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PLB1

Victor ID 4740
Gene Name PLB1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Nucleotide GI 7637534
NCBI Protein GI 7637535
Protein Accession AAF65220.1
Taxonomy ID 178876
Gene Strand (Orientation) ?
Protein Name secreted phospholipase B
Protein Note cryptococcal virulence factor; Plb1
DNA Sequence 
>gi|7637534|gb|AF223383.1| Cryptococcus neoformans var. grubii strain H99 secreted phospholipase B (PLB1) gene, complete cds
GAGCTCGGGCAAAGGAGGTAAGAACAGCAGCTACGTTTTACTCCGATGCAGAAGAAAAATGTTATAGGTT
ATACGTTTTATATCGTTATGACTGGCGGGGGCCGTTTACTCTTCTACGGCGGCGACGACATCGTTTATTT
CGAAGATCCGAAACTGCTTTTCACCCATTCGTCANCTGTCGAAGCCTTTTTCTTTTCCCTTTCCATCGCT
ATATCTTGCATAAAGTGCTTGGTGGGAACCATCTTAACATTATCTCGACCTATACACCTTTAACATCCAT
ANCCGGTCACTGNTANGTACATTATTGGCTTTTCCGGTTTTCGGACTGAAATCCCTTTCAACACACTTAC
ATTAAACATTCGGTAGCTTCAATAATGTCAATCGCCACGGGTACTTTTGCATTCTCACTTTTTGCCACCA
TTGCTTTCGCTGTTCCTCCCGAGACTCCGCGGATTGAGCTTCAGGCGGAGAGAGGTTTGGGTGATAAATC
CTATGCTCCCTGGCAAGTCGATTGCCCCTCCAATGTTACTTGGATTAGAAATGCCACTGTAAGTTGCAAT
ATCCTCGTCACCAAAATGTGGAACATTACTTATGATCATTCCCGGCTAGACTGGTTTAGGTTCCGGTGAA
CGAGCCTACATTGAGGCTCGTGAGAAACTTGTCCAACCTGTAATCGAGCAAATGATGGCTGCCCGAGGGC
TCGAAACTCCTCCCCGGACACCTAACATCGGTGTCGCCTTGTCCGGCGGTGGTTACCGTGCAATGCTGTG
AGTGGATTAATGTTGCAAAAGATATGCTCATTACTTATCATTGGCACAGTACGGGGTTGGGTGGTATCAT
GGGCATGATGAATGAGAGCACGGAAGCGTCCGAAAGCGAGACTGGTGGTTGGCTTGACGGCGTAAGCTAC
TGGGCTGGTCTGAGCGGTGGGAGTTGGGCAACCGGGACTTTCATGTCTAATGGGGGTCAGTTGCCCACAA
ATCTTCTTGAAAACGTGGGTTTCTGGCATGATGTATGTGTTCATCTACTGACTTGCGTGATAGCTCTGGA
ACATCGATTCCAATCTCGTCTTTCCTGATGACGACAAGCTTTCATTCTACACTGAACTTTACACTGAAAC
CAACGCCAAATCAGATCTCGGTTTCCCCATTCAAATTACTGATGTTTGGGGTCTTGCCATTGGCTCTCAT
GTTTTACCCGAGCGTTACCAGCTCTCCAACACTCCTAATCTCACTTTTTCTAGCCTTCCCTCTGTCGTCT
CTGCCTTAGGAAACGCAAGCTTGCCCATGCCCATCATTATTGCAGCTGAGTAAGTCAATATGCGACCGAT
GATTTTCATTTGCTGACAGCCGGAAAAGGCGAGAGGCAGGAGAGCTTGTCATTGCTGAAAACGCAACTGT
CTGGGAGTTTACTCCATACGAATTTGGTTCCTGGGCTTTTGGTAGCCAATACAAAAGCCCTGGTGCCTTC
ACCCCTATTGAATATCTCGGTACTTCAGTTGACGATGGTTCACCTAATGGCACCTGTTGGAAGGGCTTTG
ACCAATTGTCGTGAGTTGGTTCATAGTGTACTCGAGAGAAAGATTCCAGCTCATGTTATCTTCCAGCTTT
GTCATGGGAACTTCTGCGACTCTTTTCAATGGTGCCTTTCTCGAGCTTAACGGCACAGACAGCGGTCTTC
TTACCAACTTAATCACTGCCTTCCTTGCCGATCTGGGAGAAGACCAAGCCGATATTTCCCGTATCCCCAA
TACTTTCTCTAATTACAACTCGGGGGAGAACCCCATCTACAACCTCACTTACATCACCCTCGTCGATGCC
GGAGAAACCAACCAGAACATTCCCCTCGAACCGTTGCTCGTTCCCACCCGTGACGTTGACGCAATTGTGG
CATTTGACTCATCCTACGACACCGACTATATCTGGCCAAACGGCACTGCTTTGAGGACTACCTATGAGCG
AGCCAAGGTTTTAGCTGAGCACGAGAACACAAGGGTGTTAATGCCCGAGGTCCCTAGCATGAACGGCTTC
GTCAATGGTGGTTACAACTCAAGGCCTACTTTCTTTGGCTGTAACGATACCACCACTCCTTTGATCATCT
ACGTACCATCTTACCCATGGAGCTTTGCTGCCAATACGTCTACTGTAAGCTCTTCATACCACANGGCCAA
AATTTCCACTGATGATCGAAACAGTACCAACTTTCGTACGAGAATGATGAAGCCAACGAAATGTTGCTCA
ATGGTATGCGCTCTCTCACTCTCAACCACTCTGTTCCCACCTGGCCCACTTGTTTTGCTTGTGCCCTTAC
