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sec6

Victor ID 4742
Gene Name sec6
Sequence Strain (Species/Organism) Cryptococcus neoformans var. neoformans JEC 21
NCBI Gene ID 3254663
NCBI Protein GI 58260630
Locus Tag CNK02540
Genbank Accession AE017351
Protein Accession XP_567725
Taxonomy ID 214684
Chromosome No 11
Gene Starting Position 737133
Gene Ending Position 739846
Gene Strand (Orientation) +
Protein pI 5.38
Protein Weight 81621.55
Protein Length 770
Protein Note Supported by
DNA Sequence 
>gi|58271748:737133-739846 Cryptococcus neoformans var. neoformans JEC21 chromosome 11, complete sequence
AGTGATATCCTATTCCCAGTACATATTCTGCTCCCCATCTATACAGTCAGGTAGTGGAGCTGGCAAGAGC
CAGATCCAACATATCACCAGGCGGACAACAGGTCCAGCTCGATAGCAACCGCGAATCTGCTCGCCCACAA
TGTCATCAGCAAACCCATCGTCACTCATTGCAGAAGTCCTTCGACAACCCGACGATCTTCTCAAGCTCGC
CGCATATCGCAAGAAGCTGTTGAAAGAAAAATCGGCCCTGGATACCAAGCTTTCGGAGGGTGTGAAATCT
CAACTAGACGCAACGAGGGATGCGTTGCTCAAATTACAAAATAGTAGAGCTGCGGTGACACTGATAAGAG
AGGAGATGTTGGCCGTGGAGAAGCTTATGGGTGAGGAAGCTGGTGGGGAGGCATTTGATAAGATTACGAG
GGTAGGCATAGTATCATCTTAATGCCTTGAACGAGCTGACAAGAAGCCAGGTTTCGACGGTACACCGTAA
CTTTGCACAAACGTCCAAGATGGTACAGAACCTGCGATCAATGTCCGAGAAAGTTGATTACTTGTCTTCT
CTACTTGATTCTGACAAGAATCATCCCGATGGGGCTGCGGGTCCTTCTCCCAATCTCTTGCCCATTCACT
TTCAATTACAACAATTGGAAGCATTCCGTAATGAGACTTTGCATGAGGCCAAAAAGTCAAACCCTCAAGA
TAGAGAGACACTGGTGAAGTGGTTTGAGAAGGTCGATAAAGTGGCTGCGGACTTTGAAGCATGGTTATGG
GAGATAGCAGGAAGTGTGGTTGAGTTGTTGAGGAAAGGGAATGGTGGGACTGTGGTTAGACTTTTGAAGA
TTATTGAGGTCGAGGGTAAAGAAGACGAAAAGGTTCGACATATTTCAGGCTCAATGCGATAGCGGTGCAA
GCTAACATTATCATAGGCTGTAGCAATGCGTCTCGTACGCAAAGTCACGACTACCGATGCTGCTTCAAAA
TTTAAATCTATGCAAGCCAACGCTCGAGTCATCAAGAATTATCGCCACAAATTCCTCGATGTCATGAAGT
CCACCGTGCAGCGATCTTTTGAAGAATACTTTCTTGATAATCAGCATGACTTTTTAGGGTTCATCGAAGG
GCTCGGGTGGGTGTACAAGGACATCATTAGGATCAAAGACGACATTGAACCTCTCTTCCCTGCCGACTAC
GAGATTACAGCTTTCCTTGTCAAAGCCTACCACAAGTCTCTCAATGAAACGCTGATCAAGGTGGTCAAGT
CTGCACCCGAGGCCAAGGTCCTCTTGGAGCTTCATGCATGGATCAAAGAATACAGGGTAAGCATGAAAGA
GCTTGAAATCCCTCCTGCTTGGATCCAACCTCCATTGCTCGACGGCAAGTCTCAAGACCTTATCGAGGAC
TATGTCAAGCTCATTGTCACCAAACTCGATGAATGGACTGTTAACCTTATGCGGGAAGAGACGGGCAAGT
TTTCATGGCGTACTCGCGAGCCAGAGCAGTCAGACGATGGTCTGTTCGGTATGGAGGGTGTGGTCGATTT
CTTCCAGTTGGTCAACCAACAGTGCAACCTAGCACTGGATTCCAACCAAGGTGCAGTGTTGGCGCGAGTG
GTGACAGAATCAGCAAAGGTGATGAGGCGTGTTCAGGACCAATGGCTCAAGCTGCTAGCAGACGAGATGA
AGGCGCAAACAGAAAAGAAGCCGGAAGAGGTATTGCCAGGATTGGTCGAATATGTCATTGCCCTTGCTAA
