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prM

Victor ID 4488
Gene Name prM
Sequence Strain (Species/Organism) Yellow fever virus
NCBI Protein GI 222778
Other Database IDs CDD:144552
CDD:110567
CDD:110035
CDD:109907
CDD:145801
CDD:109983
Taxonomy ID 11089
Gene Strand (Orientation) ?
Protein Name precursor polyprotein
Protein Length 1163
Protein Note Flavivirus capsid protein C; pfam01003
Protein Sequence 
>gi|222778|dbj|BAA03355.1| precursor polyprotein [Yellow fever virus]
MSGRKAQGKTLGVNMVRQGVRSLSNKIKQKTKQIGNRPGPSRGVQGFIFFFLFNVLTGRKITAHLKKLWR
MLDPRQGLAVLKKVKRVVASLMRGLSSRKRRSYEVLTVQFLILGMLLMTGGVTLVRKSRWLLLNVTSEDL
GKTFSVGTGNCTTNILEAKNWCPDSMEYNCPNLSPREEPDDIDCWCYGVENVRVAYGKCDSAGRSRRSRR
AIDLPTHENHGLKTRQEKWMTGRMGERQLQKIERWLVRNPFFAVTALAIAYLVGSNMTQRVVIALLVLAV
GPAYSAHCIGITDRDFIEGVHGGTWVSATLEQDKCVTVMAPDKPSLDISLETVAIDGPAEARKVCYSAVL
THVKINDKCPSTGEAHLAEENEGDHACKRTYSDRGWGNGCGLFGKGSIVACAKFTCAKSMSLFEVDQTKI
QYVIRAQLHVGAKQENWNADIKTLKFDALSGSQEAEFTGYGKATLECQVQTAVDFSNSYIAEMEKESWIV
DRQWAQDLTLPWQSGSGGVWREMHHLVEFEPPHAATIKVLALGNQEGSLKTALTGAMRVTKDTNGSNLYK
LHGGHVSCRVKLSALTLKGTSYKMCTDKMSFVKNPTDTGHGTAVMQVKVPKGAPCRIPVMVADDLTASVN
KGILVTVNPIASTNEDEVLIEVNPPFGDSYIIVGTGDSRLTYQWHKEGSSIGKLFTQTMKGAERLAVMGD
AAWDFSSAGGFFTSVGKGIHMVFGSAFQGLFGGLSWITKVIMGAVLIWVGINMRNMTMSMSMILVGVIMM
FLSLGVGADQGCAINFGKRELKCGDGVFIFRDSDDWLNKYSYYPEDPVKLASIVKASFEEGKCGLNSVDS
LEHEMWRSRADEINAILEENEVDISVVVQDPKNIYQRGTHPFSRIRDGLQYGWKTWGKNLVFSPGRKNGS
FIIDGKSRKECPFSNRVWNSLQIEEFGTGVFTTRVYMDAVFEYTMDCDGSILGAAVNGKKSAHGSPTFWM
GSHEVNGTWMIHTLETLDYKECEWPLTHTIGTSVEESDMFMPRSIGGPVSSHNHIPGYKVQTNGPWMQVP
LEVKREACPGTSVVVDGGCDGRGKSTRSTTDSGKIIPEWCCRSCTMPPVSFHGSDGCWYPMEIRPRKTHD
NHLVRSWVTAGEVHAVPFGLVSMMIAMEVFLKKRQGPKQILVG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A mutation in the prM signal sequence led to attenuation in the neurovirulence in mice (Lee et al., 2000).
References
Lee et al., 2000: Lee E, Stocks CE, Amberg SM, Rice CM, Lobigs M. Mutagenesis of the signal sequence of yellow fever virus prM protein: enhancement of signalase cleavage In vitro is lethal for virus production. Journal of virology. 2000; 74(1); 24-32. [PubMed: 10590087].