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FTL_1458

Victor ID 461
Gene Name FTL_1458
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3952032
NCBI Protein GI 89256747
Locus Tag FTL_1458
Protein Accession YP_514109.1
Taxonomy ID 119857
Gene Starting Position 1381542
Gene Ending Position 1384262
Gene Strand (Orientation) -
Protein Name preprotein translocase subunit SecA
DNA Sequence 
>gi|89255449:1381542-1384262 Francisella tularensis subsp. holarctica LVS chromosome, complete genome
ATTACTCAACCTTACCATGACACTGTTTATATTTCTTACCTGAGCCACAAGGACATGGATCATTTCTTTT
AACTTTTGGACCTTCTCTTCTAACTTGCTGAACTTTTGGAGCCTCTTCTTGCTCATCCTCATCATGTCTT
TGATTGTTATCAATCACACTTTCATGCTCAGCTTTAATATCACTCATAGATTCTTGCCATTCTTGCTGAG
CTCTTTGCGTTTCTTCTTCAGTAGCAATTCTAATCTTAGCAAGTGAAGATATAACCTCATATTTGAAATT
ATCTAACATAGTTGAGAAAAGCTCAAAGGCTTCTTTTTTATACTCATTTTTTGGATCTTTTTGAGCATAA
CCACGTAGATTTATACTATTACGTAAATGGTCTATTGAACTCAAATGCTCACGCCAATGAGTATCAAGAG
ATTGTAATAATGAGAATTTCTCAAATTGTCTCACAGCGCCTGAATCTAAATTCTTGGTTTTTTCAACAAA
TTCAATTTCTATAGCTTCTCTTACTAGCCTCTTAAGATCTTCTTCTCCTAAGCTATCATCTTCTTCATAA
AGCTTCTGTAGATCAAGCTCAATCATAAAGTCAGATTTAAGTGCCTTCTCTAAGCCTTCAAGATCCCACA
GTTCATGCATGGAACCAGCAGATACATAATCATGAAACAACTGCTCAGCCACATCAATACGAATATCAGC
AAGAATATCACTAACATCTTCAGCTTCTAAGAATGACTGTCTTTGCTCATAAATAACTTTACGTTGTGTA
TTAACAACATTGTCATACTCTAATAGATTCTTACGGATATCAAAATGATAACTCTCTACCTTACCCTGTG
CTTTTGATATAACTTTTGACATAAACCCAAAAGCTAGTGACTCACCACCTTTTAGACCTTTTTTAACCCT
TTCTGCCATACTTTGAGAAGCAAAAATTCGCAAAAGATTATCATCCATAGATAGATAGAATTTACTCTCA
CCAGGATCACCCTGACGAGCAGCACGACCTCTTAGCTGATTATCGATCCTGCGGGAATCATGTCTTTCTG
AACCAATGATACATAGTCCACCAGCTTTCTTAACAGCTTCATTACGCTTTAACCATTCTGCTTTTATTTG
AGCAATATCTTCTGGTGTAGGATCCTCAAGCTGTGCTATTTCAACCTCTAAATTACCGCCTAAAATAATG
TCTGTACCACGACCTGCCATATTCGTTGCGATTGTCACATTATCTGGGTAGCCAGCCATGGCAATAATAC
TAGCTTCTTTCTCATGTTGTTTAGCGTTCAAAACATTATGTCTGATTTTTTTCTTTTTCAACAACGTTGA
TAATACTTCAGATGCTTCAATAGATGCTGTACCAACTAGTACCGGCTGACCTTTTGAAATTCTCTCCTTA
ATATCCTCAACTATAGCATCAAATTTTTCTCTTACACTACCATATATCTCATCATGATGATCTTTTCTAA
TCATCGGTTTATTAGTTGGTATAATAATTACCTCTAAACCATAGATAGAATGAAGCTCAAATGCCTCAGT
ATCAGCAGTACCAGTCATACCAGCAATTTTGTTATATAATTTAAAGAAATTTTGGAAGGTAATAGATGCC
ATTGTTTGATTTTCAGCATTAATTTTGACGCCCTCTTTAGCCTCTATTGCCTGATGCAAACCATCTGACC
ATCTGCGACCAGGCATTGCCCTACCAGTACTTTCATCAATAATAACTATTTCCTGATCTCTCACAATATA
ATCAATATTAAGTTGATACAACGAATGAGCTCTTAGACATGCATTTAAGTAATGCATTTTTGTAATATTG
