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URE

Victor ID 4472
Gene Name URE
NCBI Protein GI 60280325
Protein Accession AAC49868.3
Taxonomy ID 199306
Gene Strand (Orientation) ?
Protein Name urease
Protein Length 5588
Protein Note human respiratory pathogen
Protein Sequence 
>gi|60280325|gb|AAC49868.3| urease [Coccidioides posadasii]
MQLVPREIDKLTISNLGFLAQRRLARGVRLNHAEATALIASNLQLIRDGNNSVADLMTIGKEMLGRRHVL
PSVVATLKQVQVEGTFPTGTNLITVVNPVCSDDGDLEKALYGSFLPVPPKETFPDPDPDDYQPEKMPGAV
IPLKTSKKIELNAGRNRIMLKVTSRGDRPIQVGSHYHFIEVNPQLDFDRAKAYGYRLDIPAGTSIRFEPG
ATKAIPLVEIGGKRIIRGGNHIAVGQVDFRRVDEIIMRLQKAGFAYTPEPKQDAHLIEPFSMTREAYARM
FGPTTGDVVKLGTTDLWIKVEKDLTYYGDECSFGGGKTIRDGMGQATGRHSVDVLDTVLVNALIVDWTGI
YKADIGLKDGLICGIGKAGNPDMMDGVTPNMIVGSSTDVIACEGKIVTAGGIDTHVHFICPQQVEEALAS
GVTTLLGGGTGPTEGSNATTCTPAPNQFKTMMQACDHLPINVGLTGKGNDSGLPSLRDQCRAGAAGLKVH
EDWGATPAVIDTCLQVCDEFDIQCLIHTDTLNESGFVEQTINAFKNRVIHTYHTEGAGGGHAPDIISVVE
KPNVLPSSTNPTRPYTVNTLDEHLDMVMVCHHLSKDIPEDVAFAESRIRSETIAAEDVLHDTGAISMLSS
DSQAMGRCGEVVVRTWNTAHKNKMERGRLKEDEGTDSDNFRVKRYISKYTINPAIAQGMAHTIGSVEVGK
TADLVLWKFANFGTKPSMVLKSGMAVSAQMGDPNGSIPTIEPIIMRPMYASLNPKASIMFVSQASIKLGI
IDSYHLKKRIEPVKNCRNISKRDMKFNDIMPKMRVDPESYVVEADGEECTAEPVSELPLTQDYFVY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ure mutant is attenuated in mice (Mirbod-Donovan et al., 2006).
References
Mirbod-Donovan et al., 2006: Mirbod-Donovan F, Schaller R, Hung CY, Xue J, Reichard U, Cole GT. Urease produced by Coccidioides posadasii contributes to the virulence of this respiratory pathogen. Infection and immunity. 2006; 74(1); 504-515. [PubMed: 16369007].