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groEL

Victor ID 4569
Gene Name groEL
Sequence Strain (Species/Organism) Bartonella bacilliformis KC583
NCBI Gene ID 4683978
NCBI Protein GI 121602875
Locus Tag BARBAKC583_1172
Genbank Accession CP000524
Protein Accession YP_989430
Taxonomy ID 35685
Gene Starting Position 1211788
Gene Ending Position 1213422
Gene Strand (Orientation) -
Protein Name chaperonin GroEL
Protein pI 4.98
Protein Weight 51965.26
Protein Length 544
Protein Note 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
DNA Sequence 
>gi|121601635:1211788-1213422 Bartonella bacilliformis KC583, complete genome
CTTAGAAATCCATTCCGCCCATTCCGCCACCTGGCATTGCAGGCGCTGCTGCTTCTTTCTTCGGAACTTC
AGCAACCATCGCTTCTGTCGTGATCAAAAGACTTGCGATTGATGCTGCATTTTGCAGAGCAGAACGCACA
ACCTTCACTGGATCAACGATCCCAAAAGAAATCAAATCACCGAATTGAGCCGTTGCTGTATTGTAACCAA
ATGTATCTGAACAATTTTCAAGCACTTTGCCAACAATAACCGCTGCTTCTTCACCTGCATTATGAGCAAT
CTGACGTGCTGGAGCTTGCAAAGCACGGCGGATGATACCAATACCTGCTTCTTGATCTGGGTTTTTCCCT
TTAATAGAAAGAGCCTTTGCAGCACGCAAGAGCGCAGTTCCACCACCAGGAACAATCCCTTCCTCTACAG
CAGCACGTGTTGCGTTCAACGCGTCATCAACACGGTCTTTCTTTTCTTTCACTTCAACTTCTGTTGAACC
ACCAACACGGATAACGGCAACACCACCAGCAAGTTTTGCAAGTCTTTCTTGCAATTTCTCACGGTCATAG
TCAGAAGTTGTTTCTTCAATCTGTGCCTTAATCTGGCTAACACGTGCATTGATTTCAGACTTTTGTCCAG
CACCATCAACAATGGTTGTGGTTTCTTTAGAAACATGCACTTTTTTAGCGCGTCCAAGCATTTCTAAAGT
TACATTTTCAAGCTTAATACCGACATCTTCAGAAATCACCTGACCAGAAGTCAAAACTGCAATATCTTCC
AACATAGCTTTACGGCGGTCACCAAAACCTGGAGCTTTAACAGCAGCAATTTTTAAACCACCACGCAACT
TGTTTACAACGAGCGTTGCCAAAGCTTCACCTTCTACATCTTCAGCGATAATGAGAAGAGGCTTACCAGA
CTGAACAACAGCTTCAAGCACAGGCAACAAAGATTGCAGATTAGACAATTTCTTTTCATGAATAAGGATG
TAAGGATCATCAAGATCAACCATCATTTTTTCAGAATTGGTGACAAAGTAAGGAGAAAGATACCCACGAT
CAAACTGCATTCCTTCAACAACTTCCAACTCAGTTTCAGCTGTTTTTGCTTCTTCTACCGTGATAACACC
TTCATTACCGACTTTTTCCATAGCATCAGCAATCATTTTACCGATGTCCTCAGCGCCATTAGCAGAAATA
GTTGCAACTTGTGCAATTTCTTCTGAGGTTTGGATCTTCTTCGCTTTTTTGAAAAGATCTGCAACAACCG
CTTCAACAGCAGCATCAATTCCGCGCTTAAGATCCATTGGATTCATACTGGCTGCAACAGCTTTCACACC
TTCCTGAACGATGGCCTGCCCTAAAACAGTTGCTGTTGTCGTTCCATCACCAGCAATATCGTTGGTTTTT
GAGGCAACTTCACGCAACATTTGCGCGCCCATATTTTCAAACTTGTTTTCAAGTTCGATTTCTTTTGCAA
CGGACACACCATCTTTTGTAATGCGTGGAGCACCAAATGATTTATCAATCACCACATTGCGGCCTTTAGG
ACCAAGTGTTACCTTAACAGCATCAGCAAGGATATCCACACCACGTAACAACCTTTCACGTGCGTCACGG
CCAAATTTTACTTCTTTAGCAGCCA
Protein Sequence 
>gi|121602875|ref|YP_989430.1| chaperonin GroEL [Bartonella bacilliformis KC583]
MAAKEVKFGRDARERLLRGVDILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELENKFENMG
AQMLREVASKTNDIAGDGTTTATVLGQAIVQEGVKAVAASMNPMDLKRGIDAAVEAVVADLFKKAKKIQT
SEEIAQVATISANGAEDIGKMIADAMEKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNSEK
MMVDLDDPYILIHEKKLSNLQSLLPVLEAVVQSGKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPG
FGDRRKAMLEDIAVLTSGQVISEDVGIKLENVTLEMLGRAKKVHVSKETTTIVDGAGQKSEINARVSQIK
AQIEETTSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRVDDALNATRAAVEEGIVPGGGTALL
RAAKALSIKGKNPDQEAGIGIIRRALQAPARQIAHNAGEEAAVIVGKVLENCSDTFGYNTATAQFGDLIS
FGIVDPVKVVRSALQNAASIASLLITTEAMVAEVPKKEAAAPAMPGGGMGGMDF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: LSS100, a strain that synthesizes markedly greater quantities of GroEL relative to others, significantly accelerates apoptosis of the cocultured HUVECs relative to other strains (Smitherman and Minnick, 2005).
References
Smitherman and Minnick, 2005: Smitherman LS, Minnick MF. Bartonella bacilliformis GroEL: effect on growth of human vascular endothelial cells in infected cocultures. Annals of the New York Academy of Sciences. 2005; 1063; 286-298. [PubMed: 16481529].