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gliP

Victor ID 4549
Gene Name gliP
Sequence Strain (Species/Organism) Aspergillus fumigatus Af293
NCBI Gene ID 3508160
NCBI Protein GI 70992013
Locus Tag AFUA_6G09660
Genbank Accession AAHF01000006
Protein Accession XP_750855
Taxonomy ID 330879
Chromosome No 6
Gene Starting Position 2352619
Gene Ending Position 2359123
Gene Strand (Orientation) -
Protein pI 5.82
Protein Weight 219760.75
Protein Length 2135
DNA Sequence 
>gi|71025133:2352619-2359123 Aspergillus fumigatus Af293 chromosome 6, whole genome shotgun sequence
ACTAAAGAACCTGACGGTAAAGACGCTGTGCCAAATCCTGCGCCGTGGGATGATCGAAGATGTTGCAGAT
GGGCACCTCCAGCCCAACCCGTTTCAACTGACGGCTCAACCGCCAGGCCTGGATCGAGTCGCCGCCGGCC
TCGAAGAAGGAGACGGAGCAGGGGAACTCATCCAGCGAGACGCCCAGACAGGTCGCCATCTCACGCTGCA
GAATGCCCACCAGCCGGCGGTAGAAGTTCCAATCCACCTTGGTCCTGGCCGTCTTGTGCATGGCGTTCAG
GCGCTCGTGGATGGCGGCGCGAGAGAGCCGATCCGCCAGCCCTTCGAGGACACATCGGATGCTGTCCTCG
ATGGTGGTGACGGTCGCGTCGTCGAGCTGGTGGTCGTCATACTCGATGCGCAGGGTCCAGTGATCCGCCT
CGATCTCGGTCCATTCGAACATGAGCAGGAACTTGGCCCCGGACGCAAAGCACATCTCGCGTTTCACCTC
CAGCCCCTCGATGGCGAGACAATCTTCCACTGCCCCCTTGAGATGAAAGGTGACCATGGCTTCGAACAGC
GGGTGTTGCCGGATGGTCCGCGGCAGGTGGAGGAGGTTCAGGACCTGCTCGAATGGAATGGAATTGCAGA
CGGCTGCCTGGCTCGCTGCACGCGTAGACTGCAGGATGGTGGCGCAGTCTGCATTCACAGGGGTTTTGAA
GCGAAGAGGCAGGCGATCGAGGAACAGACCCATCGACTCTTGCTCCACGGTGTGCCCGCGGTTGGCCCAC
GGAGAGCCGAGAACGACGTCGTTCGAGCCGGCGAGCCACTGGAGGGTCTGCGCGACGGCGGCACACACCA
GCTGGTGCTGACTCAACCCATGTTCCTGCCCCAGAGTGACGGCGCGTCGAACGAGGTCGCCTTTGAACTC
GGACACGCGCGAGCGGCCTTCAAACGCCATTTGGCCGGGATACCGCGGGATGTCCAGACGCTGGGGAGCC
CCCTCGAGATACTTCGACCAGAACTTCCGTTCCTGCTCTGTGGCCTGACGGGACCAGGCCGGGGCCCGGG
GATAGTGCCATCGGTCCGGTGTTGGGGTCGTCCTTCCCGCGTACACGCCGGAGACGTCCTGCAGCAGATT
CTGCACGCTGTTGAGATCGGCGACGGCGTGGCTGGTAACCACAAGGAGGGTGCGACGGTCCAGGAAGACG
CGGATCAGCTCATCCCGAGCCAGGTCAAAGCTCCGGTCGATCTCCTTGGTCGTGTCGAGCGCACCGTCGC
ACACAAGGACTCGGGGCGGCGTGTCCCGGAAGATCCGACACGGTCCGAGTGATGTCTCGACAAAGTTGGT
CCGGAAGATCTTGCGTGACGCCAACACGGCGTTGAATGACTGCACGAGACGGTCGCGGTCAAATGTCCCG
