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acs1

Victor ID 4713
Gene Name acs1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. neoformans JEC 21
NCBI Gene ID 3253764
NCBI Protein GI 58259419
Locus Tag CNA07740
Genbank Accession AE017341
Protein Accession XP_567122
Taxonomy ID 214684
Chromosome No 1
Gene Starting Position 2137289
Gene Ending Position 2140206
Gene Strand (Orientation) -
Protein pI 6.32
Protein Weight 70418.34
Protein Length 680
Protein Note Supported by
DNA Sequence 
>gi|58271746:2137289-2140206 Cryptococcus neoformans var. neoformans JEC21 chromosome 1, complete sequence
GCAGAATGATGGTTTTGCATATCCAAGTGACTTCTCACGTTGCATTCTTCCATATAATGGATTTCTCGAC
CAAAATATGAAACATATGCCCAGACGAAAGAATATTGAGAGCCCAAACTAAAGATGCGTACTAGTACATT
CCTCGCACTTCTTTTCTTCCCTCCTATCCTCCTATGCCCTTGCGCATGTGACACGTCCCGCTACATCTGT
TTCCGCCTGTAAGGAAATTAAGCAGAGCCGGTAACCTTTCGCTTGACTGTGAATAGGGATCAGCATTCAG
ACAAAATCCATCAAACAGGGCTGAAGACTCACCTTCGTCGACAATTTGGGGGTCAGCAATGGAAGAAAGA
TCTCCCAGTTGGTCACCCTCGCCAGCGACAATCTTTCGGAGAATTCGACGCATGATTTTCCCTGATCGGG
TCTTGGGGAGATCGGAAACAAGGTACTGTAATAGTCATCAGTAAAAAACCTTTTCGACTGGATGGCGACA
CTTACAATCTTCTTGGGAGCAGCGAAAGGACCAATAACTTTCCTAACCTGGATAGCCAACTCCTTGCTAA
GATCCGCCTCCTTGGTACTCTTTAAATCGAACTCGGGCTTCATCGTAACGAAAGCGTACACAGCCTGACC
GGTAAGGTCATCAGCGCATCCAACAACGGCAGTCTCGGCGACACCCTTGTGGAGGATAAGGGCAGACTCA
ACCTCGGCGGTGGAGAGTCGGTGGCCAGACACGTTGATAACATCATCAACTCGTCCCTTGATCCACATGT
AACCGTCATAGTCTCGGGCAGCACCGTCACCAAAGAAGAAGTAGCCGGGGTAAGGCTTCATGTAAGTCTC
AAGGTACCTCTTGTGGTCCCTGTAGACGGTCCTGGCAATACTAGGCCATGGCTTCCTGGCAACGAGAACA
CCCTCCACATCGTTACCCTCCAAGACCTGACCAGTTTGAGGGTCAATGATGTCAACATCCATACCGAAGA
AGGGGAAGGTGGCGGAACCAGGCTTGGTGGAGATGGCTCCAGGGAGAGGAGCAATAGAGATGGAACCAGT
TTCGGTCATCCAGTAAGTATCAACAATGGCACATTGGTTCTTGCCCGCAAAGTCATTGTACCAATGCCAA
GCCTCGGGGTTGATGGGCTCACCAACAGAGCCCAACACTCGGAGAGAGCTGAGATCGTGGTTCTTGACGT
GGTCCTCGCCCATACGTCTTAACAATCGGATCGCAGTAGGCGCAGTGTAGAGCTGAGTAGCCTTCCATTT
GTCGACAAAGTCCCAGTATCTGGATGGTGTGGGGTAGACGGGAGTGGATTCAAAGACGGCGGTGGTGATG
CCGTTGGCGAGAGGGCCGTAGATAATGTAACTATGTCCGGTAATCCATCCGATATCGGCCATACAGGCGA
ATCGGTCATCCGGGTGAGCGTCAAAGACGTACTTGAGGGTAAGGGCGGCGCCGAGGAGGTAACCACCGGT
GCAGTGGACGACACCCTTGGGCTTACCGGTGGAACCAGAGGTCTACGAAGCGTTAGTCCTAAAACTGCAT
TGGAAGCTAGGAAACAATTCACGTAGAGGATGAAAAGAGGGTCCTCGGAAGCCATCCTCTCGCAAGGGCA
GTAAGCGGGCATCTTGGCACACTCTTCGTCCCACCATTTGTCACGACCTTCAGTCATGGGGACCTTGTTG
