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metE

Victor ID 4203
Gene Name metE
Sequence Strain (Species/Organism) Pseudomonas aeruginosa PAO1
NCBI Gene ID 877662
NCBI Protein GI 15597123
Locus Tag PA1927
Protein Accession NP_250617.1
Other Database IDs UniProtKB-ID: METE_PSEAE
UniRef100: UniRef100_P57703
UniRef90: UniRef90_B7VAU6
UniRef50: UniRef50_B0U3F5
UniParc: UPI000012EF7C
EMBL: AE004091
EMBL-CDS: AAG05315.1
RefSeq_NT: NC_002516.2
GenomeReviews: AE004091_GR
KEGG: pae:PA1927
NMPDR: fig|208964.1.peg.1927
PseudoCAP: PA1927
HOGENOM: HBG287495
OMA: RFGWVQS
ProtClustDB: PRK05222
BioCyc: PAER208964:PA1927-MONOMER
Taxonomy ID 208964
Gene Starting Position 2106579
Gene Ending Position 2108879
Gene Strand (Orientation) +
Protein Name 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
DNA Sequence 
>gi|110645304:2106579-2108879 Pseudomonas aeruginosa PAO1 chromosome, complete genome
CATGGCCCTGGCCCACACTCTCGGCTTCCCACGCATCGGACGCGATCGCGAACTGAAAAAAGCCCAGGAA
GCGTTCTGGAAGGGCGAGCTGGACGAGGCCGGCCTGCGGGCCGTCGGTCGGCAGCTGCGCGCTGCCCACT
GGCAGGTACAGAAGGATGCCGGCATCCAGTTGCTGCCGGTCGGCGATTTCGCCTGGTATGACCAGGTGCT
GACCCATTCGCTGACCTTCGGCGTGATCCCCGAGCGCTTCCGGGCGCACGGCGAGGCCGGGCCGACCCTG
CATACCCTGTTCGGCATGGCCCGTGGCGTCAGCGACGACAGTTGTTGCGGCGGTGCCCATGCCCAGGAAA
TGACCAAGTGGTTCGACACCAACTATCACTACCTGGTCCCCGAGTTCAGCGCCGATCAGCAGTTCCAGCT
GAGCTGGGAACAACTGTTCGAGGAGGTCGACGAGGCCAGGGCCCTCGGCCACCAGGTGAAGCCGGTGCTG
ATCGGTCCGCTGACCTACCTGTGGCTGGGCAAGGCCAAGGGCGCCGAGTTCGACAGGCTCGACCTGCTGG
ACCGCCTGCTGCCGCTCTACGGCCAGATCTTCCGTCGTCTCGCCGGCCAGGGCGTGGAGTGGGTGCAGAT
CGACGAGCCGATCCTGGTCCTCGACCTGCCGCAGGCATGGAAGAATGCCTTCGAGCGCGCCTACAACCTG
CTACAGAGCGAGCCGCTGAAGAAGCTGGTCGCCACCTACTTCGGCGGCCTGGAAGACAACCTGGGCCTGG
CCGCCAACCTCCCGGTGGACGGCCTGCACATCGACCTGGTGCGAGCGCCGGAACAGTATCCGAGCATCCT
CGACCGCCTGCCGGCCTACAAGGTCGTCTCGCTGGGCCTGGTCAACGGGCGCAACGTCTGGCGCTGCGAC
CTGGAGAAAGCCCTGGAGGTGGTGCGCCATGCCCGGGAGCGCCTGGGCGAGCGGCTGTGGGTCGCGCCGT
CCTGCTCGCTGCTGCACAGCCCGGTGGACCTGGAACGCGAAGACGGGCTGGACGCCGAGCTGAAGAGCTG
GCTGGCCTTCGCCGTGCAGAAGTGCCGCGAAGTCGCGGTGCTGGCCCGTGCCGCCACTGAGCCGGAAGCC
GCCGAGGTGCTTGCCGCCCTGGAAGAGAGCCGTGCGGTCCAGGCCAGCCGCGCTTCCTCGCCGCGAATCC
ACAAGCCGGCCGTGCAGGCGCGCCTGGCCGCGATCAAGGCCAGCGACGCCCAGCGTCGCTCGCCGTTCGC
CGAACGCATCGCCAGGCAGCGTGCCGGGCTCGACCTGCCGGCGTTCCCGACCACTACCATCGGCTCTTTC
CCGCAGACCTCGTCGATCCGCCTGGCCCGCCAGTCGTTCAAGCAGGGCAAGCTGAGCGAGGCCGAGTACA
