Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

CAC1

Victor ID 4717
Gene Name CAC1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Protein GI 12620209
Other Database IDs CDD:157704
CDD:177580
CDD:185802
CDD:176352
CDD:176844
CDD:29015
CDD:29062
CDD:144174
CDD:143636
Taxonomy ID 178876
Gene Strand (Orientation) ?
Protein Name adenylate cyclase
Protein Length 2271
Protein Note Adenylate cyclase G-alpha binding domain; cl07218
Protein Sequence 
>gi|12620209|gb|AAG60619.1|AF290191_1 adenylate cyclase [Cryptococcus neoformans var. grubii]
MPMFRRSASSHSTSDAAAPPTITNVTEGSPVSSGSITRQKRSRSHGGGGSPASTFSSRFGISRHLSHQFQ
QPHEQEQGQVPPPEKPATREVPVSLEPEIYGSEAGEDSNFGQEPAGEQLIPETRSSSRQSRRSSRELSVQ
TIEPSSDDEIRSPEKRRVSPLMKRLGEEPPFMLPHPSLSDSTYQAYPGVVIGSFAGGGPDTLFGNGMQLE
GTVDDILDPNAARQEDRGNQVPAGANIAPWLMDDGPPSRSENPSPALSETQERPVKGPAAALREKDPRKT
STVLNHFSSVPSLPKIRRHGRAATTTPDQTPRGSTHSQSNLASSSSSLNNESRESRAGSDDSIQTTLTQK
GRRQSPGEWGQASAVPPPSKGTRPGRFGSTASIISGTGSVGEKKKSLFGGLLKRKTNPNLSLNPISHDFT
TSEHRGSAGSIPLSASSSKLSSCSLSSLPSKSPPFTSPPEAFSRQFLPANYVHEGAVSPLQEISESPFHL
DMNLDDMEGIIDPAKAGLPSTVAYRPSASSEVTTDSSASESMRLEEALNQTSSFGTSVSGASRGSDGTKM
PGRIVLGEAERLPTPFTGTDPFQQHRESASTTGSDGKPFSPPSPHTLSPKHHLPSSSANQPRRPSALRNV
ETGQVDETPQLSASEGSIQPISPSWAGGSGITVFNDPFSTSRQRQEQPPNSAGLSPSTTAYPSAVTQPGP
STARFLITAGSTTPSAAWAAPESWGVEADEAPAEEITSSDEDDWAGLGVEEVASASPTSDTLPSPPTSPR
ASSLPSPKRAPPFGFKSQQRAKPGTSGTTDSTTSAAGRRKGKRVGSSGRPATGRPGTSGSAYNPSSLHWI
RIYRADKSYMLYNLPLNTSTGELLALLAAQAEQGMVRGKNVAINMKLYICERGQNRMLLPSEKPLTIQHR
RLLQLGHTEADHLDELGKNDMAVLCRFIYQAPILPIMDPEEESSYDSFEFIDIASRDLQTIPIFLHLHAH
DIIILNISKNPMTDIPLDFIQACTSLKELRMSNMALKRVPISIRASTTLARLDVSCNRIADLESVALHEV
ETLVSLKVQNNKLTSMPSYFAQMKSLKYLNISNNKFETFPSVVCEMSNLVDLDVSFNNIAELPAKMSDLK
SLEKLGLYSNDISKFPESFCTLANLRILDVRRNKITDLSAVYALPNLATLQADNNNIVTLDAQLGANVRQ
FSVPHNSVTRFTLAPPPNMAVVTYMLTNLDLSHGKISTLADEAFSGLTNLVTLNLNFNQFTKLPATLGRL
TSLEVFSCTDNMLNLVPAGFGKLQRLRMINLHNNNLKSLPEDLWACGALEVFNASSNLLDSFIPPPADIE
SVVGRVGSGTSQTSNGRKKYSVPPIGLSIRKLFLADNRLNDDVFHWISLMPSLRIINLSFNDIYEVPPFT
LCKCERLEALYLSGNKLTNLPSEDLEKLQSLKVLHLNGNKLQTLPSELGAIKTLQHLDVGSNVLKYNIAN
WPYDWNWNWNTSLRYLNLSGNKRLEIKPTSAHEMSHASSFRKELSDFTALTQLRVLGLMDVTLRIPSLPD
ESEEKRVRTSFSDINNMAYGISDMLGSIDNLAMFDLVVPHFRGKENECLFGMFGRVTTTLQGGKIAKYVQ
EIFAETLTAHLHQLEPGEEPSEALRRTFLLGDRKAFEFFSDKLQLEKERKPSWTSFASFDSMFRGWTPGV
NSVLRTGASGAVVYLVDKVLHVGSIGDTLVVLSRKGDAELLSKRHDPTDREESARIRKAEAWVSTKGFVN
DDKDLDISRAFGYWHECPAVNAAPEIRTRRLQESDEFVIIGNHALWQFCSYQTAVDIARTERDDPMMAAQ
KLRDFAISYGAEGNVMVMVVNVSDLFLAKGGRARGPSKQTATDANADVEGYAVAKRQVRRRYDEVGDRTL
NRLQQEIEPPVGQVAIVFTDIVNSTHLWETNPAMPTAIKMHHNLMRRQLRLDGGYEVKTEGDSFMVSFQS
VASALLWSFNCQIGLLQQEWPRELLEAHDGKVVYDSNGTIVQRGLRVRMGVHWGAPECEKDPITRRMDYY
GPMVNRAARINASADGGQLMASQDVLNEIAPLMEYLNSSDEQVLNDLQGDLKREVMELRRIGLEVRDMGD
RKLKGLEVPERLHLLYPKTLAGRLEISNEIRAEVEVNDARKSAERQRSVDIDQVYQLSDIALRLEAVCCY
NPTPSSPGDTPTAGVMRLHPPASYLGPSIREDMNDEELWTIIESLVGRIENVMSTLYLKNFGEFSAVLAA
LESATKIDQKLIVHALALMNEAMGKDEENAI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: cac1 mutant strains are avirulent in mice (Alspaugh et al., 2002).
References
Alspaugh et al., 2002: Alspaugh JA, Pukkila-Worley R, Harashima T, Cavallo LM, Funnell D, Cox GM, Perfect JR, Kronstad JW, Heitman J. Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans. Eukaryotic cell. 2002; 1(1); 75-84. [PubMed: 12455973].