CCGGTTCGTCGAAGGACGAGAACGTTCTCAACAAGGGGGCACTGCTGGAGAGCGGCATCGACGACTGAGA
GGTGTAAGTTGGAATTTCTACAATAAAACAGATCGACCTACTTTGCTTAGTAGCAATACTCTTACCACCT
CGTCGACCCTCGCTAAAACATCATTAGCTTTATATACTACAAATTTGTTCAAAAATTCGACCTACTCGGT
GGTGATCAAAACCTTGCATTCACAGTCATTGACTCTATCCCTCAAACTCTCGGCGCTAAAACCGGCAAAG
ACAGCAGAGTGAATGGCACCGATCCTGGCACAAGCAAGGAACGCAGCAGCGGCTTGCCAAGTCATGGGAA
GACTTAATGTAGCCTGTCAGCTACTGAGACTCGATTTTCAAAGAATCCATTTTCCTGGCTGCAACTCACT
AGATGGACACAGCGTCACCCTTCTTGACACCGTAGCTCTTGAGGACATTGGCAACTCGGCAAGTCTCCTG
CATGAGCTCCTCGTAAGAAATCTCACGGGACTCAGAGGGCTCGTCGGCCTCGTAGATGATGGCGGTCTTT
TTCGGGTTCTTGTAGAAGTGTCGGTCAAGACAGTTGTAAGCAGCGTTCAAGGTACCTTCGGGGCTGCAAA
GTCATCAGTCAAATCATCCACACCCAGAGCGTTCCCACATTTCACTCACAACCACTGAATGTCTCCGTGC
TCAAAGCCACCGGCCCTGACAGTCTTGAAGTCCTCATACCAATCAAGAGTCTCCCTGGCCTTTGCGGCCC
ACCACTCATCATTATTGGGACCAACAGTCTTGGCCCATTCATTGACGTAGGCCTCGTAATTGGGACCAAG
GTGAGGCTTCGGGCGGCCTTCCTTGCCCTGCATACGAGGAGGGGGAGCGAAGAGGTCCTCAGACTCGGGG
ACGGAGTCGGGGAGAGGGTGAACGTGGTGGACGCCGGGTGCAACTTCTGTCTTGCCCATGTTGACTACTG
ATATGTGGATGTTGCGTAGAGCACGTGTACGGAATAAAGTTAATATGCGCTGTTGTGTGCGGCGGAATTA
ATTGTTGGGGAAACGGGGACGGTTGTCAGCGGAGAGTGGCTTGACCCGTTCGGGAGCGGGGGGCTTACCT
TTCGTATTGGTATTTCGGCGGTCTCCTATAAGTTATGTACTAATACTTGTATTGCTGTTGCGCCTGTCAC
TTGTGGTACTTCTGGGTGTTCCTTGCTACAACGTATGCCTGAATACAA
Protein Sequence 
>gi|58259419|ref|XP_567122.1| acetate--CoA ligase [Cryptococcus neoformans var. neoformans JEC21]
MGKTEVAPGVHHVHPLPDSVPESEDLFAPPPRMQGKEGRPKPHLGPNYEAYVNEWAKTVGPNNDEWWAAK
ARETLDWYEDFKTVRAGGFEHGDIQWFPEGTLNAAYNCLDRHFYKNPKKTAIIYEADEPSESREISYEEL
MQETCRVANVLKSYGVKKGDAVSIYLPMTWQAAAAFLACARIGAIHSAVFAGFSAESLRDRVNDCECKVL
ITTDEGRRGGKSIATKQIVDAALQQCPLVENVLVLRRTGNKVPMTEGRDKWWDEECAKMPAYCPCERMAS
EDPLFILYTSGSTGKPKGVVHCTGGYLLGAALTLKYVFDAHPDDRFACMADIGWITGHSYIIYGPLANGI
TTAVFESTPVYPTPSRYWDFVDKWKATQLYTAPTAIRLLRRMGEDHVKNHDLSSLRVLGSVGEPINPEAW
HWYNDFAGKNQCAIVDTYWMTETGSISIAPLPGAISTKPGSATFPFFGMDVDIIDPQTGQVLEGNDVEGV
LVARKPWPSIARTVYRDHKRYLETYMKPYPGYFFFGDGAARDYDGYMWIKGRVDDVINVSGHRLSTAEVE
SALILHKGVAETAVVGCADDLTGQAVYAFVTMKPEFDLKSTKEADLSKELAIQVRKVIGPFAAPKKIYLV
SDLPKTRSGKIMRRILRKIVAGEGDQLGDLSSIADPQIVDEVKRKVTGSA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: acs1 mutant is attenuated in mice (Hu et al., 2008).
References
Hu et al., 2008: Hu G, Cheng PY, Sham A, Perfect JR, Kronstad JW. Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection. Molecular microbiology. 2008; 69(6); 1456-1475. [PubMed: 18673460].