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pksP

Victor ID 4559
Gene Name pksP
Sequence Strain (Species/Organism) Aspergillus fumigatus ATCC46645
NCBI Protein GI 3163925
Other Database IDs CDD:29420
CDD:129058
CDD:161724
CDD:186816
CDD:186876
CDD:144533
CDD:187168
GOA:O60026
InterPro: IPR000794
InterPro: IPR001031
InterPro: IPR001227
InterPro: IPR006162
InterPro: IPR006163
InterPro: IPR009081
UniProtKB/TrEMBL: O60026
Taxonomy ID 5085
Gene Strand (Orientation) ?
Protein Name polyketide synthase
Protein Length 2146
Protein Note polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; cd00833
Protein Sequence 
>gi|3163925|emb|CAA76740.1| polyketide synthase [Aspergillus fumigatus]
MEDLHRLYLFGDQTISCDEGVRNLLQAKNHTIVASFIERCFHALRQEITRLPPSQRTLFPRFTSIADLLA
QHRESGTNPALGSALTCIYQLGCFIDYHGDRGHPYPSSDDGLLGSCTGMLSCTAVSSCKNVGELLPLAVE
IVRLTIHLGLCVMRVREMVDSTESSSGSWSILVSEINEADATSLIGDFVKKRGIPPSSQPYISAVGSKGL
TISAPPEILDNFIEEGLPKEYKHFKAPGVSGPYHAPHLYNDREIRNILSFCSEDVILRHTPRVPLVSSNT
GKLVQVKSMRDLLKVALEEILLRKICWDKVTESCLSIVQATNDKPWRILPIASNATQGLVTALQRMGNCQ
IEVDTGVGAPQMDPAAPNATGNASRSKIAIIGMSGRFPEADGIEAFWDLLYKGLDVHKKVPPERWDVDAH
VDLTGTKRNTSKVPYGCWINEPGLFDARFFNMSPREALQADPAQRLALLSAYEALEMAGFVPNSSPSTQR
DRVGIFMGMTSDDYREINSGQDIDTYFIPGGNRAFTPGRINYYFKFSGPSVSVDTACSSSLAAIHLACNA
IWRNDCDTAISGGVNLLTNPDNHAGLDRGHFLSRTGNCNTFDDGADGYCRADGVGTIVLKRLEDAEADND
PILGVINAAYTNHSAEAVSITRPHVGAQAFIFNKFFNDTNTNPHEIGYVEMHGTGTQAGDAVEMQSVLDV
FAPDYRRGPANSLYLGSAKSNIGHGESASGVTSLVKVLLMLKQNMIPPHCGIKTKINHNFPTDLAQRNVH
IAFKPTPWNRPVSGKRKMFINNFSAAGGNTALLMEDAPLREITGQDPRNVHVVSVTARSQTALKRNINAL
IKYINTHAPSSPANERRFLASLAYTTTARRMHHPFRVTAVGSSVKDIREVLRQRADQDVTTPVPATAPKT
GFVFTGQGAQYTGMGKQLYEDCATFRSTIHRLDCIAQSQGFPSILPLIDGSMPVEELSPVVTQLGTTCLQ
MALVDYWKGLGVTPAFVLGHSLGDYAALNSAGVLSTSDTIYLCGRRAQLLTQQCQMGTHAMLAVKAAVSE
IQHLLDPDVHAVACINGPTETVISGLSGRIDELAQQCSSQNLKSTKLKVPFAFHSAQVDPILESFEESAQ
GVIFHEPAVPFVSALNGEVITESNYSVLGPTYMVKHCREAVNFLGALEATRHAKLMDDATLWVEVGSHPI
CSGMIKSTFGPQATTVPSLRRDDDPWKILSNSLSTLHLAGVELNWKEFHQDFSSAHEVLELPRYGWDLKN
YWIPYTNNFCLTKGGPVTAEVSAPKSTFLTTAAQKIVECREDGNTATLVVENNIAEPELNRVIQGHKVNG
VALTPSSLYADIAQTLVDHLITKYKPEYQGLGLDVCDMTVPKPLIAKSGDQFFRVSAVMSWAEQKASVQV
WSVNGDGKKMAEHAHCTVKLFNCAERETEWKRNSYLIKRSVSLLQDKAQTGEAHRMQRGMVYKLFAALVD
YDENFKAIQEVILDSNEHEATARVKFQAPPGNFHRNPFWIDSFGHLSGFIMNASDATDSKNQVFVNHGWD
SMRCLKKFSGDATYQTYVKMQPWKDSIWAGDVYVFEGDDIIAVYGGVKFQALARKILDTVLPPIGGFKTV
GAPAPAPARPIGEKKAPPPIKVTGPPKPNPSNARAASPVVARALEILAAEVGLSEAEMTDSLNFADYGVD
SLLSLTVTGRYREELNLDLESSVFMDYPTIKDFKAYLAEKGFCDSSSPEPSSEPESKFSFNSDASSEASS
GLTTPGITSPVKHEAPKGGQNKVWKSICSIIAEEIGVSVGDIDPSDNLPEMGMDSLLSLTVLGRIRETLG
MDLPAEFFLENPTLDAVQAALDLKPKMVPAATPVSEPIRLLETIDNTKPKTSRHPPATSILLQGNPHTAT
KKLFMFPDGSGSASSYATIPALSPDVCVYGLNCPYMKTPQNLTCSLDELTEPYLAEIRRRQPKGPYSFGG
WSAGGICAFDAARQLILEEGEEVERLLLLDSPFPIGLEKLPPRLYKFFNSIGLFGDGKRAPPDWLLPHFL
AFIDSLDAYKAVPLPFNDSKWAKKMPKTYLIWAKDGVCGKPGDPRPEPAEDGSEDPREMQWLLNDRTDLG
PNKWDTLVGPQNIGGIHVMEDANHFTMTTGQKAKELSQFMATAMSS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pksP mutant is attenuated in mice (Langfelder et al., 1998).
References
Langfelder et al., 1998: Langfelder K, Jahn B, Gehringer H, Schmidt A, Wanner G, Brakhage AA. Identification of a polyketide synthase gene (pksP) of Aspergillus fumigatus involved in conidial pigment biosynthesis and virulence. Medical microbiology and immunology. 1998; 187(2); 79-89. [PubMed: 9832321].