Victors

sidD
Victor ID	4565
Gene Name	sidD
Sequence Strain (Species/Organism)	Aspergillus fumigatus Af293
NCBI Gene ID	3506154
NCBI Protein GI	70986336
Locus Tag	AFUA_3G03420
Genbank Accession	AAHF01000010
Protein Accession	XP_748662
Taxonomy ID	330879
Chromosome No	3
Gene Starting Position	908167
Gene Ending Position	914473
Gene Strand (Orientation)	+
Protein pI	4.78
Protein Weight	211983.17
Protein Length	2083
DNA Sequence	>gi\|71025130:908167-914473 Aspergillus fumigatus Af293 chromosome 3, whole genome shotgun sequence AATGGGTTCAATACAGCAAGATGACGTTCACAATCAGATAGACCACTGCAATCAGTCAGATGACTTACCG GCGGCCCGGTTGAATTGCAATGACGTCGAATTATTCGAGGTGGCTGGCCTCGCATGCGACGAGACCTCGA GTCCCACAGGCATGAGAGACGAAATGGTACTTTTATCGTGGCTCATTGCGCTCCTGCGGACACGAGAAGG CGGCCAGATTCGGTACGAATGGGCATATAGGTATCCAGAAGAGGAGCCGGTACCTAGATGTCTGGCTATG AATGAAGTAGTGGCGGGGTTACAAAGTAGTGTCAAGGAAACTGCAGCAGCTGTGTCTCGGCATATTTCCG CAGATGTATCGAGTCCGCCGGCGCCAGCATCTCTGCTTCTGAGCACTAGCTCCCTTTCTCAGACATCAGA CGAAGCAAAAGATGAAGTAAGTCAATGCGTGGGTTTTGAAGACGTGAGCCTAGCTGACTGCGGGAACAAA GGGGTTACTTCACCTAGAAATCGCTTTCGAGAATGGGCTGTGCAAGATTCGTCCGACATGGCACTCCGAG AATATGTTGCCGTTTACAGTGACGCGATACGCCAGGACCCTCATCGACACGGTTAGGCTGTGCATTTCCA ATTGCGATGCCGCCATCCAAGACTGCCTTCGGCCTACCGCATACGATCTCGACGAGATATGGCGCTGGAA CCACAACCTGCCTCCCACGTACAATTTCTGCATGCACGAAATAATCTCCGACCAGGCTCAGAAGTTCCCC GACAAGGAAGCAATCGCATCCTGGGACGGCAGCCTGACTTACAGACAGATTGATCAGTATTCATCATTCG TCGCGCGCTCACTTATAGGCATGGGAGTTGGGCTGCATGATGTCTTACCAGTCTGCTTTGAGAAATCCCG ATGGACGATTGTCGCGGTTCTGGCCGTAATGAAAGCTGGCGCGACGTTTGTACTAATGGACCCGACGCTT CCACTTGCACGATTGCAGAACATGGCCCAGCAGGTCGGCGCGAAGATGATGGTTTCATCTCGGGGCCAGT ACAACCTGGCGACGGAGATCATACCCAATGCAAACGTGCTCGTCGTGGAGGAAAACACGTTCAGCAGTCT GTCCGCCGAACAGAACGGCGAGCCCCTGCCAACGGTTCCCTCCTCGGCCCTGATGTACATGATCTTTACA TCCGGCAGCACAGGTACTCCGAAAGGAGTCAAAATCTCCCACGAAACCTACACCAGTAGCGCCATTCCCC GGGCCAATGCGGTAGGTTACACGGAGGATTCCCGCGTTCTCGACTTCGCCTCCTACGCCTTCGACGTCAG CATCGACAGTATGCTGCTGACCCTGGGCAACGGCGGCTGTCTGTGCATTCCGTCCGACGAAGACCGCCTG