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pkaC1

Victor ID 4557
Gene Name pkaC1
Sequence Strain (Species/Organism) Aspergillus fumigatus Af293
NCBI Gene ID 3513486
NCBI Protein GI 71001742
Locus Tag AFUA_2G12200
Genbank Accession AAHF01000001
Protein Accession XP_755552
Taxonomy ID 330879
Chromosome No 2
Gene Starting Position 3141792
Gene Ending Position 3143442
Gene Strand (Orientation) -
Protein pI 8.06
Protein Weight 53414.67
Protein Length 490
DNA Sequence 
>gi|71025129:3141792-3143442 Aspergillus fumigatus Af293 chromosome 2, whole genome shotgun sequence
ACTAGAAGTCTGGGAAAAGATGGCCATGCCTGTAGCAAGAGTTTCGGTTAGTACTCTGATCGAGAATGAT
TCGCAACTGGAACACATACACATCTTCGCCCTGCTGACCGTATTGTTCAGTCTCCTCGGGATACCGATCG
TATTGGCTGGCATCACCCTGACCTCCACGGATAGGAGGAACATAAGGAGCATCAATGTCCTTTCTTGCAA
GACGATCCCAGGTGACTTCCGCAAACCAAGGGTGGTTCTTCACATCTTCGGAACCTCCATGAAGGTTGCC
CAGTCGCTTTGTCAAATCCGCTGTGATGAGCTGCGAGAGCAAGTCGACGGCGTCTGGGTGAAGATAGGGC
GGGTACTTGACACGGCCGCGGAGAATGTTCTCGTAGATCTTGACGGGCGAGCCACTGTCCCAGAAGGGTG
TGAAGCCGCACAACATTTCGAAGATAAGAATTCCAAGTGACCACCTTGGCTCTAGTCAGCCAATGGAAAC
GCAAAACGCATTGAAGGGAATGCCTACCAATCAACCGATTTGTTATATCCCTTGGACGAAACAACTTCTG
GAGCAAGATAATCGGGCGTTCCGCAAAGAGTCCATGTGATATCAGGTACCTCCTTCGCGAACCCAAAATC
GGTGATCTTCAGGTGGCCGTGCCGGTCCAGCAGCAGATTCTCAGGCTTCAGGTCCCGGTAGATAATCTGC
TGAGAGTGTAGATACTCCAGTGCAAGAGTCACCTCGGCCGCATAAAACTTGGCGACAGGGTTTGGGAACC
GCTGCAACGGGTCCATGACATCAGCCTACCAAAACTTGCATTGATATGGACGCGAAGAGCACTCACCTGA
GATTTGCGAAGTAAACTAAAGAGCTCTCCGCCCTCCACAAAGTCCATTACCATGTACAGATTCCTTGCAT
CTTGCCAGGTACCCCACAATGTGATCAGGAATGGATGCCTGACACGATTGAGCATTCGTCGCTCGTCATT
CGTATGCTCGACCTGTTTCATTTTGACCACCTGCGCCTTCTTCAGAACCTTGATCGCATAGAAGCGATGA
TTGTGTTTCGACTGCACCAAATGGACACGACCGAAACTACCAGTACCTAGAGTACGTTGTATGGTGAAAT
CGTCTAGGGAATATTTCCCTTTCGTAGTGCGGGCTTCAGTCTGATTGGCCTGCTGGGAGTGTGCATGACC
TTCGGTAGAAGCCTGTGAAGACGCATGATGAGAGGGGTGAAGTATATTGTGTAACCTGGAGGTATGGGAT
TGTTGTTGTGGCTGTTGTTGCTGTTGTTGTAGGTGGTGGAGGCGCGGGTTGTGGTGGGTGGAGGGATGGG
GTTGCGTCACGGCGAATTGCATGGAGGCAGTTTGACCCTCGGATTTTTGATCTGTACCTGAAGAGCGATT
GGGGTTGTCGTTGGATGAGCGATGAGGCTGAGCAGCAGAGGGAGTTGCGGAATTATTGCTGGGGTTACTG
CTGGCCGAATGTTGATGATGGTGGGTTTGATCGTAGTGCTGGTAGTGGTGGTCGTGGTCGGCAGAGTTGG
GTGACGTCTGTGTCTGGGCTGCTGCGGGTGACGAACTTGATTCCAGTTCTTTAGAGAGGGTATGCGAATC
CTTTGTCCGCCGTTTCTTCAAGAGACCTCCTAAAGTCGGCA
Protein Sequence 
>gi|71001742|ref|XP_755552.1| cAMP-dependent protein kinase catalytic subunit PkaC1 [Aspergillus fumigatus Af293]
MPTLGGLLKKRRTKDSHTLSKELESSSSPAAAQTQTSPNSADHDHHYQHYDQTHHHQHSASSNPSNNSAT
PSAAQPHRSSNDNPNRSSGTDQKSEGQTASMQFAVTQPHPSTHHNPRLHHLQQQQQQPQQQSHTSRLHNI
LHPSHHASSQASTEGHAHSQQANQTEARTTKGKYSLDDFTIQRTLGTGSFGRVHLVQSKHNHRFYAIKVL
KKAQVVKMKQVEHTNDERRMLNRVRHPFLITLWGTWQDARNLYMVMDFVEGGELFSLLRKSQRFPNPVAK
FYAAEVTLALEYLHSQQIIYRDLKPENLLLDRHGHLKITDFGFAKEVPDITWTLCGTPDYLAPEVVSSKG
YNKSVDWWSLGILIFEMLCGFTPFWDSGSPVKIYENILRGRVKYPPYLHPDAVDLLSQLITADLTKRLGN
LHGGSEDVKNHPWFAEVTWDRLARKDIDAPYVPPIRGGQGDASQYDRYPEETEQYGQQGEDVHGHLFPDF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pkaC1 mutant is almost avirulent in a low-dose murine inhalation model (Liebmann et al., 2004).
References
Liebmann et al., 2004: Liebmann B, Müller M, Braun A, Brakhage AA. The cyclic AMP-dependent protein kinase a network regulates development and virulence in Aspergillus fumigatus. Infection and immunity. 2004; 72(9); 5193-5203. [PubMed: 15322014].