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CLC-A

Victor ID 4726
Gene Name CLC-A
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii
NCBI Protein GI 29374036
Other Database IDs CDD:79366
CDD:144305
CDD:99705
CDD:73091
Taxonomy ID 178876
Gene Strand (Orientation) ?
Protein Name voltage-gated chloride channel
Protein Length 864
Protein Note ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has...; cd03684
Protein Sequence 
>gi|29374036|gb|AAO73005.1| voltage-gated chloride channel [Cryptococcus neoformans var. grubii]
MPRQQSEDEHRICGQAFRSPRSPQGNPLERNSKLEDEEELDLIRRYEDFSTVDWIQDSLHERTFQNKAPR
SRVIAQLDRSDGAIGYLWRLIRRTLEEGEAYVVISLVGVIIGVSAALISIITTWLSDIKLGHCTTGWWLS
RKFCCLEVSDELEACAEWKNWGGVEPFRWIAYVLFAAAFSFSAAYLVKNFAPYAAGSGISEIKCILGGFI
INGFLSVETFFIKGLTLPLAIASGLAVGKEGPSVHVACSVGNVVAKWFNRYERSHLKMREIVTASSAAGV
AVAFGSPIGGVLFSIEEMNQTYSNRTMWRSFVCALVATFTLASMDPFRTGKLVIFNVSYDRDWHYFEIPA
YVLIGIFGGLYGAFVIKFNVQMAAFRRKHLSGHGIFEAVALASITAIIGYLNGFLRIDMTEMLSVLFREC
EGGGDYNGLCQASSQWRMVNSLLLATIIRTVFIIVSYGCKVPAGIFVPSMAVGATFGRMIGILVKAMYNS
YPSAPWFAACAPDAPCITPGTYAFLGAAAAMGGITRLTVTVVVIMFELTGALTYILPTMIVLLVTKAVSD
QFGGGGISDHMIKFNGYPFLEKEDKEDPTDHAFIEPIANVMKKDLIILEATGVPLNHVVDIVQHTNYQGF
PVVKSHEDQTIVGFVRKNELRIALEKTRRVRNLSFNATCTFQCIRAIPEDAHELLERPDILIPNREGRMT
ANTGTENREDDGGEISHVDFGQYVDDIPLTVAPKMPLEIVMQLFRRMGPRVILVSDQGRLTGLVTVKDVL
RHELSEAHHRSRSTHTPITPSHPAYAQSNGWDTEWTVDDERGHGLEIVLEEGLEWTRSKATWAYGAALER
WRDIRGQDRRAATFDYELDEGIQG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: CLC-A mutant is attenuated in mice (Zhu and Williamson, 2003).
References
Zhu and Williamson, 2003: Zhu X, Williamson PR. A CLC-type chloride channel gene is required for laccase activity and virulence in Cryptococcus neoformans. Molecular microbiology. 2003; 50(4); 1271-1281. [PubMed: 14622414].