CCGAGATGCAAGAGGACGGGAATGTTGAACGTGCGCACGTCAGCAGCGATCAGGTACTGGAACCACGTCT
GACGCTCCAACGGCGACAGGCAGTGGTCGGGAAACGCGTCGCAGATGGTCCGTGGCTTGGCCGTCGAGGC
CTGACGTTTGCGGCGCACCAGCTCGACCTGCTCGGCCAGCGTGGAGTGCTCGATCACATCGCGCATCGAC
ACGGAGATGCCAAATGTGCTGCCGAGGCGAGCCGCCAACATCATCTGGAGAACGGAATGGCCGCCCAGAG
CACGGAAGTCATCATCTTCACAGAGCTTGCGAGAGCCGCCGCCTGCCTGCAGACGCAGCACGTTCTTCCA
CAGGGTTGCGATTCCGTCCGCAATAGAAGCATCCTTTGCCGTCATCCCTGCTGGCGTCTTCTGCTGCGGC
AGGGAGTCCTCCGGCCGCGTCAGGGTGGCTCTCTCCGCCAGCTTGCGATAGTCAACCTTGCGGTTGGCCG
TCCAAGGGAACTCCTCCAGCGCGGTAATCACCTGAGGCACCCAGCTGGGTTGGAGGGACTCGCGCAGTCG
CTGCTCCAGACGGCTGACATCCACGTCAAGCGGCATGACAAAGGCCACCAGAGTATCGTTGACAACGAGA
GCCGCCGCTTGGGTAAGCCGCGGCTCCTCTTGGTACATCTTCTGCTCGACCGCCGCGAGCTCGACGCGGA
AGCCACGGATTTTGACCTGCCGGTCCAGTCGTCCGATGTAGACAATCTGTCTGTCCGCGTTCCAGTAGCC
GTAGTCGCCGGTGCGATACATCCGCTCACCAGGATGCCAGGGATCCGGCAGCACGCTGTAGGCCGTCTTG
GCATCGTCTCCCACGTAGCCTCGCATCACCTGTTGTCCGGCCAGGAAGATCTCTCCGGTTTGGCCGTCCG
ACACGGGCTGGAGATCCGGGTCCAGGATGTACATGCGCGCGGTGCGAACGGCGTTTCCGATGGTGACCTG
CTGGCCGGGCTCTAGGCGGGTAAATGACGTGCAAATAGAGCACTAGAGGCGATTAGTCTATATCAAACAC
AAGCATAACACTAGGGGCCTACCTCTGCAGGACCATAGGCATTGTAGAATGCCCGGCCCTCGCCCCATCG
AGCGAGCAAGCCGGGCGTGACGGGTTCTCCTGTTGCATAGACCATGTCGAGATTAGGATAGTCGTCTGGA
TTCAGCACGCTGAGCACAGAAGGAGTAATTGTCGACACATCGACCTTCGCGAGATGGGCAAGGGGGTCGG
ACGGGTCCCGAAGCACCAAGGTTCCGCCATGCAGCAACGCAGAGAAAATCTCGTTGGCACAGTAGTCGAA
CGCAGGCGACATGAACTGAGCTATACGACGACCGGGACGGCTGAACATGGTGGCTTCGGGATTCGACTGC
AAAGCCAGAAGGCCCCTGTGACTGATGGGGACCCCCTTGGGGCGGCCGGTCGTGCCGGAGGTGAAGACGA
TGAGGGCATCCTCATTTGCGTTTGCGAGCAGCGATGGCTGTCTGCTTGTGTCGCTTGTCTCGGTTTCTTG
AATCGTGAAGACGCGAAGATCGGTTATCGGCAGGAGGGCCGCGGACGATGAGCAGGCATTAGGGATGAGG
AGCGCGCTGGCACCGCTTTGTTCGTACACAGCGACCCGTCTCGCGATGGGATACGCAGGATCGAGTGGGC
AGTATGCGCAGCCGGCTTTCAGGATACCCAGGATGCCGACAACCCAGTTGAGGGTTCCATCGGCGTGGAT
GGCGATGACTTGAGCCCTGCTGAAGTGTTTGGCAATATGCGAGGCCACCGCGTTCGACTTTTGATCCAGT
TCCCGGTAGGGTAACGTGCCTCCTGGTCCGTCTACGGCAATCAAATCCTTGTGGAGGTCGACCGAGGCAT
AGAACGCCGACGCCACATTCGGTACATTGACATGTTGGATATCAGAAGCTTGGTCGACGGCAAGCGGTGC
