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fos-1

Victor ID 4546
Gene Name fos-1
Sequence Strain (Species/Organism) Aspergillus fumigatus Af293
NCBI Gene ID 3508218
NCBI Protein GI 70992129
Locus Tag AFUA_6G10240
Genbank Accession AAHF01000006
Protein Accession XP_750913
Taxonomy ID 330879
Chromosome No 6
Gene Starting Position 2531804
Gene Ending Position 2533930
Gene Strand (Orientation) +
Protein pI 6.3
Protein Weight 73817.52
Protein Length 708
DNA Sequence 
>gi|71025133:2531804-2533930 Aspergillus fumigatus Af293 chromosome 6, whole genome shotgun sequence
AATGGCCCTCGACAAGGAGCTTCTTCACCTTCATCTCGGGGATGGCCAGCAGCGACCCTACAAGCTTTCC
ACGGTCGCTACTCCTCCCGATGAAGAGCAGCTCAATCTTCAACGCAGTGATAAGGATACAGCTGAACCGT
CTCAAACTCCCCGCTGTGACACTCCGCGAGAGGCCCACACAGAGATCGTACAGAACGATACTTCCTCGCT
GAATCGAATTTTCCGCTTCACTCCTGTGCCGACCCTCATCCTCGACTCGTCCTTGCGCGTGATTGAGGTC
TCGGAGAGCCACCTTGCTTTCTGCGGAAAGTCTCGAGACTTTGTGCTGGGTGCCTCCATCTACGAGCTTC
CCCTCGCCACTATACCTGCGCCAGACATTGCGACTCTGAACGGTGCTTTGCACGTGGCGATTACGACTCG
GGCTGTCCAGGTTGTCGAAACTATCCACCTTCCCAGAATAAGCTCTTATTTTTCACTGAAAATCACCCCC
ATTTTCCAGGGATCCACTCTGCTGAACCTAGTTCTGGAAGCGCACAACGTCACAAGGACCCATACCGAGT
CACTGCATAATGCCTACATCAATGAAACTTACAAGATCCTGGTTGACACGATCCGAGATTACGCTATCTT
TATGCTGGACGCGCGCGGCAACATTGTAACGTGGAATTCGGGCGCTGCGTTTATCAAGGGATATAAGGCG
GATGAGATTATCGGTCGGCATTTCTCGGTCTTCTACGGACCCGAGGATCGGCTGGCAGACAAGCCTGGGA
AGGAGCTCGAATTGTGCCTACGGGACGGAAAAGTCGAGGATGAAGGCTGGCGGTATCGTCAGGATGGTTT
ACGGTTTTGGGCCAACGTAATGATTACGCCTATCTTCTCATTCGGTCGGCACGTTGGTTTCGTCAAAATC
ACTCGCGACTTGACCGAGCGCAAAGCGGCTGAAGCGCGGATGGTGGCAGCTTTTGAGGAATCATCCAAGA
TGAAGAGTGACTTCCTGGCCAACATGAGCCACGAGATTCGGACTCCCATGAATGGAATGCACCTGGCATT
GACCATGTTGGGGAGCACGGAGCTCGACACCCAGCAGCGTGAATACACTTCCATTATCGAGGATTCCATG
TCGATTTTGCTTCAAGTAATCAACGACGTCCTTGATTATTCTAAGTTATCCTCCGGCACCTTCTCTCTGA
ACACAGATGTCTTGAGCGTTGAGAATATTGTGGGAGCAGTGGTACGGAATTGCAAGGCCTTAAACCCTGC
CGTGGAGATCTCCTGTTCCATGCCTCCGGGCTTCCCAAAACTGCTCCGGGGTGATCCGCTTCGCTATCGG
CAAGTGATCCAGAACCTCGTGGGAAATGCGATGAAGTTTACCGAGAAAGGCCATGTCAAGGTCACCCATC
GCTTTGCAGTAGAGGAGCACGATGCCAATAGGTACATAATCACGACAGAAGTCACTGATACTGGCATCGG
GGTGCCCGAAGATGCTATAAACACTCTTTTTACCCCATTTACGCGCTTTGCGGATTCAGCCACCAAGCGC
TATCAGGGTACAGGACTTGGCTTGTCCATCTGCAAGAGCTTGGCAGAGCTGATGGCTGGCAGTGTTGGTT
ATAAACCCAACCCAGAAGGAAAGGGTAGCTGCTTTTGGCTCAACGTGAGAATGCAAGCTGTCGACATTCC
AGCGCCTAGTAAAGACACTCCCGCTGCTACCGCCGAAAATACGTACGAACCCATCGAAGAGGTCAAGGAG
ATTGCGCCTCACATGCACATATTGCTGGTGGAAGATAATATGGTGAACCAAATCGTTATGCTGAAGCTTC
TCAAAAGCCTCGGTTTCGAACGTGTCGACACGGCCTGGGACGGCGCAGACGCAGTCCGACAGGTGAAACA
AACACCTCTCTCTTACAATGTTATTCTTATGGACATCAACATGCCGGTTATGAATGGACTCGAAGCAACG
ACCAAGATCCGTGAAGTGAACAGCGAGGTACCCATCATAGCACTCACCGGGAATGCGCTCAAGGGAGACG
CGGAGACATACCTTGCCAGAGGCATGAACGATTACGTCGCCAAACCAGTTCATCGCAAGCGGCTTGTGCA
GTTGTTGTGGAAGTGGCTCGGTTCGTG
Protein Sequence 
>gi|70992129|ref|XP_750913.1| sensor histidine kinase/response regulator Fos-1/TcsA [Aspergillus fumigatus Af293]
MALDKELLHLHLGDGQQRPYKLSTVATPPDEEQLNLQRSDKDTAEPSQTPRCDTPREAHTEIVQNDTSSL
NRIFRFTPVPTLILDSSLRVIEVSESHLAFCGKSRDFVLGASIYELPLATIPAPDIATLNGALHVAITTR
AVQVVETIHLPRISSYFSLKITPIFQGSTLLNLVLEAHNVTRTHTESLHNAYINETYKILVDTIRDYAIF
MLDARGNIVTWNSGAAFIKGYKADEIIGRHFSVFYGPEDRLADKPGKELELCLRDGKVEDEGWRYRQDGL
RFWANVMITPIFSFGRHVGFVKITRDLTERKAAEARMVAAFEESSKMKSDFLANMSHEIRTPMNGMHLAL
TMLGSTELDTQQREYTSIIEDSMSILLQVINDVLDYSKLSSGTFSLNTDVLSVENIVGAVVRNCKALNPA
VEISCSMPPGFPKLLRGDPLRYRQVIQNLVGNAMKFTEKGHVKVTHRFAVEEHDANRYIITTEVTDTGIG
VPEDAINTLFTPFTRFADSATKRYQGTGLGLSICKSLAELMAGSVGYKPNPEGKGSCFWLNVRMQAVDIP
APSKDTPAATAENTYEPIEEVKEIAPHMHILLVEDNMVNQIVMLKLLKSLGFERVDTAWDGADAVRQVKQ
TPLSYNVILMDINMPVMNGLEATTKIREVNSEVPIIALTGNALKGDAETYLARGMNDYVAKPVHRKRLVQ
LLWKWLGS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: fos-1 is attenuated in mice (Clemons et al., 2002).
References
Clemons et al., 2002: Clemons KV, Miller TK, Selitrennikoff CP, Stevens DA. fos-1, a putative histidine kinase as a virulence factor for systemic aspergillosis. Medical mycology : official publication of the International Society for Human and Animal Mycology. 2002; 40(3); 259-262. [PubMed: 12146755].