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BB0797

Victor ID 4200
Gene Name BB0797
Sequence Strain (Species/Organism) Borrelia burgdorferi B31
NCBI Gene ID 1195655
NCBI Protein GI 15595142
Locus Tag BB0797
Genbank Accession AE000783
Protein Accession NP_212931
Other Database IDs UniProtKB-ID: MUTS_BORBU
UniRef100: UniRef100_B7J0P3
UniRef90: UniRef90_Q0SM54
UniRef50: UniRef50_Q0SM54
UniParc: UPI00000575FF
EMBL: AE000783
EMBL-CDS: AAC67157.1
RefSeq_NT: NC_001318.1
EnsemblGenome: EBBORG00000008761
EnsemblGenome_TRS: EBBORT00000008762
EnsemblGenome_PRO: EBBORP00000008092
GenomeReviews: AE000783_GR
KEGG: bbu:BB0797
NMPDR: fig|224326.1.peg.1181
TIGR: BB_0797
HOGENOM: HBG735169
OMA: DFFECFF
ProtClustDB: PRK05399
BioCyc: BBUR224326:BB_0797-MONOMER
Taxonomy ID 224326
Gene Starting Position 839243
Gene Ending Position 841831
Gene Strand (Orientation) +
Protein Name DNA mismatch repair protein MutS
Protein pI 6.34
Protein Weight 94686
Protein Length 862
Protein Note This protein performs the mismatch recognition step during the DNA repair process
DNA Sequence 
>gi|15594346:839243-841831 Borrelia burgdorferi B31 chromosome, complete genome
TATGGAAAAAAATGTTACCCCAATGATAAGGCAGTATTTAGATATCAAGAAAAAATATAAAGATGCTGTT
CTTTTTTTCAGAGTAGGAAGTTTTTATGAAATGTTTTTTGATGATGCAATTGAGGTAAGCAAGCTTCTTA
ATTTAACGTTGACAAAAAGAGAAAATGTTCCAATGTGTGGGGTTCCTTATCATACCAGTAAAGAATATAT
AAGGAAATTAATTTTATTTGATAAAAAGGTTGCAATTTGTGAACAAGCGTCCAATTCTACTTCTGGGGGG
CCTTTAGAAAGAGAGGTTGTTGAGGTAATAACCCCAGGCGTTATTATTGATGAAGATTTTTTAAATGATG
ATATTAATAACTATTTAGTTGCTATTAGTGATTATAAAGATTATTATTCGTTTTCTTATATAGATTTATC
TACTTCCAGTCTTGGAATAATGTTTTATGAGAATGGTTTTTTTGAAAAACTTAAAAGGGATCTTGAGAAA
TACTCTCCTAAAGAGATAATAGTTTCTGAAAATTTTTATTATGAATACTCAGAGAAGCTTAATCTTAGTA
GATTTTTAATTAACAGAGTTCCTACTTGGCATCTTGATAAGGATATTGCAATAAAAACAATAAAGGAGCA
TTTTAACATACTTGGATTGAGCTCTCTTGGATTTGATGAGGAAAAGCCCTATTACATTTCAATTTTTCTT
ATTATAAATCATATAAAAAATAATTTAAAAAATTTATTAAGTAATATTGATAAAATAGATATCAATAATG
ATTCTTCGTACATGTTTCTTGATGACGTAACTCAAGTTAATCTTGAACTTGTAAAAAATAATAATGATTT
TTCTTCTCAATATTCATTATATTCTGTGTTAAATGATTGCAAAACTGCAATGGGAAAGAGACTTTTAAGA
GAATTTATTTTAAATCCAATTTTAAATATTTCTGAGATTAATACCAGGCTAGATCATGTTGAATTTTTTT
GCAAAAATATTAGCTTGACTGTGACTTTAAGAGAAACTTTTATTAATATATGGGATATTGAGAGAATAAT
ATCTAGGATTCAAATGAAAAGATATATTAAAAAAGATTTTTTATTTATTGAAAAAGCTCTTTCTGTATTT
TTTACGGTAAAAAAGTTATTTGACAAGCATAATTTTGATTATTGGAATTTTGATAAATTTGAAGAGGATA
GTATTTCTAAAGTTTATTTTTTGATAAATAGTGCAATTTCAAGTGCACCTGATGAACTTATTAAAAGAGG
TTATGACTTAAAGCTTGATAACTTAAAAGATTTAAAGATTAATGCAAATAAATATATTGATCAATATCTT
GAATCAGAGAGATTGCTTAGCAAGATTAATAACCTAAAGATTAGAAAAACTAATAATAGGGGGTTATTTT
