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NS3

Victor ID 4487
Gene Name NS3
Sequence Strain (Species/Organism) Yellow fever virus
NCBI Protein GI 27735293
Other Database IDs CDD:144519
CDD:28927
CDD:175389
Taxonomy ID 11089
Gene Strand (Orientation) ?
Protein Name non-structural protein NS3
Protein Length 623
Protein Note virion RNA mosquito-borne
Protein Sequence 
>gi|27735293|ref|NP_776005.1| non-structural protein NS3 [Yellow fever virus]
SGDVLWDIPTPKIIEECEHLEDGIYGIFQSTFLGASQRGVGVAQGGVFHTMWHVTRGAFLVRNGKKLIPS
WASVKEDLVAYGGSWKLEGRWDGEEEVQLIAAVPGKNVVNVQTKPSLFKVRNGGEIGAVALDYPSGTSGS
PIVNRNGEVIGLYGNGILVGDNSFVSAISQTEVKEEGKEELQEIPTMLKKGMTTVLDFHPGAGKTRRFLP
QILAECARRRLRTLVLAPTRVVLSEMKEAFHGLDVKFHTQAFSAHGSGREVIDAMCHATLTYRMLEPTRV
VNWEVIIMDEAHFLDPASIAARGWAAHRARANESATILMTATPPGTSDEFPHSNGEIEDVQTDIPSEPWN
TGHDWILADKRPTAWFLPSIRAANVMAASLRKAGKSVVVLNRKTFEREYPTIKQKKPDFILATDIAEMGA
NLCVERVLDCRTAFKPVLVDEGRKVAIKGPLRISASSAAQRRGRIGRNPNRDGDSYYYSEPTSENNAHHV
CWLEASMLLDNMEVRGGMVAPLYGVEGTKTPVSPGEMRLRDDQRKVFRELVRNCDLPVWLSWQVAKAGLK
TNDRKWCFEGPEEHEILNDSGETVKCRAPGGAKKPLRPRWCDERVSSDQSALSEFIKFAEGRR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: NS3 mutant results in failure to recover infectious virus from transfected mammalian cells (Chambers et al., 1990).
References
Chambers et al., 1990: Chambers TJ, Weir RC, Grakoui A, McCourt DW, Bazan JF, Fletterick RJ, Rice CM. Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein. Proceedings of the National Academy of Sciences of the United States of America. 1990; 87(22); 8898-8902. [PubMed: 2147282].