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exoT from Pseudomonas aeruginosa PAO1

Victor ID 4219
Gene Name exoT from Pseudomonas aeruginosa PAO1
Sequence Strain (Species/Organism) Pseudomonas aeruginosa PAO1
NCBI Gene ID 878350
NCBI Protein GI 15595242
Locus Tag PA0044
Protein Accession NP_248734.1
Other Database IDs UniProtKB-ID: Q9I788_PSEAE
UniRef100: UniRef100_Q9I788
UniRef90: UniRef90_B7V0T1
UniRef50: UniRef50_Q93Q17
UniParc: UPI00000C4EFE
EMBL: AE004091
EMBL-CDS: AAG03434.1
RefSeq_NT: NC_002516.2
HSSP: Q51451
GenomeReviews: AE004091_GR
KEGG: pae:PA0044
NMPDR: fig|208964.1.peg.44
PseudoCAP: PA0044
HOGENOM: HBG298842
OMA: TNGEYQH
ProtClustDB: CLSK689870
BioCyc: PAER208964:PA0044-MONOMER
Taxonomy ID 208964
Gene Starting Position 58785
Gene Ending Position 60158
Gene Strand (Orientation) +
Protein Name exoenzyme T
DNA Sequence 
>gi|110645304:58785-60158 Pseudomonas aeruginosa PAO1 chromosome, complete genome
CATGCATATTCAATCATCTCAGCAGAACCCGTCTTTCGTGGCTGAGTTGAGCCAGGCCGTGGCCGGGCGC
CTGGGACAGGTCGAGGCCCGCCAGGTGGCCACTCCCCGGGAGGCGCAACAACTGGCCCAGCGCCAGGAAG
CACCGAAGGGCGAGGGCCTGCTCTCCCGCCTGGGGGCTGCCCTCGCGCGTCCCTTCGTGGCGATCATCGA
GTGGCTGGGCAAACTGCTGGGGAGCCGTGCCCACGCCGCCACCCAGGCGCCGCTCTCCCGTCAGGACGCG
CCGCCTGCCGCCAGTCTCTCTGCCGCCGAGATCAAGCAGATGATGCTGCAAAAGGCACTGCCCCTGACCT
TGGGCGGACTTGGCAAGGCGAGCGAGCTGGCGACTTTGACAGCGGAGAGGCTGGCGAAGGATCACACGCG
CCTGGCCAGCGGCGACGGCGCTCTGCGATCGCTGGCCACCGCCCTGGTCGGGATTCGCGATGGCAGCCGG
ATCGAGGCTTCCCGTACCCAGGCTGCCCGCCTGCTCGAACAGAGCGTTGGGGGGATCGCGCTGCAACAGT
GGGGGACCGCGGGCGGTGCCGCCAGCCAGCATGTACTCAGCGCAAGCCCGGAGCAACTGCGCGAAATCGC
CGTCCAACTGCATGCGGTAATGGACAAGGTCGCCCTGTTGCGCCACGCGGTAGAGAGCGAGGTAAAGGGC
GAGCCTGTCGACAAGGCGCTGGCGGATGGCCTGGTGGAGCACTTCGGGCTGGAGGCGGAGCAGTACCTCG
GCGAACACCCGGACGGGCCGTACAGCGATGCCGAGGTGATGGCGCTCGGTCTCTATACCAACGGCGAGTA
CCAGCACCTGAATCGGTCCCTGCGTCAGGGACGGGAGCTGGATGCGGGCCAGGCGTTGATCGACCGGGGC
ATGTCTGCCGCGTTCGAAAAGAGCGGACCGGCTGAACAGGTCGTGAAGACCTTCCGCGGCACCCAGGGCA
GGGATGCCTTCGAGGCGGTGAAAGAGGGCCAGGTCGGCCACGACGCCGGCTATCTCTCCACCTCCCGGGA
CCCCGGCGTTGCCAGGAGCTTCGCGGGCCAGGGCACGATAACCACCCTGTTCGGCAGATCCGGGATCGAT
GTCAGCGAGATATCGATCGAGGGCGATGAGCAGGAGATCCTCTACGACAAGGGGACCGACATGCGCGTGC
TTCTCAGTGCCAAGGATGGGCAGGGTGTGACCCGTCGGGTGCTCGAAGAGGCCACGCTGGGGGAACGGAG
CGGCCACGGCGAGGGACTGCTCGATGCCCTGGACCTGGCAACCGGGACGGATCGTTCAGGCAAGCCCCAG
GAACAGGACCTGCGCCTGAGAATGCGCGGCCTCGACCTGGCCTG
Protein Sequence 
>gi|15595242|ref|NP_248734.1| exoenzyme T [Pseudomonas aeruginosa PAO1] MHIQSSQQNPSFVAELSQAVAGRLGQVEARQVATPREAQQLAQRQEAPKGEGLLSRLGAALARPFVAIIEWLGKLLGSRAHAATQAPLSRQDAPPAASLSAAEIKQMMLQKALPLTLGGLGKASELATLTAERLAKDHTRLASGDGALRSLATALVGIRDGSRIEASRTQAARLLEQSVGGIALQQWGTAGGAASQHVLSASPEQLREIAVQLHAVMDKVALLRHAVESEVKGEPVDKALADGLVEHFGLEAEQYLGEHPDGPYSDAEVMALGLYTNGEYQHLNRSLRQGRELDAGQALIDRGMSAAFEKSGPAEQVVKTFRGTQGRDAFEAVKEGQVGHDAGYLSTSRDPGVARSFAGQGTITTLFGRSGIDVSEISIEGDEQEILYDKGTDMRVLLSAKDGQGVTRRVLEEATLGERSGHGEGLLDALDLATGTDRSGKPQEQDLRLRMRGLDLA
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: exoT interferes with Rho signal transduction pathways, which regulate actin organization, exocytosis, cell cycle progression, and phagocytosis (Krall et al., 2000).
COG COG5585T, under T: Signal transduction mechanisms
References
Krall et al., 2000: Krall R, Schmidt G, Aktories K, Barbieri JT. Pseudomonas aeruginosa ExoT is a Rho GTPase-activating protein. Infection and immunity. 2000; 68(10); 6066-6068. [PubMed: 10992524].