Victors

pkaR
Victor ID	4558
Gene Name	pkaR
Sequence Strain (Species/Organism)	Aspergillus fumigatus
NCBI Nucleotide GI	15825179
NCBI Protein GI	15825180
Protein Accession	AAL09588.1
Taxonomy ID	5085
Gene Strand (Orientation)	?
Protein Name	cAMP-dependent protein kinase regulatory subunit PKAR
Protein Note	isolated from endothelial cells
DNA Sequence	>gi\|15825179\|gb\|AF401202.1\| Aspergillus fumigatus cAMP-dependent protein kinase regulatory subunit PKAR (pkaR) gene, complete cds TATTTTCTCATGCCTCTTTCCCCTCCTCCTCCCTCCTACTACTACCCCTGCCCCTATCTGCTTGGACGGT CTCACCTCGGCTACCGGGAGTCGTCTCTCTCTGAATCCTTGTGTCGGCTTACTCAGAGTCATCATACGTC CATCTTCTTCACGAGACCCATCAATATAAGAGACAGAGTTTAGGTCGGTAGCTCCATTCCATTTTTCTCA AGCTTCAACCTTCCCTTTTCCAGTGTCGTACTTGCTGTTTATCATTCTTGTCCAATACTTCCTGTTTCAA ATTGTGCACGCACTTGTTTCCTCTCACTGAAACACAAAAAATTGCAATGAGCGTTCTGCTACGTCATTAC TCAAAGAGAGGGGTTATAGAAGGAGCATACGATCATCTTCGGATTGGTGCGTTCTTAAACTCTCCAATTA GGTTCACTTGAGATACCCACCAGTCTTCAGCGGGGACGGTTGCTGTGTGTGCTTTCAACTCCGCCCCTCC TCACCACTATCTTCTGCTGTTCAACTTCGACATCTCTCCTCCATTGAAGAACTTCATCTACTATCTTCCC AACTGGACCTCAAGTTCTGTCTTCGTTGCTTTCTAACTCCTACAGACCACTTTCGTCTCTGTCCTTCCAC CAGCTCTGCCCGCTTACAGCCAACAGGATGGCTGATAGCTCTTCTTTCCCGGGTACAAACCCGTTCCTTA AGGTCAGCACGAAAGACGACAAATATTCCCCGATCCAGAAGATATCCGAGGAGGAAGAATATGAGGTGAC GTCACCGACCGATCCCACTTTCCGCAGCGCACACTCCGGGGCTACAGCACCCACTGCTGGAAACTCGTTC AATGGAGACAATGGCTCCAACGAAGGTGGTGAGGGAATACAGTTCAATAGGCCCTTTGATGCAGGATTTG GTCAGGGGAGCGAAGGTCAAGGCGAACACGTCGAGCCTCCCGGAGGAGCTCGCCCAACGGCAGCCGCCAA CCAAGGGTTCCCTAACAACTATGCTCTCGGCCGTCGTACCTCTGTATCCGCCGAGTCCCTGAACCCTACC TCTGCTGGCTCAGATAGCTGGACGCCCCCATGTCATCCGAAGACCGAAGAACAGCTTTCGCGTTTGAAAA CGGCTGTGAGCAACAATTTCTTGTTTTCTCACCTGGACGACGACCAATTCAGGACTGTACTTGACGCTTT GGTTGAAAAACCCATTCCTGCGAAAGATATCAAGGTGATTTCGCAGGGAGATGCCGGTGATTACTTTTAC ATAGTGGAGAATGGCCATTTCGATGTCTACATCAACCCCGCGGGCTCAGTCCAACCAGGCCCCGATGGTA TTGGCAACAAGGTCAGCACCATTGGTCCTGGAGGCTCCTTTGGTGAACTAGCCTTGATGTACAACGCGCC CCGAGCCGCGACTATTGTCTCAGCAGACCCCAAGAGCACGCTTTGGGCTTTGGACCGCATCACTTTCCGC CGGATTCTCATGGACTCTGCCTTCCAGCGACGCCGCATGTATGAGGCTTTCTTGGAAGAGGTGCCATTAC TTTCTTCTCTCAAACCATATGAACGCGCCAAGATTGCCGATGCTCTCGATGCGATTAAATACCCAGCGGG CTCTACAATCATCGAGGAGGGCGCTCCAGGCGATGCTTTCTATCTACTTGAGTCTGGGGAGGCGGAAGCT