TGAGGGCTATAAAGGTTATCATCTTCTTCAAGAATACCTTCTTTTTTGAGCATATTCTCAATTTTTGCAT
AACCTTTTTCAGTTAGATAAGCATTTTTGGATTTTTCATCTACATAAAAATCTCTTTGCTCTTGTTCATT
TTCAACTTCTTCTTTTTCTTGCTTTTCTAAGTACGGAACTAATCTATTGAAAAGGTTATACATCTCAGAG
CTATCATCTGAGGCACCTGATATGATAAGTGGTGTTCTAGCCTCATCAATCAAAATTGAGTCAACCTCAT
CTATGATTACATAGTTACGGCTTCTTTGAACTTGCTGCTCTTTTTCATAAGCCATATTATCTCTTAGATA
ATCAAAACCAAATTCATTGTTTGTTCCATAAGTGATATCACATGCATAAGCTTCTTTACGTTGCTGGGGA
TTTAAATCAGCAACTATTACACCTACAGACATCCCCAAAAATTCGTAAATATCACTCATTAGCTCAGCAT
CACGCTTAGCAAGGTAATCATTAACTGTAATTACATGTACACCATCACCAGTCAAAGCATTTAGATAAGC
TGGTAATGTGGCAACTAAAGTTTTACCCTCACCTGTTTTCATCTCAGCAACTTTACCTTGATGAAGAACT
ATACCACCTATCAGCTGAACATCATAATGACGCATATTTTTAGTACGCTTTCCAGCTTCTCTAACGGTTG
CAAAAGCTTCTGGCAAAAGATTGTCTAATATTTCACCGTTTGCAAGTCTTTCGCGATATTCAAAAGTTTT
TGCTTTTAATTGCTCATCACTAAGTTTCTCAAACTCAGGTTCTAAAGAGTTAATTTTTTGAACTATTCTA
GAAACTTTTTTTATAAATCTTTCGTTACGACTACCTATTATTTTCTGTACTAAACTTAACA
Protein Sequence 
>gi|89256747|ref|YP_514109.1| preprotein translocase subunit SecA [Francisella tularensis subsp. holarctica LVS] MLSLVQKIIGSRNERFIKKVSRIVQKINSLEPEFEKLSDEQLKAKTFEYRERLANGEILDNLLPEAFATVREAGKRTKNMRHYDVQLIGGIVLHQGKVAEMKTGEGKTLVATLPAYLNALTGDGVHVITVNDYLAKRDAELMSDIYEFLGMSVGVIVADLNPQQRKEAYACDITYGTNNEFGFDYLRDNMAYEKEQQVQRSRNYVIIDEVDSILIDEARTPLIISGASDDSSEMYNLFNRLVPYLEKQEKEEVENEQEQRDFYVDEKSKNAYLTEKGYAKIENMLKKEGILEEDDNLYSPHNITKMHYLNACLRAHSLYQLNIDYIVRDQEIVIIDESTGRAMPGRRWSDGLHQAIEAKEGVKINAENQTMASITFQNFFKLYNKIAGMTGTADTEAFELHSIYGLEVIIIPTNKPMIRKDHHDEIYGSVREKFDAIVEDIKERISKGQPVLVGTASIEASEVLSTLLKKKKIRHNVLNAKQHEKEASIIAMAGYPDNVTIATNMAGRGTDIILGGNLEVEIAQLEDPTPEDIAQIKAEWLKRNEAVKKAGGLCIIGSERHDSRRIDNQLRGRAARQGDPGESKFYLSMDDNLLRIFASQSMAERVKKGLKGGESLAFGFMSKVISKAQGKVESYHFDIRKNLLEYDNVVNTQRKVIYEQRQSFLEAEDVSDILADIRIDVAEQLFHDYVSAGSMHELWDLEGLEKALKSDFMIELDLQKLYEEDDSLGEEDLKRLVREAIEIEFVEKTKNLDSGAVRQFEKFSLLQSLDTHWREHLSSIDHLRNSINLRGYAQKDPKNEYKKEAFELFSTMLDNFKYEVISSLAKIRIATEEETQRAQQEWQESMSDIKAEHESVIDNNQRHDEDEQEEAPKVQQVRREGPKVKRNDPCPCGSGKKYKQCHGKVE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: a FTL_1458 mutant was attenuated for infection in a mouse lung (Su et al., 2007)
COG COG0653U, under U: Intracellular trafficking, secretion, and vesicular transport
References
Su et al., 2007: Su J, Yang J, Zhao D, Kawula TH, Banas JA, Zhang JR. Genome-wide identification of Francisella tularensis virulence determinants. Infection and immunity. 2007; 75(6); 3089-3101. [PubMed: 17420240].