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gcn5

Victor ID 4731
Gene Name gcn5
Sequence Strain (Species/Organism) Cryptococcus neoformans var. neoformans JEC 21
NCBI Gene ID 3253516
NCBI Protein GI 58258473
Locus Tag CNA03280
Genbank Accession AE017341
Protein Accession XP_566649
Taxonomy ID 214684
Chromosome No 1
Gene Starting Position 855965
Gene Ending Position 858794
Gene Strand (Orientation) +
Protein pI 5.91
Protein Weight 86292.3
Protein Length 812
Protein Note Supported by
DNA Sequence 
>gi|58271746:855965-858794 Cryptococcus neoformans var. neoformans JEC21 chromosome 1, complete sequence
GCCGGAACAAAACGGTTATTCTTCTTCATTGTATCCAGCTAGCCATAAATCTTTCGGTTTCCGCTATGGC
GCCAAAACAGCGTCGTGCAACCAACTCCAAAGCCAAAGCGACACCGACATCTGTCACCTCTCCGCCCGAT
CAATCATCACCAGTACGCTCAAGAGGCGGGTCATCATCCCTCTCCCCGATCAGGTCACCGCAAGAAAACT
CCGACTTGGAGGACAACAACGAGCGGCATCCAGGGACCAACGGATCTGGATTGAAGGCCGAAGACGAAGG
GTCGACAGATTTACTTGATAGAGATGGCGATTTGGAAGAAGTTCATGCCTGCCCGGACAGTATTACATTT
CGTTATCCTTCGTCGGTTCCCGATTTTACCATCCTCAGTCCACGTGAAAAAGCTTTCAAAGTAGCGAGGT
TCTTACATTGTACAGCCCCTAGTTGTGCCTGCACTGGCCTTGAACCTCCTGCCGGCAGAACGATCCGAAT
AACCAAACATGATTCCAGCAATGAGGACGAAGACGATGAGGACGAGGATGACGATGTATCTATGGAGGAC
TCTGAAAATCCATTGGATTTTGAAGATAAGAAAGATGAATGGAGGACGAAAGAAGGGTGGTGGAGAATAT
GCGGAAAGTGTGGACACGGTTGGGAGAGTGGGGGGCATGTCTGGGCTGATGATGTCCCTCCGAAAGAAAG
GACAAGAAGAGGCAAGGTTGTTGGGAGGATAGAGGAAATACTCGAAGTAGGACTGCACCGTTATCATCCG
AGAAGTTGACTGATCAGCCTCTAGGATGAAAACAAGCTCGTTGAATTCCCCACTCCTCAACCCGAATCCA
TTTCTTCCCTGTTGAAACAATTGCACGAATTTGTACCCCCGCCTGCCGGGAAAACGACCATTTCTGCTCT
TCCTCCTCCTGTTGATCTTTCTACCCCTGATGATGATACGCAAGAAGATAATAGTGACGGCGAACGACCG
CGAAAGCGCCGACGGCAAGCAAGCGAATCTACTCACTCTGATATCGAAGGAGAACAGCACCGAGGTCAGG
GGAAAAAGAAACAAGGAAAGGGCCCTGCGAAAGGCGCTAAACCGAGGGTACCCCGTACTGTCGTCCGAGG
GGCGCATGGTTTTATTCCTATGGCGACGGACCCCGACGGCAATCAGCATGTTGAAGGACACCTCCCCATT
AGTGCCGGAGGTACAGGGGCTGATGAAACCTTTGAAGAGGAGGAGGAGGAAGAGGAGGAGCTGTCAACAG
CTAAACGGCCAGAGCTGGATGAGACCGAGAGAAGAAGGAGAACAGAGATTAAAGTCAAGGAAAAAGAAAG
GGAAGAAGAGCTAGTCAGCAGGTTGGCTGCTGGTGTCAATCCGGAGGATGCAGGAGGGGCAGTCGAAATT
TGGGAAGGGATTGAGCTGGTAAACGAACCACATACCGCTCCGAGAAGGATTAATACTGATGAATAAACAG
CAAAAGCTTCCTCTTCGGCCGGCCGCGATTGAACAAGCAAATCGAGAAATCATGCTACCCGTCGTGTCCT
CCCGCAACCCAACCCCGGTCGCCACCATTCTACTGGTTGGCCTCAAGAATGTCTTCCAACGTCAACTTCC
AAAGATGCCTAGAGAATACATTACCCGCCTAGTATTGGACAAAAATCATATCAGTATGGCGATCGTTAAA
CGAGGGTACCGGGTAGTAGGTGGAATCTGCTACAGGCCCTTTGAGGCTCGAGGGTTTGCGGAGATTGTTT