AACGACATCAATGGCGTGATACGGCGAATGAAAGTCAACTATGCGGGCCTGACGCCTTCGGTAGCCCGTA TTCTAGACGCAGATGTAATATCCTCGCTCAGTGGTCTTGGCCTCGGAGGAGAGGCCGTCTCAGCGAGAGA TGTCAATCTCTGGGGTCAGGACACCAGGATTATTATCGGCTACGGGCCCTGCGAATGCACGATTGGATGC ACAGTGAATAGTAGCGCGGCAACGGGAAGAGACTATATCTCCATTGGCCCTGGTAATGGGGCAGTAATCT GGATAGTCGATCCTAACGACCATGAATCTCTCGTGCCTCTCGGCGCGGTAGGAGAGCTGCTGGTAGAAGG TCCCATAGTAGGGCAGGGCTACTTGAATGATCCGGAGAAAACTGCAGCAGCGTTCATTGAAGACCCCTCA TGGTTGGTTGCGGGCCACGAAGGTTACCCCGGTCGTCGGGGCCGTTTGTACAAGACCGGTGATCTCGGTC GATATGACCCAGATGGGTCAGGCGGTATCGTGTTCGTGGGGCGCAAGGATACCCAGGTTAAATTGCGAGG ACAACGGGTAGAGCTCGGGGAGATCGAAAGCCAATTGAGAGCCAGACTGCCCTCGGAGACGACTGTGATC GCCGAGGTGATTGTACCCCAAGGATCTGGGGGACAACCGACGCTGGTGGCATTTGTTGCTGCCCAGACGA CCAAGGGACATGATCATACCGGACTCGAGGCGGCAGAGCTTCCCGATGAGCTTCGAAGGGCGCTGTCAGA AGCCGATGCGGAGCTGGCAAAGGTATTGCCTCGATACATGGTGCCAACAGCGTATATTCCTGTCAACCAC ATCCCTACGCTGATTTCAGGCAAAACAGACCGCAAGAGACTGAGGCAGTTCGGCGCAACCGTTGACCTGC GCCAGCTGGACCAGGATGCTACGAACACCGCAGCTCGGGAGCTGAGTGATCTGGAGCGTCGCTTGCGACA GGCATGGAGCCAGACGTTGAAGCTCCAAGCGTGTTCTATTCGTCTACAGGACAACTTCTTCGCTCTTGGT GGAGACTCCCTCACAGCCATGAAGCTGGTCTCTGTATGTCGGTCCCAGGGTCTCGACCTCAGTGTCACCA GCATGTTTAGCAATCCTACCCTGTCAGCCATGGCCAGCGTTGTCCGTATTTGCGACGTCGACGTGCAAAG GACAGTCCCGGCATTCTCGATGATCACATCAGATATGAACAGTGCCTGTGTAGAGGCAGCAGAGCCCTGC GGAGTTGGCCCAGCAGATATCGAGGACATCTACCCCTGTACGCCAACACAGGAGTCTCTTTTCACTTTCT CGCTCAAGTCAGTCAAGCCCTACGTGGCACAGAGAGTCCTATGTATCCCGTCTCATATCGACCTCAACGC ATGGAGGAAGGCATGGGAGGATGTGGTCGCCGCACTCCCCATCCTACGGACACGAGTAGCTCAGCTGCAA GAGCCTGGCCTTCAGCAAGTTGTACTCAAGAACAGCATTTCCTGGACGCAAGCCTCAGATCTAGCGGAAT ACCTAGAGAACGACCGAACCCAAAAGATGAATCTCGGAGAGAGTCTGGCCCGTTACGCCATCGTCGAAGA CTCAGCCGACGGCAAGCGATACATGGTTTGGACTATTCACCATGTGTTGTACGATGGGTGGTCAGAGCCG ATTATCCTCAAGCAAGTCAGCGACGCCCTGCAAGGGCAGCCAGTCGAGGTAAAGGCGCAGATGCGAGACT TTGTCAGATTCGTGCGAGACTCGGATGACGCTGCAGTGCAGGAATTCTGGCGGCGCGAGCTGAAAGGTGC CGTCGGGCCCCAATTCCCACGTCTACCCTCAAGAGACTTCATGCCTACCCCGGACGCCCTAGTCGAGCGT