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guaA

Victor ID 4503
Gene Name guaA
Sequence Strain (Species/Organism) Pasteurella multocida subsp. multocida str. Pm70
NCBI Gene ID 1243640
NCBI Protein GI 15602158
Locus Tag PM0293
Genbank Accession AE004439
Protein Accession NP_245230
Taxonomy ID 272843
Gene Starting Position 334537
Gene Ending Position 336108
Gene Strand (Orientation) -
Protein Name GMP synthase
Protein pI 5.95
Protein Weight 53467.86
Protein Length 523
Protein Note contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
DNA Sequence 
>gi|15601865:334537-336108 Pasteurella multocida subsp. multocida str. Pm70, complete genome
GTTATTCCCACTCAATTGTTGCTGGCGGCTTACCGCTAACGTCATAAACAACGCGAGAAATCCCATTGAC
TTCATTAATAATACGATTGGAAATTTTACCTAAGAGATCATAAGGCAGGTGTGCCCAATGTGCGGTCATA
AAATCGATTGTTTCCACTGCACGGAGGGAAACTACCCAGTCATATTTACGCCCATCACCCATGACACCTA
CGGATTTTACTGGTAAAAATACCGTGAAGGCTTGGCTGACTTTGTAGTACCAACCAGAAGCATGCAACTC
TTCCATAAAGATCGCATCAGCAAGGCGGACTAAATCACAGTATTCTTTTTTGATTTCACCTAAAACACGG
ACACCTAAACCAGGTCCTGGGAATGGGTGACGATTTAACATTTCGGCTGGTAAACCTAATGCTAAACCAA
TTTTACGTACTTCATCTTTAAATAATTCACGAAGTGGTTCAACAAGTCCTAGCTTCATGTAGTCAGGTAA
ACCACCGACGTTATGGTGTGATTTAATCACATGTGCTTTACCTGTTTTACTTGCCGCAGACTCAATAACA
TCTGGATAAATCGTGCCTTGGGCTAACCATTTGACGCTGGTGAGTTTTTTCGATTCATCATCAAAAACAT
CCACAAAGACTTTACCAATCATTTTACGTTTTGCTTCGGGCTCATCGATGCCTTTTAACGCATCTAAGAA
ACGATCTTCTGCTTTTACGTGGATAATGTTTAAACCAAATTTATCGCCAAACATCTCCATCACTTGTTCC
GCTTCGTTGAGACGTAATAAACCGTTATCTACGAAAACACAGTGTAAGTTTTTACCAATCGCACGATGTA
AGAGTAGTGCAGTGACAGAAGAGTCAACGCCACCAGATAATCCTAAGATCACTTCATCATCACCCACTTG
TGCTTTAAGACGAGCAACGGCATCTTCAATGATATTTTCTGGTGTCCAGTTACGTTCACAACCACAGATC
TTCACCACAAAATTCGTTAATAATTCAAGCCCGCTTTTTGTATGAGTCACTTCTGGGTGGAATTGGACAC
CATAAAAACGACGACGTTCATCCGACATAGCTGCAATTGGACAGGTTGAGGTCATTGCGGTGACTTGGAA
ATGATCTGGCAAACGCGTCACTTTATCGCCATGGCTCATCCAAACGTCTAATTTGGGCTGTGAACTTGTG
ACATCATCATTTAATTGAGCAAATAACGCGTCCGCTGCTTTTAGATTCACTGATGCATAACCAAATTCTC
GGTGAGTAGAAGTTTCAGTTAAACCACCTAGTTGCATCGCCATGGTTTGCATACCATAACAGATCCCTAA
TACGGGTACACCGGCGTTGAATACGTATTCGGGAGCTCGTGGGCTGTTTTCTTCAGTGGTACTTTCAGGA
CCACCAGAAAGAATAATCCCAGTTGGATTAAACTCACGAATATCGGCTTCGGAAACATCCCATGCCCAAA
GTTCGCAGTACACGCCAATTTCACGTACACGGCGGGCAATCAACTGGGTATATTGTGAACCGAAGTCCAA
AATTAAAATTTTATGGTTGTGAATGTTGTTCA
Protein Sequence 
>gi|15602158|ref|NP_245230.1| bifunctional GMP synthase/glutamine amidotransferase protein [Pasteurella multocida subsp. multocida str. Pm70]
MNNIHNHKILILDFGSQYTQLIARRVREIGVYCELWAWDVSEADIREFNPTGIILSGGPESTTEENSPRA
PEYVFNAGVPVLGICYGMQTMAMQLGGLTETSTHREFGYASVNLKAADALFAQLNDDVTSSQPKLDVWMS
HGDKVTRLPDHFQVTAMTSTCPIAAMSDERRRFYGVQFHPEVTHTKSGLELLTNFVVKICGCERNWTPEN
IIEDAVARLKAQVGDDEVILGLSGGVDSSVTALLLHRAIGKNLHCVFVDNGLLRLNEAEQVMEMFGDKFG
LNIIHVKAEDRFLDALKGIDEPEAKRKMIGKVFVDVFDDESKKLTSVKWLAQGTIYPDVIESAASKTGKA
HVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMLNRHPFPGPGLGVRVLGEIKKEYCD
LVRLADAIFMEELHASGWYYKVSQAFTVFLPVKSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDL
LGKISNRIINEVNGISRVVYDVSGKPPATIEWE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: guaA mutant is attenuated in mice (Fuller et al., 2000).
References
Fuller et al., 2000: Fuller TE, Kennedy MJ, Lowery DE. Identification of Pasteurella multocida virulence genes in a septicemic mouse model using signature-tagged mutagenesis. Microbial pathogenesis. 2000; 29(1); 25-38. [PubMed: 10873488].