TCGAGGCGATGCACAGCGAGATCCGCCATGCGGTGCAGATCCAGGAACAACTGGGGCTGGACGTGCTGGT
ACATGGCGAAGCCGAGCGCAACGACATGGTCGAGTACTTCGCCGAGCAACTGGACGGCTACGTCTTCACC
CGCTTCGGCTGGGTGCAGAGCTACGGCTCGCGCTGCGTGAAGCCGGCGGTGATCTATGGCGACCTGAGCC
GTCCGCGGGCCATGACCGTGGAGTGGATCAGGTACGCCCAGAGCCTTACCGACAAGGTGATGAAGGGCAT
GCTGACCGGCCCGGTGACCATGCTGATGTGGTCCTTCCCGCGCGAGGACGTGTCTCGCGAGGTGCAGGCG
CGCCAGTTGGCCCTGGCGATCCGCGACGAAGTGGTCGACCTGGAGGCCGCCGGCATCAGGATCGTGCAGA
TCGACGAGGCGGCTTTCCGCGAAGGCCTGCCGCTGCGCCGCAACGCCTGGCCGCACTATCTGGAGTGGGC
CACCGAGGCCTTCCGCCTGTGCGCCTCCGGAGTCCGCGACGAAACCCAGATCCATACGCACATGTGCTAC
AGCGAGTTCAACGATGTGATCGAGTCCATCGCCGCCATGGACGCCGACGTGATCACCATCGAGACCTCGC
GTTCGGACATGGAGCTGCTGGAGGCTTTCGAGCAGTTCGACTACCCGAACGAGATCGGTCCGGGCGTCTA
CGACATCCACTCGCCACGCGTGCCGAGCCGGGAAGAGATCGTCGCGTTGCTGCGCAAGGCGGCCCGGCGG
ATACCCGCCGAGCGGCTCTGGGTCAACCCGGACTGCGGCCTGAAGACCCGCGCCTGGCCGGAAACCGAGG
CAGCGCTGGTGAACATGGTCGCCGCGGCCCGCGAACTGCGTGGCGACCTCGCCCGCGGTTG
Protein Sequence 
>gi|15597123|ref|NP_250617.1| 5-methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase [Pseudomonas aeruginosa PAO1] MALAHTLGFPRIGRDRELKKAQEAFWKGELDEAGLRAVGRQLRAAHWQVQKDAGIQLLPVGDFAWYDQVLTHSLTFGVIPERFRAHGEAGPTLHTLFGMARGVSDDSCCGGAHAQEMTKWFDTNYHYLVPEFSADQQFQLSWEQLFEEVDEARALGHQVKPVLIGPLTYLWLGKAKGAEFDRLDLLDRLLPLYGQIFRRLAGQGVEWVQIDEPILVLDLPQAWKNAFERAYNLLQSEPLKKLVATYFGGLEDNLGLAANLPVDGLHIDLVRAPEQYPSILDRLPAYKVVSLGLVNGRNVWRCDLEKALEVVRHARERLGERLWVAPSCSLLHSPVDLEREDGLDAELKSWLAFAVQKCREVAVLARAATEPEAAEVLAALEESRAVQASRASSPRIHKPAVQARLAAIKASDAQRRSPFAERIARQRAGLDLPAFPTTTIGSFPQTSSIRLARQSFKQGKLSEAEYIEAMHSEIRHAVQIQEQLGLDVLVHGEAERNDMVEYFAEQLDGYVFTRFGWVQSYGSRCVKPAVIYGDLSRPRAMTVEWIRYAQSLTDKVMKGMLTGPVTMLMWSFPREDVSREVQARQLALAIRDEVVDLEAAGIRIVQIDEAAFREGLPLRRNAWPHYLEWATEAFRLCASGVRDETQIHTHMCYSEFNDVIESIAAMDADVITIETSRSDMELLEAFEQFDYPNEIGPGVYDIHSPRVPSREEIVALLRKAARRIPAERLWVNPDCGLKTRAWPETEAALVNMVAAARELRGDLARG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: metE mutant is attenuated in rats (Potvin et al., 2003).
COG COG0620E, under E: Amino acid transport and metabolism
References
Potvin et al., 2003: Potvin E, Lehoux DE, Kukavica-Ibrulj I, Richard KL, Sanschagrin F, Lau GW, Levesque RC. In vivo functional genomics of Pseudomonas aeruginosa for high-throughput screening of new virulence factors and antibacterial targets. Environmental microbiology. 2003; 5(12); 1294-1308. [PubMed: 14641575].