CAAGTCTCTCTTGATACTAGCTCCGGATCACCGTTTACCATGGCGACATTGATTCGCGGCGCCTGGGCGC TCGTCGCGTCCCAATATACTGGAAGCGACGATATCGTGTTCGGCGAGACCCTCACAGGTCGCGACATCCC ACTACCTGGAGTCGAAAGCATTGTTGGACCATTAATTGCGACGGTCCCCATCCGCGTGCGCATTCTCCGG GGAAGTACTGTGGAGTCCTACCTCCAAGCCGTGCAGCAGAGTGTTTTGGCCCGTACCCCGTACCAGCATT TGGGTATGCAGAACATCCGCAAGGTTAGCCAAGATGCGCAACACGCGTGCGAGACTGGTACGGGTCTGGT CATTCAGCCTGAACCAGAGTATGTCGGCAGCGAACTGGGCGTTGAGAGAGGGGACGTGGTTCTTGAAGCG CTGCATTTCAACCCGTATCCGCTGATGCTGGCTTGCGGGATTCGCAAGGGTGGTTTCCGGGTTTGTGCAA GCTTTGACAGCAGCTTGATTGAGACCAGGCAGATGGAACGAATGCTTGCCCAGCTTGAGACCGCGTGCTG GCAGTTGAGTCAAGGTCTTTCCCGGAAGGTCGATGAGATCTCGTGTCTCCCCGAAGCCGAGTTGAACCAG ATCTGGCAGTGGAATCGGAGTCCACCTTTGTCTCTGGACGAAACAACCAGTCGGTTGCGTGCGAATGCAA GCACAAAGCCTGGTTCAAGCTATCCTCCCGCGGTTGTTCCTTGGGTTTGTAGTCCACGAAACTCATCTCT CCTCTCGCCAATCGGCTGTGTTGGCGAGCTCTGGCTTGAAGGGGCCCTTCTTTCGGGCGACACAGTTGAT TCACCTGCCTGGCTTGTGGCTGGAAGCTCTACCTGTGCTGGCCGAACTGGCAAAGTGCAAGCAACCGGCG ACATGGTTCAGTTGCGAGAAGACGGCAGTTTAGTGTTTGTTGGTCGGAAGGAGAATGTTGTTCCTGTTCA AGGGCATGCAGTGGACATCACAGAGATTGAAAGGCACCTCGCAGAACATCTGCCGCCAACAATCCGTGCC GCTGCTACTGTAGTGCGGTCTTCATCCGACCAGGAGCTGGTTATGTTCATTGAGCAACCGGCTGCGGAGG AAGCCTGTATTGAGCTCCTATCGGAGAAGCGCGAAATAGTGTGCGACGCGCCAGACAAAGCCTTCCAGAC CACAATTTGTGCGACAATCCCGGGCAGTCTTGCTGCAGTGTTGAAGAAGTTGGACAAATACATGCGAGAC TCGCTTCCGTCATATATGGCTCCGTCCGCTTACATCGTGGTAGAGAAACTGCCTAATACGATGGACGATA TCGACCACAATTTGCTCAATCAGATCGCCTCTCAGGTCACTCCACAAATTCTCAACGAGCTTCGCGATGG GTTGAGCAACGCTTGGACCAAGGCTACGGCTCCAAACCATCTATCAGCTTCAGAAAGCATTCTGCGGTCT GCATGGGCCAAAGTGCTTCGTGTCGATCCGGAGCAGATCGACGTGGACGACAATTTCTTCCGGCGCGGTG GTGATTCCGTACTTGCAATGAAGCTTGTGTCGAGTCTCCGAGCGCAAGGCTACAGTTTGTCCGTGGCTGA TATCTTCCGGCACATGCGTCTCAGCGACGCTGCCAGAGTGATGAAGGTGGATGAACGCTCAACAGAGAAG ATCAACTCATATCAGCCGTTTTCGATGCTCCGTCTCCCAGACGTTCAGCAGTTCCTTGCCAACATTGTCC GACCACAGCTAGGGGACCAACACTGGCCCATTCGAGACGTGTTGCCGGTGACCGACTCCCAGGATATGGA TATCCGTGCAACCATTCAGCCGCCGAGGACGTCAATCCAGTATACAATGCTGTACTTTGACAACAGCGTT GACAGAGAGCGGCTTTTCCGTTCGTGCAGCGACCTGGTTAAGACGCACGAGATTCTCCGTACCGTCTTCA