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pabaA

Victor ID 4555
Gene Name pabaA
Sequence Strain (Species/Organism) Aspergillus fumigatus Af293
NCBI Gene ID 3505208
NCBI Protein GI 70984154
Locus Tag AFUA_6G04820
Genbank Accession AAHF01000012
Protein Accession XP_747596
Taxonomy ID 330879
Chromosome No 6
Gene Starting Position 1127147
Gene Ending Position 1129621
Gene Strand (Orientation) -
Protein pI 5.38
Protein Weight 86080.24
Protein Length 824
DNA Sequence 
>gi|71025133:1127147-1129621 Aspergillus fumigatus Af293 chromosome 6, whole genome shotgun sequence
GCTATGGGTTCAGCGGAGCGAAGATTCCACAGACCGTACGCAACTTAGTCAACATCTCATCCCATTCCCC
CTCGGGAGTACTCAGAGTGGTCACGGCCCCCCCCGCGCCAATTCGCCAGAGTTGCTCGTCATCTTGCTCA
TTTGAGCAGGTAAAAGCTGTGCGGATGAGCACTGAGAAACTGCCCCCGCCACCGAGGTCCAGGAAGCCCA
TCACGCCCGAATAGATCCCACGTTTTCGGTCCTCGATTGAGCTGAGGTGCATGCATGAGCGTTCCTTCGG
GGCACCAGTCATCGAGCCGGGTGGCAGACATCTTTGCAACGCAGTTAGCCCGTATCCAGACATGTTCGAA
GAGGGTAACTGCGGCATATCCCGTGCGGCAAATCCCGGCCGACTTCGATCAACCTTGGCTTTGACATGAG
TGATCATCTGGTAAACACGTCCGTGATCCTCCACTTCCAGGAGTTTTTCTACGTGGACGCCGCCCGAGCC
GCAGATGCCGTAGAGGTCGTGGCGAATCAAATCCGCAATCATGAGATTCTCCGCCATCTCCTTCGTCGAT
CCAAGGATTTCGCGGGCCTTCTCCATGGTCATATCTTCGGTTTTCCTCACAGTGCCCTTCATTGGCTTCA
TTTCCAGCGTAGAGTCCCGATCCCAATTGAGGAAGCATTCCGGACTGCTGCTGGCAATCTTGACGTGACC
TAGTCGCGCAAAACCACTAAAGGCGGCGGGGTTGTACTTTCTCAGACGTTTGTACAGCTCCCAGGGAAAA
CTGGCACGGCCACTTTGACTAACTGGAGAGGGTAACGTGATCAACGTTTCGCCAGTGAGACACAGTTCGT
ACGATTCACCAGCCTCCAACTCAGCCTGACAAGCCCTGATCTGCCTCTGATAATTTTCCTGGGTTGGGAA
TTTGATAACGCTCCGCTTGAGGATGGAATCCAAGAACTCTGCCGTGGTGTCGCTAGTGTAGACCTTGCAC
TGACTCCTGGTAATGGCGAGGTCTTGCAAAAACTGTACGGCCTGATGAAGCCATCCCCTCGGTAGATCAT
CGTCAACCCGCGTTGACTGGACTGTGATTTGGCCCGTCTTGTGATCGACAACGATACTCCTTTCAGTCCA
CAGCAAGCTGGCGTCGGCAGGATCTTCTCCGGCATTTTCATTTTCGCAGGTTGTATGGATTCCTGCAGCT
GTTTTGGGACGTGCAAGACAGGCCAGTCCCATTTCATAGGAAAAGTAACCCAGGAAACCGCCCCAGAACG
GCACAGTGAGACTTCCTGAGTCAACCTTCTTCGTGTCCGTCACAAACCTCAGCACATCCCAGAATTGAGA
GACTGTCAAGGATCTCTCAACAATGCTCTCTGCCACTGACTGCCTAGTCGGACCAATTTCCGTCCCTCGG
CGATCCTGCAGCTTCTCTAACAGCAGGCTTTGAGTCTCACAATAGTACTCGAGCCTCCAGCTGTTGGGGC
TAGGCACCGAGATAATACTATACCTCCCATTAGATTGGAATAGCACGGTTGGCGAGTTGGGGGCATTCAA
GTTCTCGCAGACGACTTCGGCATCCAAGTTTCTCGCTGTAAAGGTACGATATGAAGAACAAGAAGAAGTG
