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toxA from Pseudomonas aeruginosa LESB58

Victor ID 4448
Gene Name toxA from Pseudomonas aeruginosa LESB58
Sequence Strain (Species/Organism) Pseudomonas aeruginosa LESB58
NCBI Gene ID 7178280
NCBI Protein GI 218892886
Locus Tag PLES_41711
Protein Accession YP_002441755.1
Other Database IDs UniProtKB-ID: B7UX39_PSEA8
UniRef100: UniRef100_B7UX39
UniRef90: UniRef90_P11439
UniRef50: UniRef50_P11439
UniParc: UPI000188FAB3
EMBL: FM209186
EMBL-CDS: CAW28926.1
RefSeq_NT: NC_011770.1
GenomeReviews: FM209186_GR
KEGG: pag:PLES_41711
HOGENOM: HBG639690
OMA: AHESNEM
ProtClustDB: CLSK545809
Taxonomy ID 557722
Gene Starting Position 4604845
Gene Ending Position 4606761
Gene Strand (Orientation) +
Protein Name exotoxin A precursor
DNA Sequence 
>gi|218888746:4604845-4606761 Pseudomonas aeruginosa LESB58, complete genome
GATGCACCTGATACCCCATTGGATCCCCCTGGTCGCCAGCCTCGGCCTGCTCGCCGGCGGCTCGTCCGCG
TCCGCCGCCGAGGAAGCCTTCGACCTCTGGAACGAATGCGCCAAGGCCTGCGTGCTCGACCTCAAGGACG
GCGTGCGTTCCAGCCGCATGAGCGTCGACCCGGCCATCGCCGACCCCAACGGCCAGGGCGTGCTGCACTA
CTCCATGGTCCTGGAGGGCGGCAACGACGCACTCAAGCTGGCCATCGACAACGCCCTCAGCATCACCAGC
GACGGCCTGACCATCCGCCTCGAAGGCGGCGTCGAGCCGAACAAGCCGGTGCGCTACAGCTACACGCGCC
AGGCGCGCGGCAGTTGGTCGCTGAACTGGCTGGTACCGATCGGCCACGAGAAGCCTTCGAACATCAAGGT
GTTCATCCACGAACTGAACGCCGGTAACCAGCTCAGCCACATGTCGCCGATCTACACCATCGAGATGGGC
GACGAGTTGCTGGCGAAGCTGGCACGCGATGCCACCTTCTTCGTCAGGGCGCACGAGAGCAACGAGATGC
AGCCGACGCTCGCCATCAGCCATGCCGGGGTCAGCGTGGTCATGGCCCAGGCCCAGCCGCGCCGGGAAAA
GCGCTGGAGCGAATGGGCCAGCGGCAAGGTGTTGTGCCTGCTCGACCCGCTGGACGGGGTCTACAACTAC
CTCGCCCAGCAGCGCTGCAAGCTCGACGATACCTGGGAAGGCAAGATCTACCGGGTGCTCGCCGGCAACC
CGGCGAAGCATGACCTGGACATCAAGCCCACGGTCATCAGTCATCGCCTGCATTTCCCCGAGGGCGGCAG
CCTGGCCGCGCTGACCGCGCACCAGGCCTGCCACCTGCCGCTGGAGACCTTCACCCGTCATCGCCAGCCG
CGCGGCTGGGAACAACTGGAGCAGTGCGGCTATCCGGTGCAGCGGCTGGTCGCCCTCTACCTGGCGGCGC
GGCTGTCGTGGAACCAGGTCGACCAGGTGATCCGCAACGCCCTGGCCAGCCCCGGCAGCGGCGGCGACCT
GGGCGAAGCGATCCGCGAGCAGCCGGAGCAGGCCCGTCTGGCCCTGACCCTGGCCGCCGCCGAGAGCGAG
