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zafA

Victor ID 4566
Gene Name zafA
Sequence Strain (Species/Organism) Aspergillus fumigatus Af293
NCBI Gene ID 3510549
NCBI Protein GI 70995221
Locus Tag AFUA_1G10080
Genbank Accession AAHF01000004
Protein Accession XP_752374
Taxonomy ID 330879
Chromosome No 1
Gene Starting Position 2602908
Gene Ending Position 2604885
Gene Strand (Orientation) +
Protein pI 6.76
Protein Weight 60488.58
Protein Length 570
DNA Sequence 
>gi|71025128:2602908-2604885 Aspergillus fumigatus Af293 chromosome 1, whole genome shotgun sequence
CATGTCTTCCCACACCAAGAAAGATGATTTCTGCCTCGAATGTCACTGGGAGGCCTTTCATCTAGATGGT
AAGGACTCCCAGGACGGCGCGGAGGCCTCCGCTCAACCGCCAGAATGGAGTTGTCTGGACGAGGACCATC
ATCACACCTCGCTGGCGCATTGTGCTACAATTGACGAGGCGTGCTGTGATGTGGATGACTGTTCCGTTAA
CTGTCCTTCCGTCTGTGACGGCTTCAGAGAATGTGATGAGGCAACTGCTTGTTCTTTATCGCACTGTGAC
GACAAGGATTGCAAAAGCACGGACGCAGTCTGCTTCGATGAACACTGCTTTAGCTTTGCCGACCATAACG
GACAAGCCGCCGATCATAACAATCTAGACTCAATGCTGGGACTGGCGCAGCCACTGTCACTGGAAGCCTG
CGGCCTACTTCCGTCGTCGACCATCGATCAGAATCAAATGCAAGTGCCATCCAAGCCTACAGAGAATGCC
ACATCGGGCCTTGTCAACACATCACAGTCTGCGGACGCCCTGTTTCCTTTTCCAACAACGTTTCATCATT
GTCATCCTTCATATCCCCACTTCCACTGCCATCCTCTGCCCGGAGATTCACACAATCACCTTGGGAATGT
GCCATTTCCCCTGCCGAATAATTGCAATCCAGCAGATATCTTCCAGATGCTTGGAATGTGCTCCGGCGTG
TCTGCCTGTCCTGAACCCCACACCCACGAGGACCAGAACTGCCACATTCATCTAAGCAAACTGGACACCC
GGTCGACCGACTCGTTCACGTGCTTTCGCCTACCGCCCACTCCTAACGATTCGTCCAAAGCGTCAGTCAA
TATCCATGGGAATGTGCCGCTCAAAGGACCCTGCCGGTCGCATCATCGGTGTCGAATTCACCCCCACGCA
CATGTTCACCCGTACGGACCCTACTCCGCCTATTCCCGCCAGTCCCGATCGAGCGTGAGTTCACAACTGA
TGTCCAGTCCGGGCGAGACGCCCCCACCGTTGGAGGGTGGTGCCTCGTCCGTATTGACCAGTCCGGGGTT
CTCTTCCGCTGAAGGGGAAGTCCATGTTTGCAAATGGACGACCACGAGCCATGGTGTCAAGAGATCCTGT
GGAGCGACCTTTGCTGATGCTTGTGCGCTCCAGGAGCATCTGGTTGCCAACCATATGGGGACTGTGGAAG
GGGCAAAGGGTACCGGCTACTATTGCTGTTGGGAAGGATGCCATCGCCCTGATGAGCCTTTTTCTCAAAA
GTCGAAACTCCAGGGACATTTCTTGACGCACAGTAACTGTGAGTCCATAGAGTCTGTGAGAATGGAGCCG
AAAACTGACAGTCCTCATAGATAAAAACTTCAAATGTTCGGTTTGTGGCAAGCTGTTTGCTCGGCAAGCG
ACGTTGGAGCGACACGAACGAAGTCATCGAGGCGAGAAGCCGTACAAGTGTACCGAATGTGGCAAGTCAT
TTACCGACAGCAGTGAATTAAGTGAGTTACCTGACAGGTGTGTCCTTTGGTAGGATGCTGACTCGATAGA
AACGCATTCACGGACGCACACGGGCGAGAAGCCGTTCAAATGCACGTTTCCCGGATGCAACTTTCAGACA
GGCGATGTAAGTCGCGTCCTTGGGGGAATGGCATGTAAGCCTGTACTAACGAGAATATCTAACAGTCGTC
CAACATGTCAAGTCATCGACTAAGTATGTTCCTCGCCTATGGGAAGTAGTGCATGACTAACGAATGTAGC
TCACGGAGAACGAAAACACAAATGCAGTTATCCTGGATGCAGCAAAAGCTTTACTCGGCCTGGTACGTTG
CCCTACTTGACCCGCGGCAGAGTTGACAGGCCAGTACTGACTCCGACTGTAGACCAATTGAAACGGCATA
TGCGCACGACACACAAAGCAGACAGCACAGCCTTCCCATCACCGTCACCGCTCTCCGACCACTTTGCATT
CCCCCTTGGCACTGTTTG
Protein Sequence 
>gi|70995221|ref|XP_752374.1| C2H2 transcription factor [Aspergillus fumigatus Af293]
MSSHTKKDDFCLECHWEAFHLDGKDSQDGAEASAQPPEWSCLDEDHHHTSLAHCATIDEACCDVDDCSVN
CPSVCDGFRECDEATACSLSHCDDKDCKSTDAVCFDEHCFSFADHNGQAADHNNLDSMLGLAQPLSLEAC
GLLPSSTIDQNQMQVPSKPTENATSGLVNTSQSADALFPFPTTFHHCHPSYPHFHCHPLPGDSHNHLGNV
PFPLPNNCNPADIFQMLGMCSGVSACPEPHTHEDQNCHIHLSKLDTRSTDSFTCFRLPPTPNDSSKASVN
IHGNVPLKGPCRSHHRCRIHPHAHVHPYGPYSAYSRQSRSSVSSQLMSSPGETPPPLEGGASSVLTSPGF
SSAEGEVHVCKWTTTSHGVKRSCGATFADACALQEHLVANHMGTVEGAKGTGYYCCWEGCHRPDEPFSQK
SKLQGHFLTHSNYKNFKCSVCGKLFARQATLERHERSHRGEKPYKCTECGKSFTDSSELKTHSRTHTGEK
PFKCTFPGCNFQTGDSSNMSSHRLTHGERKHKCSYPGCSKSFTRPDQLKRHMRTTHKADSTAFPSPSPLS
DHFAFPLGTV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: zafA mutant is attenuated in a murine model of invasive aspergillosis (Moreno et al., 2007).
References
Moreno et al., 2007: Moreno MA, Ibrahim-Granet O, Vicentefranqueira R, Amich J, Ave P, Leal F, Latgé JP, Calera JA. The regulation of zinc homeostasis by the ZafA transcriptional activator is essential for Aspergillus fumigatus virulence. Molecular microbiology. 2007; 64(5); 1182-1197. [PubMed: 17542914].