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gpaB

Victor ID 4550
Gene Name gpaB
Sequence Strain (Species/Organism) Aspergillus fumigatus Af293
NCBI Gene ID 3510275
NCBI Protein GI 70995816
Locus Tag AFUA_1G12930
Genbank Accession AAHF01000004
Protein Accession XP_752663
Taxonomy ID 330879
Chromosome No 1
Gene Starting Position 3423010
Gene Ending Position 3424403
Gene Strand (Orientation) -
Protein pI 7.49
Protein Weight 39252.64
Protein Length 356
DNA Sequence 
>gi|71025128:3423010-3424403 Aspergillus fumigatus Af293 chromosome 1, whole genome shotgun sequence
ATCACAAGATACCTGAATCTTTCAGGGCATTTTGTAATATTGTTTCCTTGACTGCAGCGAACACTAGACG
AATATTCGTGGTATCCGTTGCTTGAGTCAAACTGTCATGAGGTCAACTTAGTTTGTCAAACTCCCTGAGC
TGGGCCTACTGGCCCCAAGAAGGTACTTACTGTGGATATAGGTTCAGGTGTGCTCGGTTGACCTGGTTAA
ATCTCCACAGGAGATACTTGGCAGCCCGGTTCACATCATTACCGCCAGAGTAATCGGGAAAGTAGTTACT
CAGGGGCGAACGGGGCAATTTCTGTCGAAAGAGATCCACTTTGTTGAGGAAAAGAATAATACTTGTTCGC
ATGAACCATCGTGAATTAACGACAGAGTCAAAAAGAACCAGGCTTTCCATCATTCGATTCTTGAAAGATG
GTTAACAAAGAAAGCCATAGTTCAGTAAATACAGTAATGACTTACTTGATTGCTCTCTTCTAGCAGTACT
TGATCGTACTCACTCAATGCCACACAGAAAATGATCGACGTGACGTTCTCGAAACAATGGATCCATTTTT
TTCGCTCGCTGCGCTGTCCACCGACATCGAACATACTACGGACTCGTTAGTAGCCTAGACTAGGGACAGG
GACAATATTTTGGAAGACAGTCGCATACTGTATGCTGAGCTGGCCCATTGTAAATCTTGTCTCATAGATA
CCTGTCGTCTTTGTTCGAGCTCGGAGGACGTCCGCCACGTTCGGAATATAATCAGGCGCCGCTATGCGCT
TCGCTTCTTCAAAGAAACTAATCGCAGATTGGGTTAATGTGCATATCTCTAGGAAGGCAAAGAATGAACG
TACTATGGCGCAGAATCCATCAGGTAAAACTCATTCTGATGCTCTAACGCAGTGGACGTGCATGGATCAT
TCCAGAGATAGGTGACCGCATCTCCAATTCGAGGATCTAGAGGCGTGTTTGGATCCGGGTCAATATTGTA
TTCAGAAAGGAACTCGATGAATTCGCGGACTTTGGGACTCGTTGGTTGGAGGTTGAATTGGTGGTAAGCT
CCAATGAGAGCTTTGGCGCAATCTAGGAGATTTTTGTAGATCGTTAAACGATATAACGCAAGTTCCTCCA
CTGTGTAGCCGTTTTGATGAATGATTTTCATTTGCTTGACAATTGTAGATTTCCCGCTCTCTCCGGACCC
TGTCGCAAATCAAAGGAAAGCTCCCGTTAGCCCACGGCACAATCACCATTATTATACTCAGAGAAATCCA
GAACTGACCCAGCAGAAGTATCTTGCATTCTCTCCGTAGTCGCCTGGAATCCTCCTCTAACCGGCGATCA
ATGGCCTGACTTCGTTTCTTTTGTTCCGCATCCCCTGGTGACTCTGTGCTGAAACATGACCCCA
Protein Sequence 
>gi|70995816|ref|XP_752663.1| G protein complex alpha subunit GpaB [Aspergillus fumigatus Af293]
MGSCFSTESPGDAEQKKRSQAIDRRLEEDSRRLRRECKILLLGSGESGKSTIVKQMKIIHQNGYTVEELA
LYRLTIYKNLLDCAKALIGAYHQFNLQPTSPKVREFIEFLSEYNIDPDPNTPLDPRIGDAVTYLWNDPCT
STALEHQNEFYLMDSAPYFFEEAKRIAAPDYIPNVADVLRARTKTTGIYETRFTMGQLSIHMFDVGGQRS
ERKKWIHCFENVTSIIFCVALSEYDQVLLEESNQNRMMESLVLFDSVVNSRWFMRTSIILFLNKVDLFRQ
KLPRSPLSNYFPDYSGGNDVNRAAKYLLWRFNQVNRAHLNLYPHLTQATDTTNIRLVFAAVKETILQNAL
KDSGIL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: gpaB mutant is almost avirulent in a low-dose murine inhalation model (Liebmann et al., 2004).
References
Liebmann et al., 2004: Liebmann B, Müller M, Braun A, Brakhage AA. The cyclic AMP-dependent protein kinase a network regulates development and virulence in Aspergillus fumigatus. Infection and immunity. 2004; 72(9); 5193-5203. [PubMed: 15322014].