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AOX1

Victor ID 4715
Gene Name AOX1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Nucleotide GI 20467244
NCBI Protein GI 20467245
Protein Accession AAM22475.1
Taxonomy ID 178876
Gene Strand (Orientation) ?
Protein Name alternative oxidase
DNA Sequence 
>gi|20467244|gb|AF502293.1| Cryptococcus neoformans var. grubii strain H99 alternative oxidase (AOX1) gene, complete cds
TATTCCGTCTTCCTAACATCAACCATGAATTATTTGAAGTGCGGCAATACGATAGAAACAACGAATGATG
TCCAATTTACAATTTCTTTCTTTGTCTACAATGTGTCAAGCAGATGGCAGAATACTGCTGCTGTCCACTC
CAATGTAAACAGCTTCTGAGTTCTGTGGGATTTCTAGATTCTAGTAGTCAAAGATATTTTGGTGGGTAAA
TTGAGGCCGTGCCAAGGCTCAAGCAAGACCTTTGGTCGTTTCATCCATCGTTATCATCCTTCGTGGACCA
TCCGTCATTCATCGCCGTATTACTACTGCACTTGCCGAACGAACGAACTGGAACACAAGAGCTTTAACCC
TTCCGCCTTTGCAACACCGTGCACGCTGAACTCTCATATGAGTACGGAGAACAGTCAACATACAGAAGGA
AGATTGATAATATTCTATTTATGTGGACAGCCAGCTCAGTTGGCATGAAAAAAGTGTTCAACGGCCATTG
AACAAAGTGGGGGACCATGAACGAACTGCGATATCTTCCGAACTTCTATACCCACATCGGAGAGAATCGC
GAAAGCGGTCGCCGACCAATGGGCGATGGCCAAATTGCAAACCGGGCAATTTGTCTCAGCTTGTGCTGTG
TTGCCCATTTGCCGTTAATTCCTAATCATTTTTAACACTCCTTTATCTATATCATCGGAATCTTTCGCAA
CTGTGAATCATATCTCTCACCATCTTACCAAATATTCGGATATCGTGGAGGTATCAACTGTCCGTACCAT
CACCTATTATACCCGGCACGGAAGTATGAAGAACCGCATTTGGTTTATCAACGGATCGACTCGGGAAAGA
GATCAATAATTGTGAAGTTTCCAAAGGAAAGGAATAGGCCATCTTGGCTGTTCCCATGACGAAAATTGGT
AGTAACCTTAATGAAATCAGGCGGCGAGATGAAAAATTGAACGGGTATATAAAGCTACCAATTGTTCAAG
GATGGATGCGATCGAAAACCAAAGTACAACTCAATTAGATACAATTCTCGCCATTACCTAGCGTTTACAC
TTCTGCTCCCCGATTATCCTCAGCAACCTACTATACCCAAACCAAGTATGTCTGCTATTATGCTGCGGTC
CGGCAACGTTGCCCGCTCCACCATCCTTGCCGGTGGACCTTTGATCGGCGGTCCAATGACCTTCCGCTCT
GCCGTTTCAAGCACTCGTACCTTTTCCCTTTTTACCAAGGCCAGGATTCAATCCGACGATATGAAACGTG
CTAGTTTGTCACTACAGCCCAGTGTAAGGGAGGCAGAGAAATCTCAAGGGCCTGTAGTAGGATCAGAAGG
CAGGGAGGTGGAAGGCCCTCACTATCAAGGTAAGCAACACCACTTACATTGACCAAGAGAATAGAATGCC
GACACCTGCACTATAGATCAAGTTTCGCACAATGTATTGTCGGATGCTTCGACCACCGGCGCTTGGACGA
TGCTCAATCCCATTTACACCGAGAAGGTAAGCTTCCCGTCGATGCCGTCTGAAAAGTAGAACCTAACTGC
TGCTAGGAACTCAACACCGTTCAGGTCGTGGGAAGAGCACCTGTTACATTTGGCGACAAAGCAGCTCACA
GGACCGTCAAGTTCCTCCGCAAATGCTTCGATTTGTTAACCGGTTACACCCCCTATGAAGTCCCCGCTTC
TGTACTTGCTCAGAAACCCATACCCATCGCCGAGTTGCGCTCCAAGGGCAAGCTTTTGTCCGACCAGAAG
TGGCTATTCCGAATCATCCTTCTCGAGTCCATTGCCGGGGTACCCGGCATGGTCGGCGGAACCTTGAGAC