CTGGTGCTCCAATCCAACATTGTGGACGCAGCATCAGGAAGAGTAATACTACCACTGGCGCAGTGGTTAG
AATTGAGCAGAATGCCATATCCTCCGCGCCCCGTCTTTTTGTTGTAATTCAGGGCCATATCCCACCATCT
TCTGAGCAACTTGACGCAAGCTTCCCTGTCAGATTTGCAAGACTCAGGGTGAAACTGCACCCCCCAGATT
GGTCTCTTCTGGTGACGCACAGCCATGGGAATCTGCGTCTCTCCGTCTTCTAGGAGAAACCAAGCTAGAA
GATCAAGGTCCTTGGAAGCGAATCGATCGGCTTGAGGGTTTCCACTGTCAACCCCCCGAGTCGACTGTTC
CGGAGAATCTAGTCTGGCATAAAGCGAGTGATAAAGTGTGACTTCGACATCTTGCACGTTTTCGAAAATG
TCCCTGTTGACAGTCTTGATTCGATGAACCTGGCCATGTAGTGGATACGGCAATCGTCCTATCGGAATGC
CCTGATGGAGACAGAGGCTCTGAAAACCAAGACAGATTCCAAAGACAGGTAACATATCTGCGCCGCTCAG
GGTCCAAACATCCCGCATGATGCCGACATCCTTAGCAACATTCGGATCTCCAGGACCAGGGCCAAGCACG
ACAGCTTCGAAATGCTGTAGATACTCGACCATGTTGCCGTCTGGCCAATCGGAATCGATGGTCATCACCG
AGACTCTAACATCCAGAACCTCTTCGAGCATCGCCACAACATTGTAGGAGAAGGAATCGTATGCATCAAT
GTACAGGACATTCCTTCGAGCAGGAGCATCGACACTCGAGTCGGACGGCTGTCCGGAACCCGACGCCCTC
TCATCATCGCCTATAAATGGCGCCA
Protein Sequence 
>gi|70984154|ref|XP_747596.1| para-aminobenzoate synthase PabaA [Aspergillus fumigatus Af293]
MAPFIGDDERASGSGQPSDSSVDAPARRNVLYIDAYDSFSYNVVAMLEEVLDVRVSVMTIDSDWPDGNMV
EYLQHFEAVVLGPGPGDPNVAKDVGIMRDVWTLSGADMLPVFGICLGFQSLCLHQGIPIGRLPYPLHGQV
HRIKTVNRDIFENVQDVEVTLYHSLYARLDSPEQSTRGVDSGNPQADRFASKDLDLLAWFLLEDGETQIP
MAVRHQKRPIWGVQFHPESCKSDREACVKLLRRWWDMALNYNKKTGRGGYGILLNSNHCASGSITLPDAA
STMLDWSTSTSSCSSYRTFTARNLDAEVVCENLNAPNSPTVLFQSNGRYSIISVPSPNSWRLEYYCETQS
LLLEKLQDRRGTEIGPTRQSVAESIVERSLTVSQFWDVLRFVTDTKKVDSGSLTVPFWGGFLGYFSYEMG
LACLARPKTAAGIHTTCENENAGEDPADASLLWTERSIVVDHKTGQITVQSTRVDDDLPRGWLHQAVQFL
QDLAITRSQCKVYTSDTTAEFLDSILKRSVIKFPTQENYQRQIRACQAELEAGESYELCLTGETLITLPS
PVSQSGRASFPWELYKRLRKYNPAAFSGFARLGHVKIASSSPECFLNWDRDSTLEMKPMKGTVRKTEDMT
MEKAREILGSTKEMAENLMIADLIRHDLYGICGSGGVHVEKLLEVEDHGRVYQMITHVKAKVDRSRPGFA
ARDMPQLPSSNMSGYGLTALQRCLPPGSMTGAPKERSCMHLSSIEDRKRGIYSGVMGFLDLGGGGSFSVL
IRTAFTCSNEQDDEQLWRIGAGGAVTTLSTPEGEWDEMLTKLRTVCGIFAPLNP
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pabaA mutant is attenauted in mice (Brown et al., 2000).
References
Brown et al., 2000: Brown JS, Aufauvre-Brown A, Brown J, Jennings JM, Arst H Jr, Holden DW. Signature-tagged and directed mutagenesis identify PABA synthetase as essential for Aspergillus fumigatus pathogenicity. Molecular microbiology. 2000; 36(6); 1371-1380. [PubMed: 10931287].