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BB0098

Victor ID 4192
Gene Name BB0098
Sequence Strain (Species/Organism) Borrelia burgdorferi B31
NCBI Gene ID 1194934
NCBI Protein GI 15594444
Locus Tag BB0098
Genbank Accession AE000783
Protein Accession NP_212232
Other Database IDs UniProtKB-ID: MUTS2_BORBU
UniRef100: UniRef100_O51125
UniRef90: UniRef90_O51125
UniRef50: UniRef50_O51125
UniParc: UPI000005734F
EMBL: AE000783
EMBL-CDS: AAC66481.1
RefSeq_NT: NC_001318.1
EnsemblGenome: EBBORG00000008493
EnsemblGenome_TRS: EBBORT00000008494
EnsemblGenome_PRO: EBBORP00000007824
GenomeReviews: AE000783_GR
KEGG: bbu:BB0098
NMPDR: fig|224326.1.peg.482
TIGR: BB_0098
HOGENOM: HBG354518
OMA: PGLVHDQ
ProtClustDB: CLSK507352
BioCyc: BBUR224326:BB_0098-MONOMER
Taxonomy ID 224326
Gene Starting Position 94610
Gene Ending Position 96952
Gene Strand (Orientation) -
Protein Name recombination and DNA strand exchange inhibitor protein
Protein pI 8.85
Protein Weight 84485.22
Protein Length 780
Protein Note MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange
DNA Sequence 
>gi|15594346:94610-96952 Borrelia burgdorferi B31 chromosome, complete genome
ATTAAATCTCAACTATGGTTTTTCCAGACCCTCCATCACTAGGGTGAGCAAAATAATATTTTCTAATAAA
CTTCAATTCTTTTAATAAATTGTGAACTTCTCTCATAAGATGGCCCTCCCCTTTTCCATGAATGATCTCA
AATTTATTAATACCATTTAATATAATATTATCTATTTTCTTATTCAAAAAGTCTAGAGCATCAACAGACC
TCATACCCCTAATATCAATGGTAAAGCTTAATAAATTTTCCTTATTATAATCAATTGAAAAGTTAAAATT
TTTTCCATTCTCTTTTTTTTCTTTAAAGTTTTCCAAAGATATCTCTGAGCTAGAAACACTAACATTAAAA
GCACCTACATTAACGGTGATCTTCTTTTTTGAGATCCCGACTATTTTTCCTTTTGCATTAGAATTAACTA
TTCTAACCTTGTCTCCTATTTTAAAATCTGCAACTACATTTCTCTTATTGTTAAGAGAATTCACTTTATT
TGTCTTGAGGTCTACATTTTTTTCCAAATCTGATATAAAAGCTTTATTCTTTGCAACATTAATATTGCCC
TCTTTTATTTCTCTAACCAAATTTTCTAAAACTTTTCTTGAATTTTTTAAAAATTCATTCTGCTCATTTA
AAAGCTTTGTCTCAATATTTTTTTCCCTTAATAAAAGATCTTGATAAAAATTTTCTAGCTCTTTTTCTTG
CAATTCTATTTGGATTAATTTCTTATCCATACTTTCTTTAATTAAAAGCAAATCTTTTTCTTTTTCTATT
AATTTTTCTAAAATTTCATTAATTTCTGTTTTTTGAGATGAATAAATTTCATTAGCACGAATTACTATGC
TCCTGTCAATCAAAGCCTTGCTAGCAACATTAAACGCATAACTTTCACCAGGAATGGAAAAAATTAAATT
ATAATTGGGCTGCATTGTCTCTAAATCCATCCGCATAGAAGCATTAACAACACCTTCATGGGTATATGCA
AAATATTTAAGAGCATTATAATGAGTTGATATTAAAACATAAGAATTAATATTGATCAAATATTCAAGAA
TTGAAATAGCAAGCGCCTGACCTTGATCAATGTCTGTTCCTGAGCAAAATTCATCAAATATTACAAGGCT
ATCTTTTGTAGTATGTTTTAAAATATAAGAAATATTGCTCATATGGCTTGAAAAAGTTGAAAGAGAATTA
GAAATTGACTGCTCATCACCAATGTCAATAAAAATGTTATCAAAAATTTTAAAAGTGCTAGACTCACCAA
