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CPS1

Victor ID 4728
Gene Name CPS1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. neoformans JEC 21
NCBI Gene ID 3255024
NCBI Protein GI 58261552
Locus Tag CNL06630
Genbank Accession AE017352
Protein Accession XP_568186
Taxonomy ID 214684
Chromosome No 12
Gene Starting Position 845975
Gene Ending Position 847766
Gene Strand (Orientation) -
Protein pI 9.42
Protein Weight 19330.89
Protein Length 182
Protein Note Supported by
DNA Sequence 
>gi|58271749:845975-847766 Cryptococcus neoformans var. neoformans JEC21 chromosome 12, complete sequence
TTTTGACTCGTATGCATTAGCACACCCCCCTTTAAAAGAAGGTTTCCGAATAACAAACATAAGACCCCGG
CATCCCCTCAAGAGCATCTCGGTTCCTCCACCCGTTCGCGCTAATATTAAGATTCCAGTCACCCTTCATA
AGGCATCATTTAAAATAAAAAAAGATGAATGAATAAACGAAAAGAAGATGAGGAGTCAAACATATAGACA
AATCAAACGAACTAAATAAATGACAAAAAGAGTAAAGAGGAAAGTAATTGATGAAAATAAACGGCTTGAA
AAAGGAAAAATCCTATCCACCAAAAAGGGGTATATTCTTTTGCTAGGTAAAGACATTGGAAAAGTCAACG
TAGTTTCGACATTGACAGTCAGGAATGTGGCATGGGGCGAGTTTTGCATTAAGTCGCATTCTGTAGCAGC
GGCATTTGGGAGAGTAAGATGTTTGTGTTCGGGGTTTGCGTTTTTTGTAGCTAATCGCGTATGGAGGGTC
ATTTTTCGTCTCGCTATAATATGTGGAACGGATGATCAAAAGGTATGAGGTGCAAAGGCCGGTATAGCAA
AGAATGAAAGTTGAGGAGGATAGAGGAAAAAAAGGCGGGAGGACGTTTGAGGGATTCGCGATTTAGACCT
TGAGGTTCTTGACGTTACTCGAGAGCCATTGCAATCCTTCAAACAACCCTTCTCCAGTCGTTGCGCAACT
GTACTTATGTCAGATGACAAGCGAGATAGGAGGGTGAGAAGGAGGAGGGTAAAAAAACGTACCTCGGGTG
GACGTACCACGACCTATCTTTCATTCGATGTAATCCAAGCTTTTCAGTGACCTCTGCTGGTGACATGGCT
GTGAATCCCATGTGAATTAGCGTAATTCTTTCATAAGCTGTGCCTCGCCCTTGCATTCCATCTCCTTTTT
CATTTTTTCCTTTCCAAAATACGAATGTCTTCTCACGCCCGTCTTCTCCCCGCAAGACATCAAATCAAAG
GCAAAAAATATGACTCACCGCCAGGTAAATCCTGTTTATTCGCAAATACCATCAACAGACACTCTCTCAT
CTCCCTGTCCGCCAAAATCCGTTCCAGCTCCAGTCGAGCTTCATCAATCCTGTCCCTGTCGCCAGAGTCG
ATCACAAAGATGAGACCTTGTGTGCCAGTATAGTAATGTCGCCATAACGGACGGATCTTGTCTTGGCCTC
CCACATCCTGTGCGAATTAGATCAGTACCGTGGGGGTCGAAGGAGAGGTAGGGAAAGATGAACGTACCCA
GACGTTGAATCTGACGTTTCGGTATGTAACTGTTTCCACGTTGAACCCGACGGTAGGGATGGTCGTGACG
CTTTGGTTGAGCTTAAGCTTATATAAAATGGCTAATGGAGACATCATACACATGTTCAGCTTCCAATAAT
TCCCAGCAAAATATGTAGATATAACGTACTCGTCTTTCCGGCGGCGTCCAGCCCCAACATCAGGATCCGC
ATCTCCTTGTTGCCAAATAACTTGCCTAGCGTCGTCAAGAAATAGTCAGCTATGATTGGTTTCGAAATGG
GTATTGCGTTGATCAATCCAGGACACACCAAGAGCTTTACTCAATTGCCCTCCCATGGTGAATACTCTTC
AAAGTGCGAGGCGGGTACAAAGGATCAGATGTTGACAGCGTCTCGTGCGAGAAGATGTAGCCGGACGCTG
ATGGGTTTACTCCAGAATGATTGCCGCGCCTGTAGTCGATGCCCGAATGTATTATCCAGGATTCTTGCAG
GGGGAGAACGACTGAGATGAAATGTGATTCTTCAATTATGAA
Protein Sequence 
>gi|58261552|ref|XP_568186.1| put. CPS1 protein [Cryptococcus neoformans var. neoformans JEC21]
MGGQLSKALGKLFGNKEMRILMLGLDAAGKTTILYKLKLNQSVTTIPTVGFNVETVTYRNVRFNVWDVGG
QDKIRPLWRHYYTGTQGLIFVIDSGDRDRIDEARLELERILADREMRECLLMVFANKQDLPGAMSPAEVT
EKLGLHRMKDRSWYVHPSCATTGEGLFEGLQWLSSNVKNLKV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: cps1 mutant is attenuated in C. elegans killing assay (Jong et al., 2007).
References
Jong et al., 2007: Jong A, Wu CH, Chen HM, Luo F, Kwon-Chung KJ, Chang YC, Lamunyon CW, Plaas A, Huang SH. Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection. Eukaryotic cell. 2007; 6(8); 1486-1496. [PubMed: 17545316].