TTTTGTCGGCCCCGTGAGCCATGCCTCCATCGTCGAATCACCCACCAGCGCTTGGAGGGCCTGTTGGAAC
GTGTCGGCATATTGCTGGACCGTCTGCTCGCCGTGCACGGAAGGATTGTACACCAAGCGGAAACGAGCAT
CAGCTTCGACCAGGAGACTCAGCGCAAAGGTCGTGTTCTCGAAGAACTGCTCCTTTTGCGGCGGGATGGG
TTGGTCGTAGGTTGGGAAATCATACTGCGTCGCCAGCAGAGAGTCGACCCGGTACCCGATTTGATCTGGG
GCAGACCATGCGTAGGTGCTAATGGTTGCCAAACCTTCGAACGTGGTCTGCAGCTGGCGCTCAATCGAGG
CTTCTCCGTCAATGCGGCATACCAGGGGCAGAGTGGCCATCAATGGGCCGACGGCCTGCGCATCGTCTGG
GAGGATCTCGCGGCCAGAGAAGACAACTCCCAGAGTTACCAGGGTGGACTTGGTCGTCCGAGCAATCGTC
ATGGCCCACGCCGTGTAGTAGACGGCCGCTAGGGTGACACTGCAGCTGGATGCGAGTCGGTGTAACTCGT
CCACGCCGCCCACATGCTTGAACAGCACCTCCTGAGCGAGGTACGGCCGTGCTACAGGCGTTGTGGTTGC
CTCTGCTTTCGTGAGTGACCGTACCGGCTGCAGATACTGCTCCCAGAACCGCCGTGCCTCGGTGTCTCTC
TGCTTCTGCACGCTCAGCAGATTCCACGCTGCGTCTACAAAGGAAGAGACCCGGGAGGATGCGACACCCT
GGCTTGCCTGCTGCACCCGAGCCAGAATGAGTCCCAGGGAGTAACCATCGATCAGGCTGTGGTGGGCCGT
CCAGACGACAGTCACTTCACCCTCGTCGTCATCGTCGTCATTCGGCATAAATTTCATAAATTCCAAACGC
ATTCCCAGTCCAACCGGCAGACGGGAAGGATCGCTCAAGGCAGCATTGTAGTCTTCCCGGCGGTGAAAGG
TAATCTCCTGCGGCTGGCACCGTGGCTGAGCGTGAACGATCTGCACACCGGGCCCGATATCCAGCGCAAT
CTGCGTTCGGAAGACCGGTTCACTGAGGACGACCTGTCGCCATGCATTGCAGATGTGCTCGGCCGAGGCC
AGGGGATACGATTGCCGCAGCTGGTTCGTGTTGGTCCCATCGCTTTGGAAAATAGGAGCGCTCAGTTGTA
GCTGAAGGGGAGTCAACGGAGCGACGTCAATGTCGCCCAAGAGATGAAGGGCCGCAGCAACCTCGGCCTT
GAGGGATAATCGGTGGTCGATTTGCTCCTCCTTGTCTGGCAAAGGCAGACCAGAATGAGCAAGGTCACGA
GCATACGGGAGAATGCCTCTGACTGTTGGATGTAGGTACAGATCCCGGGTAGTGAGGAGGATGCCTCGCT
CACGGCACAGGGAGGTGAATCGAAGAGCAGCAAGGGAGTTTCCGCCCATGGCGAAGAAATTGAAATCTTT
GGACGCCGACGCCGACGGGAGATCCAACCCCAACGCGGTATACATGCATTCGGCTATGACTTGCTCGCGC
TCCGTAGGACGCTCGCCCCCTGTGGTCTCTTCATCATCGGTGCCCTCGCAGAGACGCGCCTGATACTCTT
TCAGCATGTTCTCAATGGCCTTGGTATCAATCTTGCCGTTGGCTGACAGTGGAAACTGATCGACAGCCAA
GTATCGTCCCGGCCGATGGAAAGAAGACAGCCGACGGTCCGCCTCGCTCTGCAGGCCGTCCAGATCTGCA
GTTGCCGGGGTCACCAGCGCAACCAAGAGACCGTTGATCAGCGAAGCATAGACGTCGGTGACACCGAAGC
CCATCTGGCGTAGCGGTTCCTCGACATCGGCGGGTAGATTGACGAGGAATCCGCGGTTCTTGACGGTGCG
ATCACTGCGGCCGCGGAATTCCACCACGCGCTGGCCGTCGTTACGGCGTGTCCACCGTCCTTGGTCGCCG
