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UL41

Victor ID 4525
Gene Name UL41
Sequence Strain (Species/Organism) Suid herpesvirus 1
NCBI Gene ID 2952522
NCBI Protein GI 51557510
Locus Tag SuHV1_gp27
Genbank Accession S57917
Protein Accession YP_068344
Taxonomy ID 10345
Gene Starting Position 50399
Gene Ending Position 51570
Gene Strand (Orientation) -
Protein Name tegument host shutoff protein
Protein pI 8.4
Protein Weight 37834.55
Protein Length 365
DNA Sequence 
>gi|51557483:50399-51570 Suid herpesvirus 1, complete genome
TTTTATTTTCTCCTATGGGCGTTACAGTCGTCCCAGTACGCCATGAGGACGGCCTGGTAGTTCGGGGGCG
GGGGTATGTGTTTCCAAAACAGGCCCGCCAGCTCCTTCGCCCGCGTCTCGTTCTTCACGTGCCGCAGCAG
CGAGCCAAAGACCTTGTTCACGTCCGAGGGCTCCTGCACGATGGGGACGCGCCGCAGCACGCTCAGGTGC
CCGTGCCGCGCCGGCGTGAGCATGGCCACCACGTGCTGGATGAACTCGCGCTCGGCGCGCGGCGAGCGCG
CGTCCCCGGCCGCCGGCAGCAGGGCGAGCGCCTTGCCGGCGTCGCGCATGATGTCGGGGCAGCGGGAGGC
GTACTTGAGCTTGACGTCCTCGGGGGCCACCTCGCGGCCCTCCAGCGACTCGGCCACCTGCTGCACCGAG
TCCACGTCCGGCGCCCGGTGCAGGTCCGTGTGGCAGCGCACGAACGCGGCCAGGAACTCCGAGTAGTCCA
CCCCCAGGCTCGCGAGGACGTCGCGGCAGCGCAGCACCAGCGGGAACACGGGCGCGATGTCGAGGATCAT
GTCGCACCCGGTGAGGATCATGTCCGTGTCCGTCGTGTGCACCTGCGCGACCGTGTTGGTGTGGTAGAGG
TTGGCGCAGACGTCGTCCGCCTCCATGTCCGACACGTCCACGTAGGCGTAGCCCATGTGGCGGATGAGGT
TGACGCAGAGGCGGTGGACGATGCGCGGCGCGTGCAGCATCGTGCTCCAGCGCGGCCGCGGCGGCGCGTC
GGCGGCCCCGTCGCCGTCGGCGCGCACGGCCGCGGCCATGATGGCCTTGGCGCCGCGCGCGATGCGGCCG
TTCCCGAAGATGCCGCGGTCCGAGACGAAGATGGGGAAGTAGGTGCGCTTGTGCAGCATGCGCAGCAGGC
GCAGCAGGCAGCGGGCGGTCGTGGTCGCGTTGTCCTCGGTCGTCTCCTGGTAGTGCTTCTCCATGAGGGT
GTACATGACGTTCCACAGGTCGATGGCGATTGGCGTGAGGACCCCCGGCGGCGTGGAGATGGCCTCCGAG
CGCACCAGACGGTGGCGGTGTGCGTACTTTAAAAGGCCAAAGAGCCCCATGTCTCCGCTCGCACACCGAG
GCGCCGGTCTAAAATACGCATGTGGCGGGGCGGGGCCATCCCGCGCATATAA
Protein Sequence 
>gi|51557510|ref|YP_068344.1| tegument host shutoff protein [Suid herpesvirus 1]
MGLFGLLKYAHRHRLVRSEAISTPPGVLTPIAIDLWNVMYTLMEKHYQETTEDNATTTARCLLRLLRMLH
KRTYFPIFVSDRGIFGNGRIARGAKAIMAAAVRADGDGAADAPPRPRWSTMLHAPRIVHRLCVNLIRHMG
YAYVDVSDMEADDVCANLYHTNTVAQVHTTDTDMILTGCDMILDIAPVFPLVLRCRDVLASLGVDYSEFL
AAFVRCHTDLHRAPDVDSVQQVAESLEGREVAPEDVKLKYASRCPDIMRDAGKALALLPAAGDARSPRAE
REFIQHVVAMLTPARHGHLSVLRRVPIVQEPSDVNKVFGSLLRHVKNETRAKELAGLFWKHIPPPPNYQA
VLMAYWDDCNAHRRK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A UL41 mutant is highly attenuated in mice (Lin et al., 2010).
References
Lin et al., 2010: Lin HW, Hsu WL, Chang YY, Jan MS, Wong ML, Chang TJ. Role of the UL41 protein of pseudorabies virus in host shutoff, pathogenesis and induction of TNF-α expression. The Journal of veterinary medical science / the Japanese Society of Veterinary Science. 2010; 72(9); 1179-1187. [PubMed: 20448414].