TATCACACGAATCCAGCTTCTTGCAGGTTGTCTTGAATGAGTTGGAAATTCCTGTCCGCGCACACAAGAC TGACAAGCAGCTCGATCAATACGTCGCCAGCCTCTTCAGGGAGGACATTGAATCCAACTTCCAGTTAGGA TGTCCATTCCTCCGACTTTTCTACGTCGAGGGAAACAACGGCGAATCCTGCCTCGTCATCGGCTTATCCC ACGCCCAATACGATGGCGTCTCCCTGCCCAGACTCCTCCAAGACCTCGACGCCCTATACACCGGCACCCA GCTCGCCACCTTCTCCCCATTCTCCTTGTACATGGCCCAGACCAGTGAAGAGGCAATTCAAAACAAGGCA GCGGCCTACTGGCGCAACCTCCTCTCCAGCTCCTCACTCTCGACCCTCGACGGACCCTCCTCTGATCCCA CCGACAAAGCAATCTTCCACACTCGCCCGGTCAACATCCATCCCCTCAAGGAGATCACCACCGCAAACCT CCTCACAGCAGCCTGGGCGATGGTCCTCGCTCGCCGTCTCCAAACCCCAGACGTCACCTTCGGCAGCGTC ACCTCCGGCCGCACCCTCGACATTCCCAACGCCGAAAACTTCATGGGCCCCTGCTACCAGCTCACCCCCG TCCGGGTCCCCTTCCATCCCGACTGGACCGCAAGCGACCTGCTGAACTTCGTCCAGACACAGTCTGCCGA GTCTGCGGCGCATGACTTCCTCGGTTTTGAGAAGATCGCTAAGCTCGCGGGGTGGGCCTCAGGAAGGCAA GGCTTTGATTCGATCGTGCATCATCAGGACTGGGAGGATTTCGATATGATGCCGTTTGGCGGAGGGTCTT GTCGGGTGGACATTGCGAATCCGCATGGGGATGCGGCGTATCCGGTCAAGGCTGTTTCGTTTGTGAAGGA GGGAGAGATACATGTTGGTGTGGTCTGTAGTGAGAGAGATGTGATGTTTGTAGACGAGGTTCTCGGGGAA TTGGCTGCTGCGGTTGTGGAGTTGGCTGGTCAGAGTACAGAGGTGTTGCTGGATAGCAAGTTGTTTAGTG GACAGTG
Protein Sequence	>gi\|70986336\|ref\|XP_748662.1\| nonribosomal peptide synthase SidD [Aspergillus fumigatus Af293] MGSIQQDDVHNQIDHCNQSDDLPAARLNCNDVELFEVAGLACDETSSPTGMRDEMVLLSWLIALLRTREG GQIRYEWAYRYPEEEPVPRCLAMNEVVAGLQSSVKETAAAVSRHISADVSSPPAPASLLLSTSSLSQTSD EAKDEGLLHLEIAFENGLCKIRPTWHSENMLPFTVTRYARTLIDTVRLCISNCDAAIQDCLRPTAYDLDE IWRWNHNLPPTYNFCMHEIISDQAQKFPDKEAIASWDGSLTYRQIDQYSSFVARSLIGMGVGLHDVLPVC FEKSRWTIVAVLAVMKAGATFVLMDPTLPLARLQNMAQQVGAKMMVSSRGQYNLATEIIPNANVLVVEEN TFSSLSAEQNGEPLPTVPSSALMYMIFTSGSTGTPKGVKISHETYTSSAIPRANAVGYTEDSRVLDFASY AFDVSIDSMLLTLGNGGCLCIPSDEDRLNDINGVIRRMKVNYAGLTPSVARILDADVISSLSGLGLGGEA VSARDVNLWGQDTRIIIGYGPCECTIGCTVNSSAATGRDYISIGPGNGAVIWIVDPNDHESLVPLGAVGE LLVEGPIVGQGYLNDPEKTAAAFIEDPSWLVAGHEGYPGRRGRLYKTGDLGRYDPDGSGGIVFVGRKDTQ VKLRGQRVELGEIESQLRARLPSETTVIAEVIVPQGSGGQPTLVAFVAAQTTKGHDHTGLEAAELPDELR