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gcs1

Victor ID 4732
Gene Name gcs1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. neoformans JEC 21
NCBI Gene ID 3259176
NCBI Protein GI 58270488
Locus Tag CNH02280
Genbank Accession AE017348
Protein Accession XP_572400
Taxonomy ID 214684
Chromosome No 8
Gene Starting Position 491593
Gene Ending Position 493560
Gene Strand (Orientation) +
Protein pI 8.05
Protein Weight 46322.97
Protein Length 450
Protein Note Supported by
DNA Sequence 
>gi|58272473:491593-493560 Cryptococcus neoformans var. neoformans JEC21 chromosome 8, complete sequence
CCGCTTCCGACGGATTATTTGTTTTCGCCAAATAGGAAATCACTTGCCAAAACTACCGTAAGCACATCTG
CCCATTGTTCCGCAATACTCATTCCCTTCATAAATTCACCATCTATAGGCGGCGTAAACCTAAAGGGTGC
GCCAGTAGGCAATAATGAGTGATTGTGGGTATATCAGGATACTGAATGAAAACATCCCACTTACGTCGCT
CATAGCCGGCACATTGTCCTTGCTTGCGGGCATCGTCTTTTTAGTGTTATGGACGGTTGTATGGTCTATA
TGTCTGCTTGGCTGGCGAACCGCGTAAGTTTCTGTTGCGGAATTGTACTCGTCTAATTTATCATTCAGGC
GCATACGGTACGCTCACCCAAATATTCCCTCACGTCTTTCCAAGCTGCCAGTATCGTCTGCTCCTGGTGT
CACCATCATACGGCCTCTGTGTGGACTCGATCAGAATTTATACAACACTCTTGAAAGCGTGATGAAACTC
GAGTATCCCAAGTTCGAAGTGATATTTGCCGTTCAAAACGAAAAAGATGAGGCGCTTCCAGTCGTAAATA
TGGTCATGGAGAAATATCCAGAGGTGGAAGCCAAAGTAATCATAGGTGAATATTCTCTTGATCACTCGAT
GAGTATTCTAACCATATCATAGATTCACGCAAGGTTGGGGTGAATCCCAAAGTCAACAACCTGATGACTC
CCTTCCAAGAAGCCAAATATGATATGTTATGGATTCTTGACTCGACATGTTCTGTCCTCCCCGGTACCCT
CGGTCGCTCTGTCGAAGCCTTCTTCTCCAATACAAGCAGTACCGCATCACCTTACGACCCAGAATCATCT
CCTCTTCTGTCGATCTCGGACGATGTAAGGAAGCCGCCGGTAGCTGGGGAAGTGGGTCTAGTACATCAAG
TGCCCATAGCGGTTTGCTATCAGAAGACATGGGGAAGCCTGATTGAACAAGCTTACCTTAACACCACGCA
CGCGAAAATGTACCTTGCTATCGTGAGTGACTGAATATCTCCCATGTCTGAGCTCGATCTGACTTTTGTG
TATTAGAACGCAACATCCATCGACTCTTGCGTCGTCGGGAAATCCTGCATGTATTCACGCGATAACATCT
CTCACCTAACGACTCCCTCACCATCTCTGCGCTCTCTCCCCGATCCACCGAGCGGACTCGCCGGATTCGG
TCCTTTCCTCGCAGAGGACAACATGATCGGTCTCTCCCTTTGGCACGAGCTCAAACTCAAACATTCAATG
ACTTCGGATGTTGTCCTGGACTTTATCGGGTCGCTCTCTGTGAGAGAATATGTCAACCGTCGGATCCGCT
GGATCCGAGTCCGAAAGAAGATGACCTTGGCGGCCACTTTACTTGAACCATTGACGGAGTCAATCATCTC
TGGACTATATGGTGCTTGGGCAATCTCTCGGTTATTGGGAGGCAATATCCTTCCTTTATTCTTACTACAC
ATGGCAGCTTGGATCTCTGTGGATCTCTCAACCAAACGGGCGCTTGAGACGAACATCAAGGGCATAGGAC
CTCCAGAAAACAAGGTCACGTTCTTGATGGCTTGGGCAGCAAGAGAGTGTCTCGCATTGCCTATATGGAT
TTTGGCGATGACAAGCTCTGAAGTCGTATGGAGAGGGCAAAAGTATAAAATTATTGATTCCGGTGAGTTG
ATCGATATAACATGACATGCTACATCCTTTGCTGATGATGTTTATAGGAGAAGCAATTCGTTTGGATGAC
CGAAATTGATTACGACATTGCATTGATATGAATTTTGGTTTTCAAAAGCTCTGCATGTTTACTGCATATG
TGTGGATGTCCTTCGTCGTTTAACAGAAATTCTTGTTCCTCAACAGATGTAAACGCATCCTGAGAGCTGA
GCCAGCACTCTCTGGTTCGATAAATAATTAACTTTTGACTACTTTAAATGGTAACGCATTGTTGATTTAC
AGAATGGC
Protein Sequence 
>gi|58270488|ref|XP_572400.1| hypothetical protein [Cryptococcus neoformans var. neoformans JEC21]
MSDSGTLSLLAGIVFLVLWTVVWSICLLGWRTARIRYAHPNIPSRLSKLPVSSAPGVTIIRPLCGLDQNL
YNTLESVMKLEYPKFEVIFAVQNEKDEALPVVNMVMEKYPEVEAKVIIDSRKVGVNPKVNNLMTPFQEAK
YDMLWILDSTCSVLPGTLGRSVEAFFSNTSSTASPYDPESSPLLSISDDVRKPPVAGEVGLVHQVPIAVC
YQKTWGSLIEQAYLNTTHAKMYLAINATSIDSCVVGKSCMYSRDNISHLTTPSPSLRSLPDPPSGLAGFG
PFLAEDNMIGLSLWHELKLKHSMTSDVVLDFIGSLSVREYVNRRIRWIRVRKKMTLAATLLEPLTESIIS
GLYGAWAISRLLGGNILPLFLLHMAAWISVDLSTKRALETNIKGIGPPENKVTFLMAWAARECLALPIWI
LAMTSSEVVWRGQKYKIIDSGEAIRLDDRN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: gcs1 mutant is attenuated in mice (Kechichian et al., 2007).
References
Kechichian et al., 2007: Kechichian TB, Shea J, Del Poeta M. Depletion of alveolar macrophages decreases the dissemination of a glucosylceramide-deficient mutant of Cryptococcus neoformans in immunodeficient mice. Infection and immunity. 2007; 75(10); 4792-4798. [PubMed: 17664261].