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exoY from Pseudomonas aeruginosa LESB58

Victor ID 4447
Gene Name exoY from Pseudomonas aeruginosa LESB58
Sequence Strain (Species/Organism) Pseudomonas aeruginosa LESB58
NCBI Gene ID 7177486
NCBI Protein GI 218891856
Locus Tag PLES_31341
Protein Accession YP_002440723.1
Other Database IDs UniProtKB-ID: B7V9R6_PSEA8
UniRef100: UniRef100_B7V9R6
UniRef90: UniRef90_B7V9R6
UniRef50: UniRef50_Q02LX8
UniParc: UPI00000C55FB
EMBL: FM209186
EMBL-CDS: CAW27861.1
RefSeq_NT: NC_011770.1
GenomeReviews: FM209186_GR
KEGG: pag:PLES_31341
HOGENOM: HBG189314
OMA: KERRIND
ProtClustDB: CLSK546574
Taxonomy ID 557722
Gene Starting Position 3461027
Gene Ending Position 3462163
Gene Strand (Orientation) +
Protein Name adenylate cyclase ExoY
DNA Sequence 
>gi|218888746:3461027-3462163 Pseudomonas aeruginosa LESB58, complete genome
CATGCGTATCGACGGTCATCGTCAGGTGGTTTCTAACGCAACGGCACAGCCCGGACCGCTACTGCGCCCT
GCGGATATGCAGGCACGGGCTCTACAGGACCTGTTCGATGCGCAGGGGGTGGGGGTTCCCGTCGAACATG
CCTTGCGCATGCAGGCGGTGGCCAGGCAGACGAATACCGTCTTTGGCATTCGCCCGGTTGAAAGAATCGT
CACCACGCTGATCGAAGAGGGTTTCCCGACCAAGGGCTTCTCGGTGAAGGGGAAAAGCTCGAACTGGGGT
CCGCAGGCGGGGTTCATCTGTGTCGACCAGCATCTCAGCAAGCGGGAAGACCGCGACACGGCGGAAATAC
GCAAGCTGAACCTGGCTGTGGCGAAGGGAATGGATGGCGGAGCCTATACCCAGACCGACCTGCGGATCTC
TCGGCAACGCCTTGCGGAGCTGGTGCGGAATTTCGGCCTGGTGGCAGACGGTGTCGGGCCGGTTCGCCTC
CTGACCGCGCAGGGCCCCAGCGGCAAACGCTATGAGTTCGAGGCCCGCCAGGAGCCGGACGGTCTCTACA
GGATCAGCCGCCTGGGGCGGTCGGAAGCGGTGCAGGTACTGGCCAGCCCGGCTTGCGGGCTGGCGATGAC
CGCCGATTATGACCTCTTCCTGGTAGCGCCCTCGATCGAGGCGCATGGCAGTGGTGGTCTCGATGCAAGA
AGGAATACCGCGGTCAGATACACCCCCCTCGGTGCAAAGGATCCCCTGAGCGAGGACGGATTCTATGGCA
GGGAGGATATGGCCAGGGGAAACATCACTCCGCGCACGCGGCAACTGGTGGACGCCCTCAATGACTGCCT
GGGCCGGGGGGAGCACAGGGAGATGTTTCACCACAGCGACGATGCGGGCAACCCAGGCTCCCATATGGGT
GACAACTTCCCGGCCACCTTCTACCTTCCCCGGGCCATGGAGCATCGGGTCGGAGAAGAGTCCGTTCGCT
TCGACGAGGTCTGCGTGGTGGCGGATCGGAAGAGCTTTTCCTTGCTGGTCGAGTGCATCAAGGGCAACGG
CTATCACTTCACCGCCCATCCCGACTGGAACGTGCCGCTGCGGCCCAGCTTCCAGGAGGCGCTCGACTTT
TTCCAACGTAAGGTCTG
Protein Sequence 
>gi|218891856|ref|YP_002440723.1| adenylate cyclase ExoY [Pseudomonas aeruginosa LESB58] MRIDGHRQVVSNATAQPGPLLRPADMQARALQDLFDAQGVGVPVEHALRMQAVARQTNTVFGIRPVERIVTTLIEEGFPTKGFSVKGKSSNWGPQAGFICVDQHLSKREDRDTAEIRKLNLAVAKGMDGGAYTQTDLRISRQRLAELVRNFGLVADGVGPVRLLTAQGPSGKRYEFEARQEPDGLYRISRLGRSEAVQVLASPACGLAMTADYDLFLVAPSIEAHGSGGLDARRNTAVRYTPLGAKDPLSEDGFYGREDMARGNITPRTRQLVDALNDCLGRGEHREMFHHSDDAGNPGSHMGDNFPATFYLPRAMEHRVGEESVRFDEVCVVADRKSFSLLVECIKGNGYHFTAHPDWNVPLRPSFQEALDFFQRKV
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: exoY is an adenylate cyclase that causes actin disruption in epithelial cells (Cowell et al., 2005).
References
Cowell et al., 2005: Cowell BA, Evans DJ, Fleiszig SM. Actin cytoskeleton disruption by ExoY and its effects on Pseudomonas aeruginosa invasion. FEMS microbiology letters. 2005; 250(1); 71-76. [PubMed: 16039071].