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purL

Victor ID 4233
Gene Name purL
Sequence Strain (Species/Organism) Pseudomonas aeruginosa PAO1
NCBI Gene ID 879752
NCBI Protein GI 15598958
Locus Tag PA3763
Protein Accession NP_252452.1
Other Database IDs UniProtKB-ID: PUR4_PSEAE
UniRef100: UniRef100_Q9HXN2
UniRef90: UniRef90_Q9HXN2
UniRef50: UniRef50_Q1R8H7
UniParc: UPI0000132A5B
EMBL: AE004091
EMBL-CDS: AAG07150.1
RefSeq_NT: NC_002516.2
GenomeReviews: AE004091_GR
KEGG: pae:PA3763
NMPDR: fig|208964.1.peg.3762
PseudoCAP: PA3763
HOGENOM: HBG335309
OMA: ERGIAYY
ProtClustDB: PRK05297
BioCyc: PAER208964:PA3763-MONOMER
Taxonomy ID 208964
Gene Starting Position 4215543
Gene Ending Position 4219439
Gene Strand (Orientation) -
Protein Name phosphoribosylformylglycinamidine synthase
DNA Sequence 
>gi|110645304:4215543-4219439 Pseudomonas aeruginosa PAO1 chromosome, complete genome
ATCAGTCCACCCAGACCCGGGCGTTGCGGAACATGCGCAGCCAGCCGCCGTCTTCCTGCCAGTCGTCCGG
ACGCCAGGAATTCTGCACGGCGCGGAACACCCGCTCGGGGTGCGGCATCATGATGGTGACCCGGCCGTCG
CGGCTGCTCAGCCCGGTGATGCCGCGCGGCGACCCGTTGGGGTTGGCCGGGTAGGCTTCGGTGACCTTGC
CGTGGTTGTCGACGAAACGCAGCGACACGCAGCCGGAAAGGTCGGCCTCGAGCAACGCTTCCTCCGACTC
GAACTCCGCATGGCCTTCGCCATGGGCGATGGCGATCGGCAGGCGCGAACCGGCCATGCCCTGCAGGAAG
ATCGACGACGACTCCTGCACCTGGACCATCGCCACCCGCGCCTCGAACTGCTCGGAACGGTTGCGCACGA
AGTGCGGCCAGAACTCGGTGCCGGGAATCAGCTCGTGCAGGTTGGACATCATCTGGCAGCCGTTGCAGAC
GCCGAGGGCGAAGCTGTCCTTGCGCGCGAAGAACGCCTGGAAGCCGTCGCGGGCGCGGGCGTTGAAGAGG
ATCGACTTGGCCCAGCCCTCGCCGGCGCCGAGCACGTCGCCGTAGGAGAAGCCACCGCAGGCCACCAGGC
CCTTGAAGGCGTCCAGGTCGACCCGCCCGGCGAGGATGTCGCTCATGTGCACGTCGATCGCGGCGAAGCC
GGCGCGGTCGAACGCCGCGGCCATCTCCACCTGGCCGTTGACGCCCTGCTCGCGGAGGATCGCCACTTTC
GGCCGCACGCCCTTCTTGATGTAGGGCGCGGCGATGTCGTCGTTGACGTCGTAGCTGAGCTTGATCGACA
GCCCGGGGTTGTCTTCGTCCAGCAGCGCGTCGAACTCCTGCTCGGCGCAGTCGGCGTTGTCGCGCAGACG
CTGGATCTGGTAGCTGGTCTCGCTCCAGATGCGTTGCAGGATGCGGCGCTGGGCGCTGTAGACGGTCTCG
CCGTTGTAGTTCAGGTTGATCTCGTAGCCGTTGACCGGCTGGCCGATCACCGCCACGCAGTCGTCGAGAC
CGGCGGCGCTGAACTGCGCGAGGACTTCCGGAGTGGCACCCTCGCGAACCTGGATCACCGCGCCCAGTTC
CTCGCTGAACAACACGGCCGCCAGCTCTTCGCGGCTATCGGCCAGGGCATCGAGGTTCAGCTCGACGCCG
CAGTGACCGGCGAAGGCCATCTCCAGCACGCTGGTGATCAGGCCGCCGTCGGAACGGTCGTGGTAGGCGA
GGATATGGCCGTCGGCATTGAGCCCCTGGATCACCGCGAAGAAGGCTTTCAGGTCCTCGGCGTCGTCGAC