TGACCAACTCAAATCCGCCGACTATGCCGAAGCTCTATCTGCCCGCTTGGAACCCTTGGTATCCGACAAG
TACAAGGAAATTATCTCAGCTCGACTTAACGAGGCGATCGATGGCTACATTGACGTTGCCAAGCGCTGTT
TGTCTTGCCTTGTTCAGTTTGTGTTCCATGACGTACGAGTCGCCACTAAAGCGCTCATCACCCCCGCATG
GTACACTGAACAGCTCATGGGTCAGATTATGGAGACGATGAAAGACTATATGAGTGATTACCAAGCACAC
CTCCATCCGTCCGTTTTCGAAATCCTCGTTGACAATCTTCTCGACGCCTTCCTCATATCTTACCTCTCCG
CCCTTCGACGAGCCTCAACCAACTCCCTTCGTATGCCCATCGCCATTCAAAAGATCAAATCCGACATATC
ATCCGCGTTCCAGTTCTTCTCCCAGTACAAACCCTCGCCGGGTCTCGAAGAAAACTTTGAAGTGTTAAAC
ATGATTGTGAACATGCTCGCGGCATCTCCCGAAATGGTTTTCATGGACTACTGGAATTTCGCCAAGATAC
ATGGTCCTCAATTACAATTTGCGGAAGCTTTGATGAAAGCGAGGGATGATTTAGATAGAGATGGTGTCAA
GGAAATTATGGAGACATTAAGAAGGAAAGCCAAGGAGGAGGATATTGGAGAGCCAGAGGAACCTACAATT
ATGGTAAGTCATGGCGCACTTGCTCGTCCGAAGCTTCACTCATGTCATGAATAGGTCAAAGTTCAAGCAA
CTTCTGGAGGATTGTTGTCAAACCTCACGAATCTTGCTGGAACATATGCTAGCAACTTCGCTGCAGCCGG
TCTCCGGCCGTCATAGGCTTACTCGTGCTTGTTATTCAGGGGGGACATGCCTTTTTCACCTGCCATGCTT
TCACAACTTTACGCTTCATGTTACACTGCGTTGTACTATACTCATAACCACATG
Protein Sequence 
>gi|58260630|ref|XP_567725.1| vesicle fusion-related protein [Cryptococcus neoformans var. neoformans JEC21]
MSSANPSSLIAEVLRQPDDLLKLAAYRKKLLKEKSALDTKLSEGVKSQLDATRDALLKLQNSRAAVTLIR
EEMLAVEKLMGEEAGGEAFDKITRVSTVHRNFAQTSKMVQNLRSMSEKVDYLSSLLDSDKNHPDGAAGPS
PNLLPIHFQLQQLEAFRNETLHEAKKSNPQDRETLVKWFEKVDKVAADFEAWLWEIAGSVVELLRKGNGG
TVVRLLKIIEVEGKEDEKAVAMRLVRKVTTTDAASKFKSMQANARVIKNYRHKFLDVMKSTVQRSFEEYF
LDNQHDFLGFIEGLGWVYKDIIRIKDDIEPLFPADYEITAFLVKAYHKSLNETLIKVVKSAPEAKVLLEL
HAWIKEYRVSMKELEIPPAWIQPPLLDGKSQDLIEDYVKLIVTKLDEWTVNLMREETGKFSWRTREPEQS
DDGLFGMEGVVDFFQLVNQQCNLALDSNQGAVLARVVTESAKVMRRVQDQWLKLLADEMKAQTEKKPEEV
LPGLVEYVIALANDQLKSADYAEALSARLEPLVSDKYKEIISARLNEAIDGYIDVAKRCLSCLVQFVFHD
VRVATKALITPAWYTEQLMGQIMETMKDYMSDYQAHLHPSVFEILVDNLLDAFLISYLSALRRASTNSLR
MPIAIQKIKSDISSAFQFFSQYKPSPGLEENFEVLNMIVNMLAASPEMVFMDYWNFAKIHGPQLQFAEAL
MKARDDLDRDGVKEIMETLRRKAKEEDIGEPEEPTIMVKVQATSGGLLSNLTNLAGTYASNFAAAGLRPS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sec6 RNAi mutant strains of C. neoformans were defective in a number of virulence factors and demonstrated attenuated virulence in mice (Panepinto et al., 2009).
References
Panepinto et al., 2009: Panepinto J, Komperda K, Frases S, Park YD, Djordjevic JT, Casadevall A, Williamson PR. Sec6-dependent sorting of fungal extracellular exosomes and laccase of Cryptococcus neoformans. Molecular microbiology. 2009; 71(5); 1165-1176. [PubMed: 19210702].