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A2

Victor ID 4482
Gene Name A2
Sequence Strain (Species/Organism) Leishmania infantum
NCBI Nucleotide GI 546453
NCBI Protein GI 546454
Protein Accession AAB30592.1
Taxonomy ID 5671
Gene Strand (Orientation) ?
Protein Name stage-specific S antigen homolog
Protein Length 2817
Protein Note Plasmodium falciparum S antigen homolog
DNA Sequence 
>gi|546453|gb|S69693.1| Leishmania donovani infantum stage-specific S antigen homolog (A2) mRNA, complete cds
GAGCTCCCCCAGCGACCCTCTCGGCAACGCGAGCGCCCCAGTCCCCCCACGCACAACTTTGACCGAGCAC
AATGAAGATCCGCAGCGTGCGTCCGCTTGTGGTGTTGCTGGTGTGCGTCGCGGCGGTGCTCGCACTCAGC
GCCTCCGCTGAGCCGCACAAGGCGGCCGTTGACGTCGGCCCGCTCTCCGTTGGCCCGCAGTCCGTCGGCC
CGCTCTCTGTTGGCCCGCAGGCTGTTGGCCCGCTCTCCGTTGGCCCGCAGTCCGTCGGCCCGCTCTCTGT
TGGCCCGCAGGCTGTTGGCCCGCTCTCTGTTGGCCCGCAGTCCGTTGGCCCGCTCTCCGTTGGCCCGCTC
TCCGTTGGCCCGCAGTCTGTTGGCCCGCTCTCCGTTGGCTCGCAGTCCGTCGGCCCGCTCTCTGTTGGTC
CGCAGTCCGTCGGCCCGCTCTCCGTTGGCCCGCAGGCTGTTGGCCCGCTCTCCGTTGGCCCGCAGTCCGT
CGGCCCGCTCTCTGTTGGCCCGCAGGCTGTTGGCCCGCTCTCTGTTGGCCCGCAGTCCGTTGGCCCGCTC
TCCGTTGGCCCGCAGTCTGTTGGCCCGCTCTCCGTTGGCTCGCAGTCCGTCGGCCCGCTCTCTGTTGGTC
CGCAGTCCGTCGGCCCGCTCTCCGTTGGCCCGCAGTCTGTCGGCCCGCTCTCCGTTGGCCCGCAGTCCGT
CGGCCCGCTCTCCGTTGGTCCGCAGTCCGTTGGCCCGCTCTCCGTTGGCCCGCAGTCCGTTGACGTTTCT
CCGGTGTCTTAAGGCTCGGCGTCCGCTTTCCGGTGTGCGTAAAGTATATGCCATGAGGCATGGTGACGAG
GCAAACCTTGTCAGCAATGTGGCATTATCGTACCCGTGCAAGAGCAACAGCAGAGCTGAGTGTTCAGGTG
GCCACAGCACCACGCTCCTGTGACACTCCGTGGGGTGTGTGTGACCTTGGCTGCTGTTGCCAGGCGGATG
AACTGCGAGGGCCACAGCAGCGCAAGTGCCGCTTCCAACCTTGCGACTTTCACGCCACAGACGCATAGCA
GCGCCCTGCCTGTCGCGGCGCATGCGGGCAAGCCATCTAGATGCGCCTCTCCACGACATGGCCGGAGGCG
GCAGATGAAGGCAGCGACCCCTTTTCCCCGGCCACGACGCCGCGCTGAGGCGGGCCCCACAGCGCAGAAC
TGCGAGCGCGGTGCGCGGGCGCTGTGACGCACAGCCGGCACGCAGCGTACCGCACGCAGACAGTGCATGG
GGAGGCCGGAGGAGCAAGAGCGGTGGACGGGAACGGCGCGAAGCATGCGGCACGCCCTCGATGTGCCTGT
GTGGGCTGATGAGGCGCGGATGCCGGAAGCGTGGCGAGGGCATCCCGAGTTGCACCGTCGAGTCCTCCAG
GCCCGAATGTGGCGAGCCTGCGGGGAGCAGATTATGGGATGCGGCTGCTCGAAGCGACCGAGGGCGCTGA
CCGGAAGGTGGCCCACTTCCTCCTCGGGCCTGTGCGGCATCCGCCCTCGATCGGGAGCCCGAATGGTGGC