ATTTGAGGAGTATGAGGTTGTTGAAGAGGGATGGTGGATGGATACATTCATTGTTGGAGGAGGCTGAGAA
CGAAAGGATGCATCTTCTGTAAGTTCTGTTTTGAATTCCAACTCTTCACTTCGCTGATGAAACCTCCAGC
ACATTCATGACCATTGCTCAACCTGGCATCTTCACTCGGGCGCTCGTTTTAGCCGCTCAAGGCGTCTTCT
ATAATGCTTTCTTCCTCACCTACCTCATATCCCCCAGGATCGCCCATCGATTCGTTGGTGCGCTTGAAGA
GGAAGCTGTTCGTACCTACACTCATTGTATCTCCGACATGGAGGCTGGCCTTATCCCCGAGTGGAAAGAC
ATGCCTGCACCTGCCATTGCTATCGACTATTGGAGATTACCAGCAAGCTCGTCCCTTCTCGATGTGATCA
GGGCTGTTCGGGCCGATGAAGCTACCCACAGGTTTGTCAACCACTCTTTGGCCAACTTGGATCAAAAGAG
GGACTTCAATCCTTTCGCATTGTCAGAGGCTAGTCCCGAGGAACGTGGCAGCAAGTGGGGGTGAGTGACC
TTATATATGGGCCTTAAATGGAGCTGACTGTGGGTATTAGCTACACACGAGAAGAGTCTGCCAAATTTGC
TCTGGAACAGCAGCGAAAACTCATGGCTGCCTCTGAAAAAAGCTCAGGACTCGTTGAGTGATGCTCAAAT
AAACAACTATCATGTTTTCAATTAATATCTATATCATTATATATACTGTTCGGCATTATTGTACGTAGCA
TTATACCCTTCAAACTGTCCCATTCTCTACTGCAATCGGGTTCCGGTCGTCGATGCATCCTTGTCTCTGA
AATTTTAAAGCCGGTCATTTTCCGTTGTAAGATTTGGCGTTGGCAGTACGCACACGCTGATAAAAAGCGG
AGGTACGTACAGAGATAAGCCCGCAGCCAGCGGGAACCTTCGGATCCTGGAGCTAATAGACTGTGCACTA
ATCAACGGGCATGAAACCTATCTCCGCCTTATCTTCTCCACTTCCTTCGGTCATGCATCTCCGTCCGTCG
CTGGTACTAATAGTAGTTTGCTAATAAGTAAAGCAGCAGCATCATCAGATATCCACAGCTTCAATTACCC
TACAACAGCAACTGATTAGCAGATATTTTCGTTGGTAAACCATAATTGACGACTACTATGACCAACGCCG
CTACCAATCTTCTCTTTAAACAGGCGACCATTGCAGGAGCCCAAGTGCCGCCTATGGCCATCGGTGAGTA
TCTAGACCTTCGTAATATTGAGCTAGATTGCAGAGGTGACCGGCTATATCCCTAGGTACTTGGTCTTGGG
GAGATAAAACTTGGGGCTATGAATCCAAAGACTTCGAGAATGTTAAGGAAGCGTGGAGTGCTTCTGTGAG
AGCTGGATTGACCTTCTTTGACACTGCGTTAGTGTATCATTATCTGATCAGCTATATTGAGGTTGATTCA
TTCATCAGTGAAGCCTACGGTAACGGTGAATCAGAAAGAATTATTGGCCGTCTTATCAAAGAAGAAACGT
CTGAAGAAAATAAAGCTAGACTCTACATTACCACCAAATGTACGTCCATTGCTATCATCAATGCACCAGA
GCCTTTTAAATCCTTGTAACCCAGTCCTTCCTTTCCCAACCAGGAATGGATTTTTTTTCTTCAACCC
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The aox1 mutant strain was significantly less virulent than both the wild type and the reconstituted strain in the murine inhalational model, and it also had significantly impaired growth within a macrophage-like cell line (Akhter et al., 2003).
References
Akhter et al., 2003: Akhter S, McDade HC, Gorlach JM, Heinrich G, Cox GM, Perfect JR. Role of alternative oxidase gene in pathogenesis of Cryptococcus neoformans. Infection and immunity. 2003; 71(10); 5794-5802. [PubMed: 14500501].