CGACCGTTCCTTCATGTACACGTCCGAGAACCGATCCACCACCTGTCAAAAGTGCTTTGACACTTGGTGT
TGGGCTGGTGACGACAACACCACCGAGCCTGCGACATATGAGCCTGTGATCAACAGTGTTCCCCCCTGGT
TAGTCGCCAACAACCTGAGCATCGGCGTCGCCGATGCTCCTGCGAGCAACGAATCCACTGCTGGTACAGC
GTCCAGTGGTGCAGCGAACGCGGATGTGAGTATGGGTATGGTCGCGCTCGCTGCTGGCTTGGGCTTGATG
CTTTAAATGGATCGAAGTTATCCTGTAATCCTCGCGAGAGCATTATTTAAAATTTCCCTCTGCCTCATTT
TCCGTATCTACTTCACAAGTAAACAATCTANAAATCGGATCTTCATTTTANAACACTACTTCATTGTCTC
ATAAAAGCTCTGGCTACTGCATGCGCCACAGCACTGAATCACGCATAGACGTATAATAATCATCTGATGT
ATAACCTGTTTCACACATCATACATGATGAGAAATGGGACAAATGCTCAGAAAATAACTTGAACATAACT
GAACAACATCGACAATATCCTCGCTACGCCGGGCACACAACGTTACAACATTTGCATAAAAGAGTGGCAC
TCAAAACCAAGGCGGTCGAGCGTTAAATTCTCGCCTTCTTCNTAGCCGCCGGTTGAGCAATATTGCCACT
TGCGGGCCTGAAATTGCTACTTGATGGCAGCCTGCCTCCAGCCATCGATTGAGGTAGACTATGAAATCAT
GCATCAGTGTCCGGAATAAATCATGACACAAAGACATAAAAAGGCCATACGATCCCATCTTAGCATCACC
GTTATCCTCATGCGTCACCCTTCTTGTGGGATATGAGATCGAGCTGCCTTCGAACACACTTCTAAATTGA
CGAGTTCAGCATCGGACATGCGTTCAGTTCATAGCTCCATCGCCTTACTTGGTATCGACTCCCCCTTCTT
CCTGGAACCAAGGATGCCTCAATGCATCCCTTGCCGTTATCCTACGAGCTGGGTCCCATTCGAACATCTT
GATGAGAATATCGTATCCTTCAGGCGAGTTTGAGCGGGCATGATACCATGGTGCAGGAGGATTGGAGTGG
GGATAAGGACCAGTGGCTTGGTAAGTGCGGTATTCAGGCATGTGGACTATACCTGGCCATTGTTCGGCTA
AATAGTATCAACTATATTAGCTTTGAAAATGAGGATAGACACAAGATGTGGACGACGTACGCTTGACAGG
ACCAAGAACTTCACAGATTTTGCCCATCTGGTCGCGCTGGAATGGCAAAGACTTCTTGCCGTCCATTCTA
GCCTCGTCGCCTTTGAAGATAGGGCGAAGAGAGAGCAGCTCCGCATAGATACAACCTACCGCCCATATAT
CTAATCCAATCCAGTAAAAAGAAAACCCGAAAAAATGAGAGGTCATTCAAACATTGTGAATGCAGCTGAA
TTTGAACCCACCGACAGCGGCAGTGTAGTGCTTGGCTCCCAATATTAACTCTGGCGCTCTGTACCCAGAT
AGTCACCACGACCTTAGAGACCTTGNTGCGATAATGGTTTATGCCACAATCGTGCCAGCCCGAGATCACN
TATCTTAACAACTCCTTGGCTGGTAACCAAAATGTTAGCCGGTTTGAGATCACGGTGGAGGACAAAATTA
GAGTGAAGAAAGTGCACTCCGCAGAGAAGCTGGTGAAGAAGGCGGCGAAGTGTGGAAGGTGGGATAGAAG
CTCGTGCAGTTTGAGAATGGTAGTGAATAATTTGCTAGGCATTATGAGTGAAGGCACGACTTGAAAGGTG
AAGTGTGATGACGCACTAGAAAATCATGTTCCGCATACTCAAAAACCATATAAATAGACTTGTCTTCTAA
TATGACTTCACGCAGCGATACCAGATTGCGATGGTGGAGTTCACGGTTGAGCTGAAGAAGTAAGCGGCAG
AAGGTGATCGCTTGAATCGACACACCATAATTTCTCTCGCTCCACTTTGACTGATACCGGCGTAGGTCAG
TACATCGCCTTCCTTATCAGGCTTGAACTTCTTTATCGCGAAGACGTCGCCCTTTTTGGCGGGACGGTCG
CCTGGGCGCATACACATTTCGGGATTATTGAGAGGGTCGCTGTCTATCGGTGAAGCTAGGCGATGGTAAC
TTGTCTTTAGGTAATGNTAAGGNTGCTNGAGTCGAGCTGGGCAAGGNGCTTTTGGCAGAGGCTGTTTTGG
GTGGTGGGAGGAGCACTGCTTTGTAGACTCTTCCATAAGTTCCTACACATATATAAGTAATCGGTTATCC
CACGTAGGAAATATGACTTACCGGAAGATATGAATCCCAGAATCTTATATGTCTTCAAGACGCTGAGACA
GCAGTTAACCGAGCATATTGGAGCTC
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: plb1 mutant is attenuated in murine macrophages and in mouse respiratory infections (Noverr et al., 2003).
References
Noverr et al., 2003: Noverr MC, Cox GM, Perfect JR, Huffnagle GB. Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production. Infection and immunity. 2003; 71(3); 1538-1547. [PubMed: 12595473].