GTGCGATAGACTCGCTTGCCGTGCCACTCGATAAACTTCTCGGCTGTTAGTGCGGCATTTCGGTAGTAGC
CGTGGGCCAGGCCGACGCCCGCAATGGCAATCTCCCCTTCCTCGCCTTCTTCCTCGACCGGGAGGAGCGT
ATCCGGCTGTAGCAGGTATACCGGTCCATTGGGCATTGGGCGACCGATAATACTGCGATTGATCATTCCC
GTCTCCTGACAGACCTCTACTTCCTGCATCAACGAGGCACAGGTGGTTTCAGTAGGACCGTACGCGTTCA
GGATGCGAACGCCGAATTGAAGCCAGCTGGACAACAGCGGGGCGGGTGGCGACTCTCCACCCAACAGAAT
AGTATGGACGTAGGGATAGCTGTCTGGCAGGGCCGTCGGCAGGGGTAGTGTTGCCAGGATTGACGGCGTC
GACGCGAGGATGGAGCAGGACTGCGCTTTGTCGAAGAGGGTGTCCATCGTGGCGGGGACCACGATGCCCG
AGTTGCCTAGAATGGAAAACAGCATGCCCGTAGAGGCTATGCCGTGAGCGTTTTGGTCGTAGAAGACAGG
TCCGGATGCTTACCATCAAAGGATACCGACAGGATATGCAGTACCCGGTCTCCCGGCTGCACATCCATGT
TGAATGGACTGGTCTGAGCATAATTGGCTACGGCACGATGTGGAATCATGACTCCCTTGGGCACACCTGT
GCTCCCACTGGTAAAGATCAAACAAGCGAGGTCTTCGGGAGCGATGTCGGGAATGACCTTTGTGGTGCTG
CGGTCCGTCGATAGAGTCGTCACATCGGCGCTGGTCAGATGGATGACTTTGTGCCGCGGGCTTTCGAACG
GCTCGACGGTTGTGTTGATCAGAATCCGGCTGTCTGTCCCGTCCAGCACGGCCTGGATCCGCTCTGATGA
CCACGAGCTGCGGTCCAGAGGAACGTAGCAGGCGTGGGCCTTGAGGATGGCAAGCAGCGCGACAACATTC
CGGGTGCCGTGCTCAGTAAGTAAGAGGACCGCTTCCCCAGGGACTACTCCTTCTTGCTTTAGCTTTCGGG
CCAGGTTCGATGAGGCCACATCGAGTTCGGTATAGGTGAGCGAGCCGCTCTCATGATCGACTGCCAGCTG
GTGTGGTGTCCGAGCGACGGACCGGTCAAAAAGCTGGCAGAGGTCGAGCGCTACTACTGATGGCA
Protein Sequence 
>gi|70992013|ref|XP_750855.1| nonribosomal peptide synthase GliP [Aspergillus fumigatus Af293]
MPSVVALDLCQLFDRSVARTPHQLAVDHESGSLTYTELDVASSNLARKLKQEGVVPGEAVLLLTEHGTRN
VVALLAILKAHACYVPLDRSSWSSERIQAVLDGTDSRILINTTVEPFESPRHKVIHLTSADVTTLSTDRS
TTKVIPDIAPEDLACLIFTSGSTGVPKGVMIPHRAVANYAQTSPFNMDVQPGDRVLHILSVSFDASTGML
FSILGNSGIVVPATMDTLFDKAQSCSILASTPSILATLPLPTALPDSYPYVHTILLGGESPPAPLLSSWL
QFGVRILNAYGPTETTCASLMQEVEVCQETGMINRSIIGRPMPNGPVYLLQPDTLLPVEEEGEEGEIAIA
GVGLAHGYYRNAALTAEKFIEWHGKRVYRTGDQGRWTRRNDGQRVVEFRGRSDRTVKNRGFLVNLPADVE
EPLRQMGFGVTDVYASLINGLLVALVTPATADLDGLQSEADRRLSSFHRPGRYLAVDQFPLSANGKIDTK
AIENMLKEYQARLCEGTDDEETTGGERPTEREQVIAECMYTALGLDLPSASASKDFNFFAMGGNSLAALR
FTSLCRERGILLTTRDLYLHPTVRGILPYARDLAHSGLPLPDKEEQIDHRLSLKAEVAAALHLLGDIDVA
