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KEX2

Victor ID 4703
Gene Name KEX2
Sequence Strain (Species/Organism) Candida glabrata
NCBI Nucleotide GI 13183374
NCBI Protein GI 13183375
Protein Accession AAK15173.1
Taxonomy ID 5478
Gene Strand (Orientation) ?
Protein Name Kex2 proprotein convertase
Protein Note subtilisin-like serine protease
DNA Sequence 
>gi|13183374|gb|AF292937.1| Candida glabrata Kex2 proprotein convertase (KEX2) gene, complete cds
CGATGCTGATCACTGCAGCCCATGTCGACGACGATGGGAACCCAGTGAGATTCTGCGTCGAGAACTCATG
GGGTAAGGACTCCGGCAAAGATGGTATGTACGTGATGACTCCAGAATACTTTGAAGAATACTGCTACCAA
ATCGTAGTCGACATAGATGAGTTGCCAACCGATCTAGCTGAAAAATTCGACGACAAAGAACCAATTGTCC
TGCCAATTTGGGACCCAATGGGCGCACTAGCAGAGTAAGTACACAGCAGCAGAAGAATATAGAAACTTAA
ACTAAATATCAATACATCATAAAATAGGTAAATAAAATAAAAAAGAAATTGCTATTCAATACTAGGCATA
GTCACATGAAGTGGACGTATCAGATAACTGAGAGCTCTCCTATCTCCGTTCATTAAAAGACCTTCTATTT
TGGGCTTTTCAGACACACACGAAAGTGCAGAATAACGAAAAGCCAGACGTGTTTATTGCTTTTCCCTGAG
AATCTGCACATCCCGCAGGAACCAACGAATAGCCCAAAGTGATCATATGAACACTTTTAATATGGTATAC
TAGCAAACTCTTATGTCTTATATCTGTGACCGCTCTTGGCTGACTGTGTGATCGTTCCTTGGAAGTGGAC
GAGACGAGAAGTAAGCAAAGGGTAGTGGATATTGAGACACAGAGTTTTGAACCACAATATATTTGAGGAA
AAATTGATTAAATTAGCTCAGCTCTCTTTACAATAGACCCAATACAAGTTGAGATAGGACATCTCTTCAC
TGTGTTTTATTTGAAGATACAGAAACTTCAAAACTTTCACCAAGAAGACGGTTTGATAATACTTCCTGGA
AAAGAGGGAAAGGGAAAGAGAAAGCCAGTATGAAGTGGTGGAACAAGGGTTGCATATACCTGGCGTATAT
CACACTCATATCGAAAAATAGCAATGCAGAGCTCATACCTGCGAAGAACTTCACATCTAGAGATTATTTT
GCTGTTGAATCTCATCTATCGGCGGCGGAGTTATCCAAATTACATCCAGATTCGATATCAATGGGGGGGG
AGTTATCCAAATTACATCCAGATTGGACCTTTGAACATCTGGTGAGGGGTCTAGATAACCACTACGTGTT
TTCGGTTGCTAAATCCGAGAATGAGGATGACATAGACTCAGGCAACTCTTTGAGGAAGAGAGCTATTGAA
AATGAGGATCATATCCTATCGTCTGAGTTTTTAACACCTTCAAATAAACTACAGAAAAGGATGCCCGTAC
CAGCACCTCCTCTAGATTCTAGCATGCTGCCGATACAAGAAATCAAGGATAAAATAGGCATCAATGATCC
ATTGTTCCCCAAACAGTGGCATTTAATAAACCCAGCATTCCCAGGGAACGATATAAACGTAAAGGATGTC
TGGTTGCAAAATATAACAGGTAAAGGTGTAGTTGCCGCAATCATCGATGATGGTGTTGACTATACTAGTC
CGGACTTAAAAGACAATTTCTGCAAAGAAGGATCGTGGGACTTTAATGAGAATCAACAACTCCCAATGCC
TCTTTTGAGCGATGATAACCATGGTACTAGATGTGCTGGTGAGATTGCTGCAATAAGAAATAATAATTAC
TGTGGTGTTGGCGTTGCATATGATGCAAAAGTCTCTGGAATTAGAATATTATCAGGCCCTTTGACAGCAG
AAGATGAAGCTGCTTCTCTAGTCCATGCTTTAGACGTTAATGATATATATTCCTGCTCCTGGGGACCTAC
AGATGATGGAAAACATTTACAAGGTCCCTCACCTTTAGTTAAAAAGGCAATGAAAAAAGGTGTCACAGAA
GGAAGAGGCAATAAAGGTGCAATTTATGTATTTGCTAGTGGTAATGGTGGCATGCATGGTGATAATTGTA
ATTACGATGGGTACACCAATTCTATATATTCAATTACAGTTGGTGCCATCGATCACAAAGGTTTACACCC
ACCGTACTCCGAAAGTTGTTCAGCAGTACTTGTTGTCACCTATTCGTCTGGCTCAGGTGAATATATTCAC
TCTACAGATATTAATGGTGGCTGCTATGATAGGCATGGAGGTACTTCTGCTGCCCCCGCCATTGATACTC
GAATTTATGCACTTGTCTTGGAAGCTAATCCAAATATTACGTGGAGAGATATGCAATATTTATCAATTCT