CGCGCGGGTGAAGGCGTGCCGCCCACCCGCGTCTCCGTGTGGCGCCGCTGGGGGCAGGTGCGCTGTGGCT
GTGTATGTGCGCTGATGTGCTGACTTGTTCGTGGTGGGCTATGGGCACGGTGAGGGGCGACGTTGGCCCT
TGCTGACTTCCTCTGCTTTCTTATTATTCTCAGTGCCCCCGCTGGATTGGGCTGCATCGGCGGTCTGTAT
CGCGCTTGTCTCTCTCATTTGACGGCTGCGCGCCTCCCGCCCCTCCCACTCGTGCTGTGGGATGGAGGCA
CGGCCGGGCTCTGTGTTGTGTGCACCGCGTGCAAGAATTCAGATGAGGGACTGCCGAGCGAGCAGACAAA
GCAGCAGCAGCAACAGGAAGGCAGGCCTGAGCACGTTTTCTTTTCTCTCTTGAGACTGCGGACTACGGGA
ATCAGAGACGTCGTCAGAGACGCGCATCCGCACCCGCGCGCTATGCTTCCTCGTTCTCTCTCCCGCCCCA
TTCTGTGCGCCTGCCTGTCTGCGTGTCGCGAGCGCCGTTGCCGGCGGTCTCTCTCCCCTCCCTTCGCTTC
TCTCTTGCAAGCGCTTCCTTTTTCACAGCCGAACGTTGCTGCTCGCCTGGAGGCCGTTCCCCCTCTTATC
ATCTCTGCATTTATTTTTACACGTGCTTTTGCTTTGGCTTCCTGACGATGCCGGCCACCTCACCGCGGTG
TCAGGGCCCAGCGCCCACTCTTTGTGGGCAGGCCAAGTAGCCTGCAGCCTGCCCATGAGCACGGCTGTGG
ACTCTTGGTGCCAGCGGACAGGTGTGGGCTGGCGCTGTGCCGGTGACACCAACGGTCATGATGACGCTTG
GACCAGCTCACTGCGGATCATGCCGACGATTCAACGAATGCGCGCATCCACCTACTGCCTTTCTGCCTTT
GCTGCGCTGCGGTGGTGCTGAGCGTGGTCCCGGGGCCTAGCCTGCGCTGTACGCAGCGGCATTGCGGTGG
GCTGAGCGGCGCCAGGCGGTGCTGGCCGGCCCTGCTGCTTGGCATAGCCGTGGCGTGCAGCAGATGCGGA
TGGGCTGTGGCTGCGCATGCGTGTGTGCGTTGACTTGTTCGTGGTGGGCGGGCACGTAAACGGCAAAATG
CGCTTTGGCGTTCCGGCGCCACGCTCCGGCGCTGGTGCGGTATTCGAATACGCGCCTGAAGAGGTGGCGA
GGAAAATGGCACGAGGCGCAGAGGGAAAAAACGAAAAGTGCAAAGTGCGCAAACCGCGCAGAAAATGCGG
GAAAAACGAAAAGTGCA
Protein Sequence 
>gi|546454|gb|AAB30592.1| stage-specific S antigen homolog [Leishmania infantum]
MKIRSVRPLVVLLVCVAAVLALSASAEPHKAAVDVGPLSVGPQSVGPLSVGPQAVGPLSVGPQSVGPLSV
GPQAVGPLSVGPQSVGPLSVGPLSVGPQSVGPLSVGSQSVGPLSVGPQSVGPLSVGPQAVGPLSVGPQSV
GPLSVGPQAVGPLSVGPQSVGPLSVGPQSVGPLSVGSQSVGPLSVGPQSVGPLSVGPQSVGPLSVGPQSV
GPLSVGPQSVGPLSVGPQSVDVSPVS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: RNA silencing of A2 gene leads to attenuated virulence in mice (Zhang and Matlashewski, 1997).
References
Zhang and Matlashewski, 1997: Zhang WW, Matlashewski G. Loss of virulence in Leishmania donovani deficient in an amastigote-specific protein, A2. Proceedings of the National Academy of Sciences of the United States of America. 1997; 94(16); 8807-8811. [PubMed: 9238059].