PLTPLQLQLSAPIFQSDGTNTNQLRQSYPLASAEHICNAWRQVVLSEPVFRTQIALDIGPGVQIVHAQPR
CQPQEITFHRREDYNAALSDPSRLPVGLGMRLEFMKFMPNDDDDDEGEVTVVWTAHHSLIDGYSLGLILA
RVQQASQGVASSRVSSFVDAAWNLLSVQKQRDTEARRFWEQYLQPVRSLTKAEATTTPVARPYLAQEVLF
KHVGGVDELHRLASSCSVTLAAVYYTAWAMTIARTTKSTLVTLGVVFSGREILPDDAQAVGPLMATLPLV
CRIDGEASIERQLQTTFEGLATISTYAWSAPDQIGYRVDSLLATQYDFPTYDQPIPPQKEQFFENTTFAL
SLLVEADARFRLVYNPSVHGEQTVQQYADTFQQALQALVGDSTMEAWLTGPTKAPLAVDQASDIQHVNVP
NVASAFYASVDLHKDLIAVDGPGGTLPYRELDQKSNAVASHIAKHFSRAQVIAIHADGTLNWVVGILGIL
KAGCAYCPLDPAYPIARRVAVYEQSGASALLIPNACSSSAALLPITDLRVFTIQETETSDTSRQPSLLAN
ANEDALIVFTSGTTGRPKGVPISHRGLLALQSNPEATMFSRPGRRIAQFMSPAFDYCANEIFSALLHGGT
LVLRDPSDPLAHLAKVDVSTITPSVLSVLNPDDYPNLDMVYATGEPVTPGLLARWGEGRAFYNAYGPAEC
SICTSFTRLEPGQQVTIGNAVRTARMYILDPDLQPVSDGQTGEIFLAGQQVMRGYVGDDAKTAYSVLPDP
WHPGERMYRTGDYGYWNADRQIVYIGRLDRQVKIRGFRVELAAVEQKMYQEEPRLTQAAALVVNDTLVAF
VMPLDVDVSRLEQRLRESLQPSWVPQVITALEEFPWTANRKVDYRKLAERATLTRPEDSLPQQKTPAGMT
AKDASIADGIATLWKNVLRLQAGGGSRKLCEDDDFRALGGHSVLQMMLAARLGSTFGISVSMRDVIEHST
LAEQVELVRRKRQASTAKPRTICDAFPDHCLSPLERQTWFQYLIAADVRTFNIPVLLHLGGTFDRDRLVQ
SFNAVLASRKIFRTNFVETSLGPCRIFRDTPPRVLVCDGALDTTKEIDRSFDLARDELIRVFLDRRTLLV
VTSHAVADLNSVQNLLQDVSGVYAGRTTPTPDRWHYPRAPAWSRQATEQERKFWSKYLEGAPQRLDIPRY
PGQMAFEGRSRVSEFKGDLVRRAVTLGQEHGLSQHQLVCAAVAQTLQWLAGSNDVVLGSPWANRGHTVEQ
ESMGLFLDRLPLRFKTPVNADCATILQSTRAASQAAVCNSIPFEQVLNLLHLPRTIRQHPLFEAMVTFHL
KGAVEDCLAIEGLEVKREMCFASGAKFLLMFEWTEIEADHWTLRIEYDDHQLDDATVTTIEDSIRCVLEG
LADRLSRAAIHERLNAMHKTARTKVDWNFYRRLVGILQREMATCLGVSLDEFPCSVSFFEAGGDSIQAWR
LSRQLKRVGLEVPICNIFDHPTAQDLAQRLYRQVL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: gliP mutant is attenuated in mice immunosuppressed by hydrocortisone (Sugui et al., 2007).
References
Sugui et al., 2007: Sugui JA, Pardo J, Chang YC, Zarember KA, Nardone G, Galvez EM, Müllbacher A, Gallin JI, Simon MM, Kwon-Chung KJ. Gliotoxin is a virulence factor of Aspergillus fumigatus: gliP deletion attenuates virulence in mice immunosuppressed with hydrocortisone. Eukaryotic cell. 2007; 6(9); 1562-1569. [PubMed: 17601876].