CGCTTCGTCCGGCAGGGCACAGGCAACGACGAGGCCGGCGCGGCCAGCGCCGACGTGGTGAGCCTGACCT
GCCCGGTCGCCGCCGGTGAATGCGCGGGCCCGGCGGACAGCGGCGACGCCCTGCTGGAGCGCAACTATCC
CACTGGCGCGGAGTTCCTCGGCAACGGTGGCGACGTCAGCTTCAGCACCCGCGGCACGCAGAACTGGACG
GTGGAGCGGCTGCTCCAGGCGCACCGCCAACTGGAGGAGCGCGGCTATGTGTTCGTCGGCTACCACGGCA
CCTTCCTCGAAGCGGCGCAAAGCATCGTCTTCGGCGGGGTGCGCGCGCGCAGCCAGGATCTCGACGCGAT
CTGGCGCGGTTTCTATATCGCCGGCGATCCGGAGCTGGCCTACGGCTACGCCCAGGACCAGGAACCCGAC
GCGCGCGGCCGGATCCGCAACGGTGCCCTGCTGCGGGTCTATGTGCCGCGCTCGAGCCTGCCGGGCTTCT
ACCGCACCGGCCTGACCCTGGCCGCGCCGGAGGCGGCGGGCGAGGTCGAACGGCTGATCGGCCATCCGCT
GCCGCTGCGCCTAGACGCCATCACCGGCCCCGAGGAGGAAGGCGGGCGCCTGGAGACCATTCTCGGCTGG
CCGCTGGCCGAGCGCACCGTGGTGATTCCCTCGGCGATCCCCACCGACCCGCGCAACGTCGGCGGCGACC
TCGACCCGTCCAGCATCCCCGACAAGGAACAGGCGATCAGCGCCCTGCCGGACTACGCCAGCCAGCCCGG
CAAACCGCCGCGCGAGGACTTGAAGTA
Protein Sequence 
>gi|218892886|ref|YP_002441755.1| exotoxin A [Pseudomonas aeruginosa LESB58] MHLIPHWIPLVASLGLLAGGSSASAAEEAFDLWNECAKACVLDLKDGVRSSRMSVDPAIADPNGQGVLHYSMVLEGGNDALKLAIDNALSITSDGLTIRLEGGVEPNKPVRYSYTRQARGSWSLNWLVPIGHEKPSNIKVFIHELNAGNQLSHMSPIYTIEMGDELLAKLARDATFFVRAHESNEMQPTLAISHAGVSVVMAQAQPRREKRWSEWASGKVLCLLDPLDGVYNYLAQQRCKLDDTWEGKIYRVLAGNPAKHDLDIKPTVISHRLHFPEGGSLAALTAHQACHLPLETFTRHRQPRGWEQLEQCGYPVQRLVALYLAARLSWNQVDQVIRNALASPGSGGDLGEAIREQPEQARLALTLAAAESERFVRQGTGNDEAGAASADVVSLTCPVAAGECAGPADSGDALLERNYPTGAEFLGNGGDVSFSTRGTQNWTVERLLQAHRQLEERGYVFVGYHGTFLEAAQSIVFGGVRARSQDLDAIWRGFYIAGDPELAYGYAQDQEPDARGRIRNGALLRVYVPRSSLPGFYRTGLTLAAPEAAGEVERLIGHPLPLRLDAITGPEEEGGRLETILGWPLAERTVVIPSAIPTDPRNVGGDLDPSSIPDKEQAISALPDYASQPGKPPREDLK
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: toxA (exotoxin A) blocks protein synthesis by ADP ribosylation of elongation factor 2, thereby triggering cell death (Morlon-Guyot et al., 2009).
References
Morlon-Guyot et al., 2009: Morlon-Guyot J, Méré J, Bonhoure A, Beaumelle B. Processing of Pseudomonas aeruginosa exotoxin A is dispensable for cell intoxication. Infection and immunity. 2009; 77(7); 3090-3099. [PubMed: 19380469].