TTCAAAAAGGACGTGGAGGGCCCCGTCAAGTCGTATAGGAGGGGCGACTTTTTCGGAGAGCTCGCCTTGC TGGACGACAAACCTCGTGCTGCTAGCGTGGTCGCCAAGACCGACGTCAAAGTTGCACGACTTGGTCGCGA TGGGTTCAAACGGTTACTGGGGCCTGTGGAGGATATTATGAGAAGGGCTGAATACTCCGCGAAGCCTTCG CCCTCGTGATGCGTTCGATAGACTGGGATAAAGTGGTTGACGTGGAGACATGCTTGGTCATCATCATTTT TAGTTCTTATTCTTGTACCTCGTTTATCGTTCTTTCTTGGGCTCAACGGACACGGTAAAGGCAAGTTTGG TCTTGGGAATATGAAGCGATGAACATGACAGCCTCTCCGATGGATCATTCGGGTTTCACTGTCTCGTTAC CGACATAGTAGATTGTCTTTCAAGTGTTGGGATCACACTGAGGACTAAGTTTTAAAACGTTTCATTTGTG CGACTTTGATGCTCGTGTGAGCCGAAACCGGGTTTGTCCTTGTCTCTTTCCAGCATCAATTCTTCTGTTC TCTCTTATGGGGGTAAAACGTGGCAAACGTCCCTGTCATCATTACATCTCACTGGCTGCTATTCCAAATT ATTTCTCTGGGGTTGTCTGACCAACATTGGAAGATTGCGGTGTGCAAACATCCTGTATTGTGACTATGGT TTCTTCCTGTGCAAATATACACCGAATGCTGTTGACGAGCCAGTCCTATTCTGCTTAGTTTCTGAACATA TATGTAACATGAAACATTCTGCTTGTTCAACCATCAGTCGAAGCATTAGTCCGAGTCCAGAGGCTTTTAT CTCACGCCAATAAGCAACTCTATATAGGCACAACAGCCTCTGGCACTTGAAACCCGGTCTACAACAGGTG AAACGTAGGCAAAAGTCCACTCACGTCCATCACCGTGCAACCACTAAATCACTTCTTAAAACCCACTTCT CGCCCTCGGTGACCTCCCTACCCTCATGCAAAAGACACCTTTCCCCATGCCGATGCAGCAGCGCCATCCC CACCTCCGGCGCCACCGCAATAGGCTCCGGGTTGCGATTCGCGCCGGTGGGCTCAGGGTAAAAAACTGTC TCCCCTCCCGTACAGTTCGTCAAGTAAACCAGGAGGTCCAGGTTGTTCGACCCTGCTGCAGCTTATGTTG AGGAGACTCGAACGCAACCACATTCGAGTCATCGTCTAGCAATTCACTCAGCCCATCTCATCCCAAAAAA GAGGAAGGACAAAGAGAGGGGGGGGGGGGGGGACATACAGTGCTGGGCGAAAAACTGGCCTCTTGAATAC CGATATACCCTGATATTTGCATTTAGACCAAGCGGCTCCCCGCCCCAAATCTCCCTGTTTGAGCGTGGCT GCCCGTCGCCATCCTGGTCCTCGTCAACAGCACCGCTCACCAGCTCCCTCAGCGCCGTCCCGCTCCACAG CCTCTCGGCGAAAATCGGCATCCTGTATCTGGAACCGGTCATTGACACGGACGGCCTCGCCCTTTTTGGG TTTGCTGGGAGTGGTGGTGAGTGGGAGCGACGCTAGGAAGAAGGCGTAGGTTTTGC
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: pkaR mutant is attenuated in an immunosuppressed mouse model (Zhao et al., 2006).
References	*Zhao et al., 2006:* Zhao W, Panepinto JC, Fortwendel JR, Fox L, Oliver BG, Askew DS, Rhodes JC. Deletion of the regulatory subunit of protein kinase A in Aspergillus fumigatus alters morphology, sensitivity to oxidative damage, and virulence. Infection and immunity. 2006; 74(8); 4865-4874. [PubMed: 16861675].


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pkaR