CAACAATAGGGATCCCAAATTGAAACATTGCACTAAGTAGTCCAATTGTCTTTAAAGTTACCGTTTTTCC
ACCAGCATTAGGACCAGTAATAATTACAACACGATTCTCAGCAGGAGTAAAAGTTATTGCCTTTGAATCC
TTTAACAAAGGATGGTGTGCATCAAAAATATTTAATACATTTGAAATCTCGGGAAATACCCCTTTAGTTT
TGATTCCATAAATCGCTCGAGCTTTTAAAGAATCATAATACAAAAAATTATTATAAAGGTTATCTAAAAG
AACAATGTTGCTATGAACTTTAGCAGAAAGATTTCGTAAAATTTTTAAAATTATTCTTTCTTTTTCTAAG
CTCAAATAATTTAACCTGTTGTTAGCATTTACAATATCGTTTGGCTCAATATAAAATGTTTCACCTGATG
ACGAAATAGAAATAATATTACCCTTAATTTTGCCTTTAAAATTAGACTTAAGAGCAAGGGTATATTTATT
CGATTTATAACAAACAAAATTAGAAGTCAAATATTCTGCGTTCAAACTAATTATTTTTTTTATCTGATTT
TCAACTCGTCTATTTAAATTTTTAATTTCAAATTCAATCGAATCATATTCTTTTACAACACCACTTTTCA
ATTCAAGAGCATCAACATCTATATGTTCTTTCAATTCATTAAGCAAATTTTTTAGCTCTGGGTTTAAAAA
TAATAAATCAGATAAAATCTGAACATTAAGATGCTTGATATCACTATTTTTATGCAAAAATAAATTTATT
CTTAAAACCTCATCTAAAAACACTATAATATCTCTCAAATTTTCAATAGAAACTCTTGAATTTTCTTTTA
ATAATAATGAAATGGGATATTTTAAACTATTTATAAAAGAATTTGGATATCCTTTGCAACTTTCAAAAAG
CATTCTAATCAGACTTACAAAGGAGAATATTTTCTCTAAACTTTCTTTTGTTTTTAATATTTTTTGATTA
CTTAGTAAATTAACAGTATCCGGATTAGAAACGTATTTAGATACTAAAGATAAAATTTCATAAAAGTCAA
TATTTTTTAAATATTTATCTTGTTCATCTTGCA
Protein Sequence 
>gi|15594444|ref|NP_212232.1| recombination and DNA strand exchange inhibitor protein [Borrelia burgdorferi B31]
MQDEQDKYLKNIDFYEILSLVSKYVSNPDTVNLLSNQKILKTKESLEKIFSFVSLIRMLFESCKGYPNSF
INSLKYPISLLLKENSRVSIENLRDIIVFLDEVLRINLFLHKNSDIKHLNVQILSDLLFLNPELKNLLNE
LKEHIDVDALELKSGVVKEYDSIEFEIKNLNRRVENQIKKIISLNAEYLTSNFVCYKSNKYTLALKSNFK
GKIKGNIISISSSGETFYIEPNDIVNANNRLNYLSLEKERIILKILRNLSAKVHSNIVLLDNLYNNFLYY
DSLKARAIYGIKTKGVFPEISNVLNIFDAHHPLLKDSKAITFTPAENRVVIITGPNAGGKTVTLKTIGLL
SAMFQFGIPIVVGESSTFKIFDNIFIDIGDEQSISNSLSTFSSHMSNISYILKHTTKDSLVIFDEFCSGT
DIDQGQALAISILEYLININSYVLISTHYNALKYFAYTHEGVVNASMRMDLETMQPNYNLIFSIPGESYA
FNVASKALIDRSIVIRANEIYSSQKTEINEILEKLIEKEKDLLLIKESMDKKLIQIELQEKELENFYQDL
LLREKNIETKLLNEQNEFLKNSRKVLENLVREIKEGNINVAKNKAFISDLEKNVDLKTNKVNSLNNKRNV
VADFKIGDKVRIVNSNAKGKIVGISKKKITVNVGAFNVSVSSSEISLENFKEKKENGKNFNFSIDYNKEN
LLSFTIDIRGMRSVDALDFLNKKIDNIILNGINKFEIIHGKGEGHLMREVHNLLKELKFIRKYYFAHPSD
GGSGKTIVEI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mutant showed attenuated virulence in C3H/HeN mice (Lin et al., 2009).
COG COG1193L, under L: Replication, recombination and repair
References
Lin et al., 2009: Lin T, Gao L, Edmondson DG, Jacobs MB, Philipp MT, Norris SJ. Central role of the Holliday junction helicase RuvAB in vlsE recombination and infectivity of Borrelia burgdorferi. PLoS pathogens. 2009; 5(12); e1000679. [PubMed: 19997622].