RALSEADAELAKVLPRYMVPTAYIPVNHIPTLISGKTDRKRLRQFGATVDLRQLDQDATNTAARELSDLE RRLRQAWSQTLKLQACSIRLQDNFFALGGDSLTAMKLVSVCRSQGLDLSVTSMFSNPTLSAMASVVRICD VDVQRTVPAFSMITSDMNSACVEAAEPCGVGPADIEDIYPCTPTQESLFTFSLKSVKPYVAQRVLCIPSH IDLNAWRKAWEDVVAALPILRTRVAQLQEPGLQQVVLKNSISWTQASDLAEYLENDRTQKMNLGESLARY AIVEDSADGKRYMVWTIHHVLYDGWSEPIILKQVSDALQGQPVEVKAQMRDFVRFVRDSDDAAVQEFWRR ELKGAVGPQFPRLPSRDFMPTPDALVERQVSLDTSSGSPFTMATLIRGAWALVASQYTGSDDIVFGETLT GRDIPLPGVESIVGPLIATVPIRVRILRGSTVESYLQAVQQSVLARTPYQHLGMQNIRKVSQDAQHACET GTGLVIQPEPEYVGSELGVERGDVVLEALHFNPYPLMLACGIRKGGFRVCASFDSSLIETRQMERMLAQL ETACWQLSQGLSRKVDEISCLPEAELNQIWQWNRSPPLSLDETTSRLRANASTKPGSSYPPAVVPWVCSP RNSSLLSPIGCVGELWLEGALLSGDTVDSPAWLVAGSSTCAGRTGKVQATGDMVQLREDGSLVFVGRKEN VVPVQGHAVDITEIERHLAEHLPPTIRAAATVVRSSSDQELVMFIEQPAAEEACIELLSEKREIVCDAPD KAFQTTICATIPGSLAAVLKKLDKYMRDSLPSYMAPSAYIVVEKLPNTMDDIDHNLLNQIASQVTPQILN ELRDGLSNAWTKATAPNHLSASESILRSAWAKVLRVDPEQIDVDDNFFRRGGDSVLAMKLVSSLRAQGYS LSVADIFRHMRLSDAARVMKVDERSTEKINSYQPFSMLRLPDVQQFLANIVRPQLGDQHWPIRDVLPVTD SQDMDIRATIQPPRTSIQYTMLYFDNSVDRERLFRSCSDLVKTHEILRTVFISHESSFLQVVLNELEIPV RAHKTDKQLDQYVASLFREDIESNFQLGCPFLRLFYVEGNNGESCLVIGLSHAQYDGVSLPRLLQDLDAL YTGTQLATFSPFSLYMAQTSEEAIQNKAAAYWRNLLSSSSLSTLDGPSSDPTDKAIFHTRPVNIHPLKEI TTANLLTAAWAMVLARRLQTPDVTFGSVTSGRTLDIPNAENFMGPCYQLTPVRVPFHPDWTASDLLNFVQ TQSAESAAHDFLGFEKIAKLAGWASGRQGFDSIVHHQDWEDFDMMPFGGGSCRVDIANPHGDAAYPVKAV SFVKEGEIHVGVVCSERDVMFVDEVLGELAAAVVELAGQSTEVLLDSKLFSGQ
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: sidD mutant is attenuated in D. melanogaster (Chamilos et al., 2010).
References	*Chamilos et al., 2010:* Chamilos G, Bignell EM, Schrettl M, Lewis RE, Leventakos K, May GS, Haas H, Kontoyiannis DP. Exploring the concordance of Aspergillus fumigatus pathogenicity in mice and Toll-deficient flies. Medical mycology : official publication of the International Society for Human and Animal Mycology. 2010; 48(3); 506-510. [PubMed: 20370364].


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