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exoY from Pseudomonas aeruginosa PAO1

Victor ID 4230
Gene Name exoY from Pseudomonas aeruginosa PAO1
Sequence Strain (Species/Organism) Pseudomonas aeruginosa PAO1
NCBI Gene ID 879421
NCBI Protein GI 15597387
Locus Tag PA2191
Protein Accession NP_250881.1
Other Database IDs UniProtKB-ID: Q9I1S4_PSEAE
UniRef100: UniRef100_B7V9R6
UniRef90: UniRef90_B7V9R6
UniRef50: UniRef50_Q02LX8
UniParc: UPI00000C55FB
EMBL: AE004091
EMBL-CDS: AAG05579.1
RefSeq_NT: NC_002516.2
HSSP: P40136
GenomeReviews: AE004091_GR
KEGG: pae:PA2191
NMPDR: fig|208964.1.peg.2191
PseudoCAP: PA2191
HOGENOM: HBG189314
OMA: KERRIND
ProtClustDB: CLSK546574
BioCyc: PAER208964:PA2191-MONOMER
Taxonomy ID 208964
Gene Starting Position 2410343
Gene Ending Position 2411479
Gene Strand (Orientation) -
Protein Name adenylate cyclase ExoY
DNA Sequence 
>gi|110645304:2410343-2411479 Pseudomonas aeruginosa PAO1 chromosome, complete genome
ATCAGACCTTACGTTGGAAAAAGTCGAGCGCCTCCTGGAAGCTGGGCCGCAGCGGCACGTTCCAGTCGGG
ATGGGCGGTGAAGTGATAGCCGTTGCCCTTGATGCACTCGACCAGCAAGGAAAAGCTCTTCCGATCCGCC
ACCACGCAGACCTCGTCGAAGCGAACGGACTCTTCTCCGACCCGATGCTCCATGGCCCGGGGAAGGTAGA
AGGTGGCCGGGAAGTTGTCACCCATATGGGAGCCTGGGTTGCCCGCATCGTCGCTGTGGTGAAACATCTC
CCTGTGCTCCCCCCGGCCCAGGCAGTCATTGAGGGCGTCCACCAGTTGCCGCGTGCGCGGAGTGATGTTT
CCCCTGGCCATATCCTCCCTGCCATAGAATCCGTCCTCGCTCAGGGGATCCTTTGCACCGAGGGGGGTGT
ATCTGACCGCGGTATTCCTTCTTGCATCGAGACCACCACTGCCATGCGCCTCGATCGAGGGCGCTACCAG
GAAGAGGTCATAATCGGCGGTCATCGCCAGCCCGCAAGCCGGGCTGGCCAGTACCTGCACCGCTTCCGAC
CGCCCCAGGCGGCTGATCCTGTAGAGACCGTCCGGCTCCTGGCGGGCTTCGAACTCATAGCGTTTGCCGC
TGGGGCCCTGCGCGGTCAGGAGGCGAACCGGCCCGACACCGTCTGCCACCAGGCCGAAATTCCGCACCAG
CTCCGCAAGGCGTTGCCGAGAGATGCGCAGGTCGGTCTGGGTATAGGCTCCGCCATCCATTCCCTTCGCC
ACAGCCAGGTTCAGCTTGCGTATTTCCGCCGTGTCGCGGTCTTCCCGCTTGCTGAGATGCTGGTCGACAC
AGATGAACCCCGCCTGCGGACCCCAGTTCGAGCTTTTCCCCTTCACCGAGAAGCCCTTGGTCGGGAAACC
CTCTTCGATCAGCGTGGTGACGATTCTTTCAACCGGGCGAATGCCAAAGACGGTATTCGTCTGCCTGGCC
ACCGCCTGCATGCGCAAGGCATGTTCGACGGGAACCCCCACCCCCTGCGCATCGAACAGGTCCTGTAGAG
CCCGTGCCTGCATATCCGCAGGGCGCAGTAGCGGTCCGGGCTGTGCCGTTGCGTTAGAAACCACCTGACG
ATGACCGTCGATACGCA
Protein Sequence 
>gi|15597387|ref|NP_250881.1| adenylate cyclase [Pseudomonas aeruginosa PAO1] MRIDGHRQVVSNATAQPGPLLRPADMQARALQDLFDAQGVGVPVEHALRMQAVARQTNTVFGIRPVERIVTTLIEEGFPTKGFSVKGKSSNWGPQAGFICVDQHLSKREDRDTAEIRKLNLAVAKGMDGGAYTQTDLRISRQRLAELVRNFGLVADGVGPVRLLTAQGPSGKRYEFEARQEPDGLYRISRLGRSEAVQVLASPACGLAMTADYDLFLVAPSIEAHGSGGLDARRNTAVRYTPLGAKDPLSEDGFYGREDMARGNITPRTRQLVDALNDCLGRGEHREMFHHSDDAGNPGSHMGDNFPATFYLPRAMEHRVGEESVRFDEVCVVADRKSFSLLVECIKGNGYHFTAHPDWNVPLRPSFQEALDFFQRKV
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: exoY is an adenylate cyclase that causes actin disruption in epithelial cells (Cowell et al., 2005).
References
Cowell et al., 2005: Cowell BA, Evans DJ, Fleiszig SM. Actin cytoskeleton disruption by ExoY and its effects on Pseudomonas aeruginosa invasion. FEMS microbiology letters. 2005; 250(1); 71-76. [PubMed: 16039071].