGAGGTCGAAAAAGATTACACTGTCTACGGCGATGAATGCAAATTCGGTGGAGGT
GAGTGATCAGTAATCTGTCTTTGGCTTTTGAATTGACATCCGGTATAGGTAAGGTCATTCGAGATGGCGG
AGGTCAAGCATCTGGTAGGCATGATCATGAGGTCCTTGACCTCGTTATTACCAATGCCCTTATCGTTGAC
TGGACTGGCATCTACAAGGTGATTGCAACAGGCCCAACTGTCTGCTCTGTGTCGCTAACGTCTCTTTAGG
CCGATATTGGTGTGAAAAATGGCATTATTGTTGGTATTGGTAAAGCTGGTAACCCCGATATGATGGATGG
AGTCACAGATGGGATGATCGTGGGGTCAAGCACTGAAGTTATCTCTGGCGAAAAGTTGATCACCACAGCG
GGACGTCTCGACGTCCACGTTCATTACATTTCTCCTCAACTCATGACTGAGGTAAGTTTCTCTAGTAGGA
TGGGGATCAGCAATTGATTCAATTGTCAGGCCTTGGCATCCGGTATCACCACGGTTATTGGAGGTGGTAC
AGGTCCTGCAGACGGTTCTAACGCCACCACCTGCACGTCTTCGTCCTTTTACATGCAAAACATGATCAAA
GCAACCGACACTATTCCTCTTAACTTTGGCTTCACCGGGAAGGGCAGCGATTCTGGCACAAATGCTATGA
GGGACATTATCGAGGCCGGAGCGTGTGGATTGAAGGTGCATGAGGATTGGGGCGCGACGGCAGAAGTCAT
TGACAGGGCTCTGAGTATGGCCGACGAGTACGACGTACAGGTGAGTTGCCTATCCGCCTGGCTATGTCTT
GCATAGTGATAATAACTACTCGACTGTAGATCAACCTCCATAGCGATACTCTTAACGAAAGTGGATACGT
CGAGAGTACCTTGGCCGCCATCAAAGGTAGGACCATTCACAGTTACCACACTGAAGGAGCTGGTGGCGGA
CATGCTCCAGACATCATCGTTGTCTGTGAATATGAAAACGTCTTGCCTAGTTCCACTAACCCAACTAGGC
CTTATGCTGTTAACACTCTTGATGAACATCTTGACGTGGGTCCTTTTTCTTCGAGCAATGTTTCAATGCA
ATGCTAATGACAGGTCAGATGCTTATGATCTGTCACGGCCTTGATAAGTCCATCCCGGAGGACATTGCCT
TTGCCGACTCTCGTATCCGTTCTGAAACCGTTGCAGCCGAAGATGTTTTACAGGACACAGGCGCGATCTC
CATGATCTCATCTGACTGTCAAGCTATGGGTCGTATCGGTGAAGTCGTCACTCGTACATGGCGTACGGCT
GCGAAGATGAAGCAATTCCGTGGTCCGCTTGAGGGCGATGAGCCCACGAGAGACAACAACAGGGTGAAGC
GATATGTTGCCAAGTACACTATCAACCCCGCCATCACCCACGGTATGTCGCACCTCATCGGTCAAGTTGC
TGTGGGCTGTTTGGCAGATCTGGTCCTTCTGGACGGAGAGTCCTTTGGTGCTAGACCGGAGATGATCCTC
AAGGGCGGTGTTATTGCTTGGGCTGCGGTGGGCGATGCGAACGCTTCGATCCCCACTGTGCAGCCCGTCC
TTGGCAGGCCCATGTGGGCTCTCAGCCTGAGGCCGCTGCACTCAATTCAATTGTTTGTCAGCCAGGCATC
TCTTGACAAGGGTGGGTCTTCGTTTTTTTTTCTGCTGTCTACAAATGGGTATGGCCTGATGGATTGTTAG
ACCTCGTTAAGAGATATCGGTTAAGGAAGAGGGCAGAGGCTGTCAAGAACTGCCGTTCGATTGGAAAGAA
GGATATGAAGTGGAACGACACTATGCCAAAGATGACTGGTGAGTGACAGTAACCACTGTGTGAACGAGTC
ACTTACTCAAGCTCCATTTAGTCGATCCGGAGACCTACGACGTGCGGGCCGACGGAGTCCTTTGCGACGT
CCCACCCGCGGACAAACTCCCATTGACCAGGAGATACTTCGTTTACTAAGTATCAGTGCATTTCTCCATT
ATTCATGAACAACTGTATATATATTTAATAAATCTCTAATAAACCTCTAGTTATCTTCCAATGGAGTCTC
AAGGATAAGTTATGAAATTGTACAAATGGTCAACGGAGATGAATCGATGAATTTTGNNCCTTGGCTAGGA
TCTGATAGGTCAAAAGNCTTCACAATNACTCGTGACATTGCCAATTTTGTTGCAGATCATAAGTGAGTAC
TTCGGAATAAATTTGGACTGCCATTTTTTGTCCTGCAACCGACAGTTCAAACAGGAACCCCTAAAGGCCT
TTTTTCAGGTATCAGATTGAATGACTTGAGTCAACCCAGAATCTAAAACCAAAACATAGAATCCGTCATG
ACAGGTGGTGAGGGCAGACGGCCTGCCGTTGAATTTTAAAGCATCATACCTTTAACCTAACTATCGATAC
ATGCTTTTACTCCCAAAACCGATTGGTCCAGATGCTGAACTCGTAATGTAGATGGAAACATGATATTGAA
TAAAGTGGTTTTCCAAAAATGCGCTATGCCCTAGTCGTTTGTTCCAAATGTAAACCGGCAATATGATAAT
TCTCACCCAATAATCTGATACACAACTTCGAGGTCAGCTTTCGGAACAGTTAAGTGACAGCATGGAGAGA
AATATCCTACGTTTTGCAGATGACAACTATTCTGTCCAGTCGAGAGATAAGTGAGAAGGTAGTAGTTATG
CCAAGAGCGTAACGCATGTAATTCTCAGATTCCAGAACTGGGGACCATTACCATTCAGCTCAAACGCTCT
TGTCGAC
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ure1 mutant is attenuated in mice (Cox et al., 2000).
References
Cox et al., 2000: Cox GM, Mukherjee J, Cole GT, Casadevall A, Perfect JR. Urease as a virulence factor in experimental cryptococcosis. Infection and immunity. 2000; 68(2); 443-448. [PubMed: 10639402].