GTCCGGCACGGCGCGGCCGAGCTTGCCGTGGACCTGGGCCAGGATCGAGCCGCCGAGACGGTTCTTGCCG
CGGCCGAGATCGATCAGGATCAGGTCGGTCTCGCCCTTGTCCAGGCGCAGTTGCGGGGTCAGGCTCTGGC
GCACGTCGGCGACCGGGGCGAAGCCGGTGACGATCAGCGAGACCGGAGAAGTGACGCTCTTGTCCTCGCC
ATTGTCCTGCCAGCGGGTCTTCATGGACATCGAGTCCTTGCCCACCGGGATGGTGATGCCCAGTTCCGGG
CACAGTTCCATGCCCACGGCCTTGACCGTGTCATACAGGCGCGCGTCCTCGCCGGGGTGGCCGGCGGCGG
CCATCCAGTTGGCGGAAAGCTTGATGTCGGACAGCTTGCCGACACGCGCGGCAGCCAGGTTGGTGACCGT
CTCGCCGATGGCCATGCGTCCGGAAGCCGGGGCGTCCAGCAGCGCCAGCGGGGTACGCTCGCCCATCGCC
ATGGCCTCGCCGGTGTAGACGTCGAAGCTGGTGGCGGTGACGGCGCAGTCGGCCACCGGCACCTGCCAGG
GCCCGACCATCTGGTCGCGGGCCACCAGCCCGGTGATGGTGCGGTCGCCGATGGTGATCAGGAAGCTCTT
GCTGGCCACGGCGGGATGGCGCAGGACGCGCTCGACGCTTTCCTGCAGCTCCAGCCCGGCGGCGTCGAAA
TCGTCGCCCAGCTCGGCCTCGCGGGTGACCGCGCGGTGCATGCGCGGCGCCTTGCCGAGCAGGACTTCCA
GCGGCATGTCCACCGGCTTGTTGTCGAAATGGCTGTCGGCGACGGTCAGCTGGCGCTGCTCGATGGCCTC
GCCGACCACCGCGAACGGGCAGCGCTCGCGCTCGCAGATGGCCTTGAAGGTCTCGAAGTCGGCGGCGTCC
ACCGACAGCACGTAGCGCTCCTGCGACTCGTTGCACCAGATTTCCAGCGGGCTCATGCCCGGCTCGTCGT
TGGGCACCGCGCGCAGCTCGAAGCGACCGCCGCGGCCGCCGTCGTTGATCAGTTCCGGCAGGGCGTTGGA
CAGGCCGCCGGCACCGACGTCATGGATGAAGCTGATCGGGTTGCGCTCGCCGAGCTGCCAGCAGCGGTCG
ATCACTTCCTGGCAACGTCGCTCCATTTCCGGGTTGTCGCGCTGCACCGAGGCGAAGTCGAGGTCGGCGG
AGCTGGCGCCGGTGGCCATCGAAGAGGCGGCGCCGCCGCCCAGGCCGATCAGCATGGCCGGGCCGCCAAG
GACGATGAGCTTGGCGCCGACGCTGATCTCGCCCTTCTGCACGTGTTCGTCGCGAATGTTGCCCATGCCG
CCGGCGAGCATGATCGGCTTGTGGTAGCCGCGCACTTCCTCGCCGTGAGGGGTAGCGATCTTCTGCTCGA
AGGTACGGAAGTAGCCGGTCAGCGCCGGACGGCCGAACTCGTTGTTGAACGCGGCGCCGCCCAGCGGGCC
CTCGACCATGATGTCCAGCGCGGTGACGATGCGCTCGGGCTTGCCGTAGGGCACTTCCCAGGGCTGTTCG
AAACCGGGGATCTGCAGGTTGGACACGGTGAAGCCGGTCAGGCCGGCCTTCGGCTTGGCGCCGCGGCCGG
TGGCGCCCTCGTCGCGGATCTCGCCGCCGGAACCGGTGGAGGCACCGGGGAACGGCGCGATGGCGGTCGG
GTGGTTGTGGGTCTCCACCTTCATCAGGATCTGCACCGGCTCGCGGCTGGCGGCGTATTCGCGGGTCTGC
GGATCGGGGAAGAAACGCCCGGCGACATGGCCGACGATGACCGCGGCGTTGTCCTTGTATGCGGACAGCA
CGCCTTCGCGGTTCATCTCGTAGGTGTTCTTGATCATGCCGAACAGGCTCTTGTCCTGGGCCTGCCCGTC
GATGTCCCAACTGGCATTGAAGATCTTGTGCCGGCAATGCTCGGAGTTGGCCTGGGCGAACATCATCAGC
TCGACGTCGTGCGGGTTGCGCCCCAGTTCGCCGAAGCTCTTCAGCAGGTAGTCGATCTCGTCCTCGGCCA
GGGCCAGGCCCAACTCGACGTTGGCCTTCTCCAGCGCGGCGCGACCGCCGCCAAGCACGTCGACGGCGGT
GAGCGGGCGGGGCTGCGCATGGCTGAACAGCTCGGCGGCGCCTTCCAGGCGGTCCAGCACCAGTTGGGTC
ATGCGGTCATGCAGGCGGGCGGCGACCTGCTGGGCGTCGCTCTCGGACAGTTCGCCCTGCACATAGTAGG