TTTGTGCCGTAGACAGTTCCGAACAAATCAAGGTCAGTCAGTGTTCAGCCACTTTCATCATTGTCGGGCT
GATGTCTTAATAGGGTTACGGGTCACATCTGATGAATTCGCTCAAAGACCACGTCCGAAAAGCACACCCA
ACTATCAATGTCTTCCTGACTTATGCAGATAATTATGCTGTGGGATATTTTAAGAAGCAGGGTTTCACCA
AAGAAATTAGCTATCCGCGTGAGCGCTGGGTCGGTTACATCAAAGATTACGAAGGTGGGACCATCATGCA
GGGGCGAATGCTGCCAAAAGTCAAGTATATGGAGGTCCATCAAATGTTAGCGGACCAAAAGGCTGTGAGC
TACGCATCCTATGACAAATGCTCCTTGTTAATCTAATTCCTGTAGGCCATAATCGCTAAGATCAAAACCT
TGACCAAATCCCATATCATTCACCCGGGTTTACAAATTTTCAAGGAACGTCAACCTGATGAAGAAATCAA
ACTCACGAAGGAGCAAGTTCCTGGATTAGGTAAGTTATATTTGTATATATCATTGTGTACACACCAACGG
GCTGACACCGCCATAGCTGAAAGTGGATGGAATCCCGATCTTGATGATATGTTCGCGCGCCTTCCGTTCT
ACGCCTGTCTGAGGTGAAAGCTAATAAAGAGTGGATCGGTATTAGCGTTCGCCAACCAAAGCGAAATCCA
TACCATGTTCTCCTTCAACATGTTCTGAATGATCTGCAGAATGAGCCTTCTGCATGGCCTTTTGTGAAGC
CTGTGGACTCAAGTGTAGTGGCGGACTACTATGATGTAATCAAGGACCCTATGGGTGCGTGTAATATTTT
TTGTTTCCCGCCTCGTTATGAAACGCCTGACCCCATTCATGCAGACCTGTCCACCATGGAATACAAATTA
GAGAACAACCATTACGAGTCTATTGAAGGCTTCGTTGCCGACGTGAAGCTCATGTGTGCAAATTGCCGAC
AGTATAATGGCGAAAAGAGCACCTACACCAAACAAGCAAACTTGTTGGAAAAAGCTCTAGATAGAATCTT
GAAAAAACGGAAATCAGTTCTGGCTGACTG
Protein Sequence 
>gi|58258473|ref|XP_566649.1| transcriptional activator gcn5 [Cryptococcus neoformans var. neoformans JEC21]
MAPKQRRATNSKAKATPTSVTSPPDQSSPVRSRGGSSSLSPIRSPQENSDLEDNNERHPGTNGSGLKAED
EGSTDLLDRDGDLEEVHACPDSITFRYPSSVPDFTILSPREKAFKVARFLHCTAPSCACTGLEPPAGRTI
RITKHDSSNEDEDDEDEDDDVSMEDSENPLDFEDKKDEWRTKEGWWRICGKCGHGWESGGHVWADDVPPK
ERTRRGKVVGRIEEILEDENKLVEFPTPQPESISSLLKQLHEFVPPPAGKTTISALPPPVDLSTPDDDTQ
EDNSDGERPRKRRRQASESTHSDIEGEQHRGQGKKKQGKGPAKGAKPRVPRTVVRGAHGFIPMATDPDGN
QHVEGHLPISAGGTGADETFEEEEEEEEELSTAKRPELDETERRRRTEIKVKEKEREEELVSRLAAGVNP
EDAGGAVEIWEGIELQKLPLRPAAIEQANREIMLPVVSSRNPTPVATILLVGLKNVFQRQLPKMPREYIT
RLVLDKNHISMAIVKRGYRVVGGICYRPFEARGFAEIVFCAVDSSEQIKGYGSHLMNSLKDHVRKAHPTI
NVFLTYADNYAVGYFKKQGFTKEISYPRERWVGYIKDYEGGTIMQGRMLPKVKYMEVHQMLADQKAAIIA
KIKTLTKSHIIHPGLQIFKERQPDEEIKLTKEQVPGLGKLYLYISLCTHQRADTAIAESGWNPDLDDIVR
QPKRNPYHVLLQHVLNDLQNEPSAWPFVKPVDSSVVADYYDVIKDPMDLSTMEYKLENNHYESIEGFVAD
VKLMCANCRQYNGEKSTYTKQANLLEKALDRILKKRKSVLAD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: gcn5 mutant is avirulent in mice (O'Meara et al., 2010).
References
O'Meara et al., 2010: O'Meara TR, Hay C, Price MS, Giles S, Alspaugh JA. Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host. Eukaryotic cell. 2010; 9(8); 1193-1202. [PubMed: 20581290].