TTGAAGTTACAAAGAGTAATTATGCTCAAGTGCCACCACATTTTATGGAAAGCCAAGCTTTAAATTCTTC
AAAAAGATATAAAACAGAAAAACTTATTTCTCTTGAGGTGGATATTAATAATGCTGAAGATAATGTGGTT
GCTTTTGAACAGGAAATTTTTGATGAAATAGCATCAAATGTTGTTATGCATAATAAAGTTCTTAAAAAGG
TTGCAGAATTTTTTGCATATATTGATTTAGTTGTTAACTTTGGTTATTTGGCAAAAAAAAATGAATATAA
AAGGCCTGTATTGACATCTGGTAAAGAAATTCTTCTTGAAAAGTCTCGGCATCCTGTTGTTGAGCACTAC
ACTAAAAATACTGAAATCTTTACTGAAAATTTTGTAAGAATTAATAAAGAAAAGTATTTTTGTTTAATTA
CTGGACCTAATATGGCAGGTAAATCAACCTATTTGCGTCAGGTGGCTTTAATTACTTTAATGGCGCATAT
AGGCTCTTTTGTGCCAGCTTCTAAAGCTTTAATAGGTATTACAGATAAAATTTTTTGCAGGATTGGAGCA
AGTGATAACATTGCCAAAGGGGAATCCACTTTTTTAGTTGAAATGAATGAAACAGCCAACATTTTAAGGA
ATGCAACAGAAAAGAGTTTAATAATTATGGATGAAGTTGGAAGAGGTACTAGCACAAATGATGGGCTTGC
TATTGCTTATTCTATTATAGAGTATATTTTAGAGTATATTAAAGCTAGAAGTTTGTTTGCCACACATTTT
CATGAATTGTCGTCTATTAATCATCAGGCTTTTATTAATCTTTCAATGAAAATTGAAAAGCAGGGCAACG
ATCTTGTTTTCTTAAGAGAAGTTGAAGAAAAGCCATCTCTTAATTCTTATGGTATTTATGTTGCTCGCAT
AGCAGGACTTCCCTTAAGGGTAATAGATAGAGCTAATGTTATTCTAGAAAGTTTGGTGGGCCGAGAGGGC
AACTCTTGTTTAGAGTTTCTTCCCCATGTTTCTTCTGATGGTAATGATAAAGAGATCTTGAAAAATGACA
CTGATATTCATATTAAATTAAATGAGTATTTAGAGTTAAAAAATTTTATTTCTAACATAGATATTAATAA
TATTACTCCTTTTCAATCAATTGAGCTGTTAAATCAAATTGTTTTAAAGGTTATTTCTCAGTCCAGTTA
Protein Sequence 
>gi|15595142|ref|NP_212931.1| DNA mismatch repair protein MutS [Borrelia burgdorferi B31]
MEKNVTPMIRQYLDIKKKYKDAVLFFRVGSFYEMFFDDAIEVSKLLNLTLTKRENVPMCGVPYHTSKEYI
RKLILFDKKVAICEQASNSTSGGPLEREVVEVITPGVIIDEDFLNDDINNYLVAISDYKDYYSFSYIDLS
TSSLGIMFYENGFFEKLKRDLEKYSPKEIIVSENFYYEYSEKLNLSRFLINRVPTWHLDKDIAIKTIKEH
FNILGLSSLGFDEEKPYYISIFLIINHIKNNLKNLLSNIDKIDINNDSSYMFLDDVTQVNLELVKNNNDF
SSQYSLYSVLNDCKTAMGKRLLREFILNPILNISEINTRLDHVEFFCKNISLTVTLRETFINIWDIERII
SRIQMKRYIKKDFLFIEKALSVFFTVKKLFDKHNFDYWNFDKFEEDSISKVYFLINSAISSAPDELIKRG
YDLKLDNLKDLKINANKYIDQYLESERLLSKINNLKIRKTNNRGLFFEVTKSNYAQVPPHFMESQALNSS
KRYKTEKLISLEVDINNAEDNVVAFEQEIFDEIASNVVMHNKVLKKVAEFFAYIDLVVNFGYLAKKNEYK
RPVLTSGKEILLEKSRHPVVEHYTKNTEIFTENFVRINKEKYFCLITGPNMAGKSTYLRQVALITLMAHI
GSFVPASKALIGITDKIFCRIGASDNIAKGESTFLVEMNETANILRNATEKSLIIMDEVGRGTSTNDGLA
IAYSIIEYILEYIKARSLFATHFHELSSINHQAFINLSMKIEKQGNDLVFLREVEEKPSLNSYGIYVARI
AGLPLRVIDRANVILESLVGREGNSCLEFLPHVSSDGNDKEILKNDTDIHIKLNEYLELKNFISNIDINN
ITPFQSIELLNQIVLKVISQSS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mutant showed attenuated virulence in C3H/HeN mice (Lin et al., 2009).
COG COG0249L, under L: Replication, recombination and repair
References
Lin et al., 2009: Lin T, Gao L, Edmondson DG, Jacobs MB, Philipp MT, Norris SJ. Central role of the Holliday junction helicase RuvAB in vlsE recombination and infectivity of Borrelia burgdorferi. PLoS pathogens. 2009; 5(12); e1000679. [PubMed: 19997622].