Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

ADE2

Victor ID 4714
Gene Name ADE2
Sequence Strain (Species/Organism) Cryptococcus neoformans var. neoformans B-3501
NCBI Protein GI 4063512
Other Database IDs CDD:178534
CDD:164032
CDD:153673
Taxonomy ID 40410
Gene Strand (Orientation) ?
Protein Name phosphoribosylaminoimidazole carboxylase
Protein Length 582
Protein Note phosphoribosylaminoimidazole carboxylase
Protein Sequence 
>gi|4063512|gb|AAC98316.1| phosphoribosylaminoimidazole carboxylase [Cryptococcus neoformans var. neoformans]
MAPRKTVGILGGGQLGRMLTHPAALLGIPLLILDSGSYTPAKQTLLPPPPHSHPDGPFTSETHIRKLASA
CDILTVEIEHVNADVLEAVEKEGLCEVQPSPKTIRLIQNKYDQKKYLAERGVAVAPFEELPANPTEEDFK
AIAGRLGLPLMLKAKTLAYDGRGNSPLKSASSEDIQASLKFLGDRPLYAEGWAPFVKEVAVMVVRNKEGE
VQSYDAVETIHRESILRVCLTPLRGEKGVNQRARELAEKAVGHLEGAGIFGVEMFLMPDGELLLNEIAPR
PHNSGHHTIEACLTSQFENHLRAILSLPLGSTALRVPSAAMVNILGASSTMDAIDKMADNALTVPGAAVH
LYGKAESRKARKMGHITVTAESDAELNERLRALLFAQPDAHADWIDLIAPPSPAPAHSHAKPLVGIIMGS
DSDLPVMHPATKILEKFGVPYELTITSAHRTPERMVKYAKTAADRGLRAIIAGAGGAAHLPGMVASETSL
PVIGVPVKASVLDGVDSLYSIVQMPRGIPCATVGINNSTNAALLAVRILGTSVPALNKATEEYSKALEEE
VLAKVDILEEEGWDKYIERLKK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ade2 mutant is attenuated in central nervous system model in immunosuppressed rabbits (Perfect et al., 1993).
References
Perfect et al., 1993: Perfect JR, Toffaletti DL, Rude TH. The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid. Infection and immunity. 1993; 61(10); 4446-4451. [PubMed: 8406836].