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MEP1

Victor ID 4471
Gene Name MEP1
NCBI Protein GI 33323431
Other Database IDs CDD:58575
Taxonomy ID 199306
Gene Strand (Orientation) ?
Protein Name metalloprotease 1 precursor
Protein Length 276
Protein Note Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor...; cd04275
Protein Sequence 
>gi|33323431|gb|AAQ07436.1| metalloprotease 1 precursor [Coccidioides posadasii]
MRVSVPVLALAFGSLAAAAPNAGRRTCGSVPPPEFFEASEKVAALEESGAFADLQAPIEVETYFHVVASS
RSERDGYISDQMLSDQIRVMNEDYAPHGVHFNLRETTRTINPSWASDGNEIAMKRSLRKGGYAALNVYFL
KDLGGALGYCYFPTNAAPGSTTFIRDGCSVLSSSVPGGSGAPYDLGKTATHEVGHWMGLFHTFQGGCSGQ
GDYVSDTPPQRSPSSGCPVGRDSCPGGGVDPIHNYMDYSVDSCMNQFTRGQGTRMSSMWRQFRAGK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mep1 mutant is attenuated in mice (Hung et al., 2005).
References
Hung et al., 2005: Hung CY, Seshan KR, Yu JJ, Schaller R, Xue J, Basrur V, Gardner MJ, Cole GT. A metalloproteinase of Coccidioides posadasii contributes to evasion of host detection. Infection and immunity. 2005; 73(10); 6689-6703. [PubMed: 16177346].