TTCTTCAGAAACAATTGAAAATAACCTTGAGGATGGTGACTGGCAAACCACTAAATTGGAGAAGAAATAC
TCACACAAATATGGTTACGGTAAGTTGAATGCTCACAATATAGTTGCTTTGGCGAAAGATTGGGAAAACG
TTAATCCACAAGTAGAATTTGCCACTGATATTAAAGAAGTGAATGAAGAGACAGACAAAGAAGATAAACC
AATTGAATCGACAATCGAAATTACTGCATCAGATCTGGAGAAGGCCAAGTTCAGATCTGTTGAGCATGTC
ACTATTAATGTTGATATTAGCACTGAAAATAGGGGCACAACGACAATTGATCTAATATCTCCATTTGGTG
TAGTATCTCATCTAGGTGTTGTTAGACGCAAGGATGACTCCAATGAAGGCTTTAGAGACTGGACGTTTAT
GAGTGTAGCTCACTGGGGAGAACTTGGCTCTGGTGAATGGAAATTGATAGTAAAAACTACCTCTGACGAC
GACAAAGTCGAGTCTCATAGCTGGAGTATAACACTTTTCGGATTGTCGGAATACTCAGAACAGAAGTTAA
AAGAAGGTGACATACCGTCAGAGAACGATGATGATAACCGAAAGGAGGATGGTCCAGGAACTGATAATAA
TAATGTTACCGAGGAAACAGGGTCTGATCAGCAACCAGAAACTGAAAACCCTGAAAATGATGGAGATAAT
GGGACGGATAAAAATACTGGCCATCACATGACGCCAACTATCCCAACTGGTGTTCATTTGATAGTATCAA
TTTTCATTATTGGCTGTGTGTTCTTACTCTTACATTTTATGTTTTTTGTTAGAACGCGTAGAAGGATAAA
AAGAGTAAGAGCCAGCAACTACGATTATGATGTGATCGATACAGATGCAGAATATGATTCTACAAACGAA
TCGTCATCTACTCCTCTTCCGGATACATTCAGATTATCTGATATCGATGACAACGAGTTTGATATATCAG
ACGAAGAAAACACTCAATACAATCATTTGTTTAATAATGATGAATCGCTGGATCAACGTCTATTGGATTC
CGATAATCCAGAACAAAACCCAACAGGCGAACAAGCACAAACACATTCATCTGACACATAAATATATAAT
AAATATGGCATGAACAACACCAAGTATGTTGCATATTGATAATCTCTATATACCTGCTATATCAAGCATC
ATTAGCATAATTAGATGAACGCAATATACTTAACTAGCATAAATCAAGATTAATATCACTAGAATTACCA
TATATATTACCCTATAATATGAGCGGTGACTTATTATAATATAGCGCGTCTGCAATAACGTCTAATCCAT
AACCCTTTGTAATATATAGTGTTTCGCTATACATTCAACTATCGTTTTCATAACATAAGTGCTTTTTGCT
AGAATCGAACTCCTGTTCACGAACTTTTTCAAGAATTGAGACTGAAAATAAAAAGGTCGTAGGTGTGAAA
AGATATCCGCATATAGTGCAACTCAGGTACTACCACATAACTAACAACAACTCAACACGATAGCAATAAC
AATCAACTCACTTCATTTGAGAATATTAGTTGCAGAGTTAGAAAGTGTGCTAGACTTCATATTTACTGTT
AGTTTTCGACAGTTTTAACTAGTCAACAGTTTCATTTACTACACTTGGACACCTGTTTGATAGATATCTG
TTCAGACCAATCATTCAGCGTTGGGATAGACAGAACAGGTCTTATACTACTCTAATTATATACAATAGTG
GAAATCCAAAAAGGCTGCTGAAATATCTCAGTATAAAAGAAATTGAGTTGATCTTAAATATGTGTGAACT
GAATAACAAACGGGTATCTTGGTCAAAGACAGGACTAATCGCATATGCTGATGAACAGTCTACTTATGGA
AACCTCTGCATATCATTTTTGGAAACAATTAATGGCGTTAACTGTAGATTTCATCCACCACAACGATATG
TTATACATCCTCAATTGCATGAAGTACCTTTAAAAACAGAAACAGGTAATGGAATAAATGGTGCCTCAGG
GTCCAGTACAGCGCAATCAAATATTCATGGAACGACAAGTGTACCCGGCTCCGCAGGGAAACACCAACAT
CAATTTTTCTATGATATCTCATCAATTCACTGGAACAATTGGTTCAGTTTACCAGGCGACATGCTAGCAG
TATGCGATGAATTGGGAA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: kex2 mutants showed reduced tissue damage in the presence of itraconazole compared with the control infections (Bader et al., 2001).
References
Bader et al., 2001: Bader O, Schaller M, Klein S, Kukula J, Haack K, Mühlschlegel F, Korting HC, Schäfer W, Hube B. The KEX2 gene of Candida glabrata is required for cell surface integrity. Molecular microbiology. 2001; 41(6); 1431-1444. [PubMed: 11580846].