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exoT from Pseudomonas aeruginosa LESB58

Victor ID 4446
Gene Name exoT from Pseudomonas aeruginosa LESB58
Sequence Strain (Species/Organism) Pseudomonas aeruginosa LESB58
NCBI Gene ID 7175181
NCBI Protein GI 218888792
Locus Tag PLES_00451
Protein Accession YP_002437656.1
Other Database IDs UniProtKB-ID: B7V0T1_PSEA8
UniRef100: UniRef100_B7V0T1
UniRef90: UniRef90_B7V0T1
UniRef50: UniRef50_Q93Q17
UniParc: UPI000188F9F4
EMBL: FM209186
EMBL-CDS: CAW24773.1
RefSeq_NT: NC_011770.1
GenomeReviews: FM209186_GR
KEGG: pag:PLES_00451
HOGENOM: HBG298842
OMA: TNGEYQH
ProtClustDB: CLSK689870
Taxonomy ID 557722
Gene Starting Position 58591
Gene Ending Position 59964
Gene Strand (Orientation) +
Protein Name exoenzyme T
DNA Sequence 
>gi|218888746:58591-59964 Pseudomonas aeruginosa LESB58, complete genome
CATGCATATTCAATCATCTCAGCAGAACCCGTCTTTCGTGGCTGAGTTGAGCCAGGCCGTGGCCGGGCGC
CTGGGACAGGTCGAGGCCCGCCAGGTGGCCACTCCCCGGGAGGCGCAACAACTGGCCCAGCGCCAGGAAG
CACCGAAGGGCGAGGGCCTGCTCTCCCGCCTGGGGGCCGCCCTCGCGCGTCCCTTCGTGGCGATCATCGA
GTGGCTGGGCAAACTGCTGGGGAGCCGTGCCCACGCCTCCACCCAGGCGCCGCTCTCCCGTCAGGACGCG
CCGCCTGCCGCCAGTCTCTCGGCCGCCGAGATCAAGCAGATGATGCTGCAAAAGGCACTGCCCCTGACCT
TGGGCGGACTTGGCAAGGCGAGCGAGCTGGCGACTTTGACAGCGGAGAGGCTGGTGAAGGATCACACGCG
CCTGGCCAGCGGCGACGGCGCCCTGCGCTCGCTGGCCACCGCCCTGGTCGGGATTCGCGATGGCAGCCGG
ATCGAGGCTTCCCGTACCCAGGCTGCCCGCCTGCTCGAACAGAGCGTTGGGGGGATCGCGCTGCAACAGT
GGGGGACCGCGGGCGGTGCCGCCAGCCAGCATGTACTCAGCGCAAGCCCGGAGCAGCTGCGCGAAATCGC
CGTCCAACTGCATGCGGCAATGGACAAGGTCGCCCTGTTGCGCCACGCGGTAGAGAGCGAGGTAAAGGGC
GAGCCTGTCGACAAGGCGCTGGCGGATGGCTTGGTGGAGCACTTCGGGCTGGAGGCGGAGCAGTACCTCG
GCGAACACCCGGACGGGCCGTACAGCGATGCCGAGGTGATGGCGCTCGGTCTCTATACCAACGGCGAGTA
CCAGCACCTGAATCGTTCCCTGCGTCAGGGACGGGAGCTGGATGCGGGCCAGGCGTTGATCGACCGGGGC
ATGTCTGCCGCGTTCGAAAAGAGCGGACCGGCTGAACAGGTCGTGAAGACCTTCCGCGGCACCCAGGGCA
GGGATGCCTTCGAGGCGGTGAAAGAGGGCCAGGTCGGCCACGACGCCGGCTATCTCTCCACCTCCCGGGA
CCCCGGCGTTGCCAGGAGCTTCGCGGGCCAGGGCACGATAACCACCCTGTTCGGCAGATCCGGGATCGAT
GTCAGCGAGATATCGATCGAGGGCGATGAGCAGGAGATCCTCTACGACAAGGGGACCGACATGCGCGTAC
TGCTCAGCGCCAAGGATGGGCAGGGTGTGACCCGTCGGGTGCTCGAAGAGGCCACGCTGGGGGAACGGAG
CGGCCACGGCGAGGGACTGCTCGATGCCCTGGACCTGGCAACCGGGACGGATCGTTCAGGCAAGCCCCAG
GAACAGGACCTGCGCCTGAGAATGCGCGGCCTCGACCTGGCCTG
Protein Sequence 
>gi|218888792|ref|YP_002437656.1| exoenzyme T [Pseudomonas aeruginosa LESB58] MHIQSSQQNPSFVAELSQAVAGRLGQVEARQVATPREAQQLAQRQEAPKGEGLLSRLGAALARPFVAIIEWLGKLLGSRAHASTQAPLSRQDAPPAASLSAAEIKQMMLQKALPLTLGGLGKASELATLTAERLVKDHTRLASGDGALRSLATALVGIRDGSRIEASRTQAARLLEQSVGGIALQQWGTAGGAASQHVLSASPEQLREIAVQLHAAMDKVALLRHAVESEVKGEPVDKALADGLVEHFGLEAEQYLGEHPDGPYSDAEVMALGLYTNGEYQHLNRSLRQGRELDAGQALIDRGMSAAFEKSGPAEQVVKTFRGTQGRDAFEAVKEGQVGHDAGYLSTSRDPGVARSFAGQGTITTLFGRSGIDVSEISIEGDEQEILYDKGTDMRVLLSAKDGQGVTRRVLEEATLGERSGHGEGLLDALDLATGTDRSGKPQEQDLRLRMRGLDLA
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: exoT interferes with Rho signal transduction pathways, which regulate actin organization, exocytosis, cell cycle progression, and phagocytosis (Krall et al., 2000).
COG COG5585T, under T: Signal transduction mechanisms
References
Krall et al., 2000: Krall R, Schmidt G, Aktories K, Barbieri JT. Pseudomonas aeruginosa ExoT is a Rho GTPase-activating protein. Infection and immunity. 2000; 68(10); 6066-6068. [PubMed: 10992524].