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exoY from Pseudomonas aeruginosa UCBPP-PA14

Victor ID 4422
Gene Name exoY from Pseudomonas aeruginosa UCBPP-PA14
Sequence Strain (Species/Organism) Pseudomonas aeruginosa UCBPP-PA14
NCBI Gene ID 4384258
NCBI Protein GI 116054461
Locus Tag PA14_36345
Protein Accession YP_791058.1
Other Database IDs UniProtKB-ID: Q02LX8_PSEAB
UniRef100: UniRef100_Q02LX8
UniRef90: UniRef90_Q02LX8
UniRef50: UniRef50_Q02LX8
UniParc: UPI0000E44AAF
EMBL: CP000438
EMBL-CDS: ABJ15697.1
RefSeq_NT: NC_008463.1
GenomeReviews: CP000438_GR
KEGG: pau:PA14_36345
NMPDR: fig|208963.3.peg.3780
eggNOG: NOG146287
HOGENOM: HBG189314
OMA: KERRIND
ProtClustDB: CLSK546574
BioCyc: PAER208963:PA14_36345-MONOMER
Taxonomy ID 208963
Gene Starting Position 3236743
Gene Ending Position 3237987
Gene Strand (Orientation) +
Protein Name adenylate cyclase ExoY
DNA Sequence 
>gi|116048575:3236743-3237987 Pseudomonas aeruginosa UCBPP-PA14, complete genome
CATGCGTATCGACGGTCATCGTCAGGTGGTTTCTAACGCAACGGCACAGCCCGGACCGCTACTGCGCCCT
GCGGATATGCAGGCACGGGCTCTACAGGACCTGTTCGATGCGCAGGGGGTGGGGGTTCCCGTCGAACATG
CCTTGCGCATGCAGGCGGTGGCCAGGCAGACGAATACCGTCTTTGGCATTCGCCCGGTTGAAAGAATCGT
CACTACGCTGATCGAAGAGGGTTTCCCGACCAAGGGCTTCTCGGTGAAGGGGAAAAGCTCGAACTGGGGT
CCGCAGGCGGGGTTCATCTGTGTCGACCAGCATCTCAGCAAGCGGGAAAACCGCGACACGGCGGAAATAC
GCAAGCTGAACCTGGCTGTGGCGAAGGGAATGGATGGCGGAGCCTATACCCAGACCGACCTGCGTATCTC
TCAGCAACGCCTTGCGGAGCTGGTGCGGAATTTCGGCCTGGTGGCAGACGGTGTCGGGCCGGTTCGCCTC
CTGACCGCGCAGGGCCCCAGCGGTAAACGCTATGAGTTCGAGGCCCGCCAGGAGCCGGACGGTCTCTACA
GGATCAGCCGCCTGGGGCGGTCGGAAGCGGTGCAGGTACTGGCCAGCCCGGCTTGCGGGCTGGCGATGAC
CGCCGATTATGACCTCTTCCTGGTAGCGCCCTCGATCGAGGCGCATGGCAATGGTGGTCTCGATGCAAGA
AGGAATACCGCGGTCAGATACACCCCCCTCGGTGCAAAGGATCCCCTGAGCGAGGACGGATTCTATGGCA
GGGAGGATATGGCCAGGGGAAACATCACTCCGCGCACGCGGCAACTGGTGGACGCCCTCAATGACTGCCT
GGGCCGGGGGGAGCACAGGGAGATGTTTCACCACAGCGACGATGCGGGCAACCCAGGCTCCCATATGGGT
GACAACTTCCCGGCCACCTTCTACCTTCCCCGGGCCATGGAGCATCGGCTCGGAGAAGAGTCCGTTCGCT
TCGATGAGGTCTGCGTGGTGGCGGATCGGAAGAGCTTTTCCTTGCTGGTCGAGTGCATCAAGGGCAACGG
CTATCACTTCACCGCCCATCCCGACTGGAACGTGCCGCTGCGGCCCAGCTTCCAGGAGGCGCTCGACTTT
TCCAACGTAAGGTCTGATGCGCGAAGGTCGTTGGCAAAGCCCGCTTTCCCCGGCGGCATGGGCATCCTGC
CGCCTGTCCAAGGCCTTCCGCTTGCCGGAATATGCTGGGCGGCGCGGGGAAGCTA
Protein Sequence 
>gi|116054461|ref|YP_791058.1| adenylate cyclase [Pseudomonas aeruginosa UCBPP-PA14] MRIDGHRQVVSNATAQPGPLLRPADMQARALQDLFDAQGVGVPVEHALRMQAVARQTNTVFGIRPVERIVTTLIEEGFPTKGFSVKGKSSNWGPQAGFICVDQHLSKRENRDTAEIRKLNLAVAKGMDGGAYTQTDLRISQQRLAELVRNFGLVADGVGPVRLLTAQGPSGKRYEFEARQEPDGLYRISRLGRSEAVQVLASPACGLAMTADYDLFLVAPSIEAHGNGGLDARRNTAVRYTPLGAKDPLSEDGFYGREDMARGNITPRTRQLVDALNDCLGRGEHREMFHHSDDAGNPGSHMGDNFPATFYLPRAMEHRLGEESVRFDEVCVVADRKSFSLLVECIKGNGYHFTAHPDWNVPLRPSFQEALDFSNVRSDARRSLAKPAFPGGMGILPPVQGLPLAGICWAARGS
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: exoY is an adenylate cyclase that causes actin disruption in epithelial cells (Cowell et al., 2005).
References
Cowell et al., 2005: Cowell BA, Evans DJ, Fleiszig SM. Actin cytoskeleton disruption by ExoY and its effects on Pseudomonas aeruginosa invasion. FEMS microbiology letters. 2005; 250(1); 71-76. [PubMed: 16039071].