CAATGCCGCGCTCCAGCCGGTCGATCTTCGCCAGGCCGCAGTTGCGGGCGATGTCGGAGGCCTTGCTCGA
CCACGGCGAGATGGTGCCGAAGCGCGGCACCACCAGGAACAGCCGTCCGCTGGGCTCCTGCACCGGCACG
CTCGGGCCGTATTTCAGCAGCCGCGCCAGCACCTGCTCCTCGTCGGCGGTGAGCGCGCCGGTGACGTCGG
CGAAATGCGCGAACTCAGCGTACAGCCCGGTAACGGCAGGTACGTGCTGGGTCAGTTGCTCGAGCAGTTT
GCCGTGGCGGAAAGCGGAAAGGGCGGGAGCGCCGCGCAGGATCAGCA
Protein Sequence 
>gi|15598958|ref|NP_252452.1| phosphoribosylformylglycinamidine synthase [Pseudomonas aeruginosa PAO1] MLILRGAPALSAFRHGKLLEQLTQHVPAVTGLYAEFAHFADVTGALTADEEQVLARLLKYGPSVPVQEPSGRLFLVVPRFGTISPWSSKASDIARNCGLAKIDRLERGIAYYVQGELSESDAQQVAARLHDRMTQLVLDRLEGAAELFSHAQPRPLTAVDVLGGGRAALEKANVELGLALAEDEIDYLLKSFGELGRNPHDVELMMFAQANSEHCRHKIFNASWDIDGQAQDKSLFGMIKNTYEMNREGVLSAYKDNAAVIVGHVAGRFFPDPQTREYAASREPVQILMKVETHNHPTAIAPFPGASTGSGGEIRDEGATGRGAKPKAGLTGFTVSNLQIPGFEQPWEVPYGKPERIVTALDIMVEGPLGGAAFNNEFGRPALTGYFRTFEQKIATPHGEEVRGYHKPIMLAGGMGNIRDEHVQKGEISVGAKLIVLGGPAMLIGLGGGAASSMATGASSADLDFASVQRDNPEMERRCQEVIDRCWQLGERNPISFIHDVGAGGLSNALPELINDGGRGGRFELRAVPNDEPGMSPLEIWCNESQERYVLSVDAADFETFKAICERERCPFAVVGEAIEQRQLTVADSHFDNKPVDMPLEVLLGKAPRMHRAVTREAELGDDFDAAGLELQESVERVLRHPAVASKSFLITIGDRTITGLVARDQMVGPWQVPVADCAVTATSFDVYTGEAMAMGERTPLALLDAPASGRMAIGETVTNLAAARVGKLSDIKLSANWMAAAGHPGEDARLYDTVKAVGMELCPELGITIPVGKDSMSMKTRWQDNGEDKSVTSPVSLIVTGFAPVADVRQSLTPQLRLDKGETDLILIDLGRGKNRLGGSILAQVHGKLGRAVPDVDDAEDLKAFFAVIQGLNADGHILAYHDRSDGGLITSVLEMAFAGHCGVELNLDALADSREELAAVLFSEELGAVIQVREGATPEVLAQFSAAGLDDCVAVIGQPVNGYEINLNYNGETVYSAQRRILQRIWSETSYQIQRLRDNADCAEQEFDALLDEDNPGLSIKLSYDVNDDIAAPYIKKGVRPKVAILREQGVNGQVEMAAAFDRAGFAAIDVHMSDILAGRVDLDAFKGLVACGGFSYGDVLGAGEGWAKSILFNARARDGFQAFFARKDSFALGVCNGCQMMSNLHELIPGTEFWPHFVRNRSEQFEARVAMVQVQESSSIFLQGMAGSRLPIAIAHGEGHAEFESEEALLEADLSGCVSLRFVDNHGKVTEAYPANPNGSPRGITGLSSRDGRVTIMMPHPERVFRAVQNSWRPDDWQEDGGWLRMFRNARVWVD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purL mutant is attenuated in rats (Potvin et al., 2003).
COG COG0046F, under F: Nucleotide transport and metabolism
References
Potvin et al., 2003: Potvin E, Lehoux DE, Kukavica-Ibrulj I, Richard KL, Sanschagrin F, Lau GW, Levesque RC. In vivo functional genomics of Pseudomonas aeruginosa for high-throughput screening of new virulence factors and antibacterial targets. Environmental microbiology. 2003; 5(12); 1294-1308. [PubMed: 14641575].