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ruvB

Victor ID 4190
Gene Name ruvB
Sequence Strain (Species/Organism) Borrelia burgdorferi B31
NCBI Gene ID 1194858
NCBI Protein GI 15594368
Locus Tag BB0022
Genbank Accession AE000783
Protein Accession NP_212156
Other Database IDs UniProtKB-ID: RUVB_BORBU
UniRef100: UniRef100_P70828
UniRef90: UniRef90_Q0SPE2
UniRef50: UniRef50_B2S1L1
UniParc: UPI0000057303
EMBL: Y08885
EMBL: AE000783
EMBL-CDS: CAA70097.1
EMBL-CDS: AAC66410.1
RefSeq_NT: NC_001318.1
EnsemblGenome: EBBORG00000008673
EnsemblGenome_TRS: EBBORT00000008674
EnsemblGenome_PRO: EBBORP00000008004
GenomeReviews: AE000783_GR
KEGG: bbu:BB0022
NMPDR: fig|224326.1.peg.406
TIGR: BB_0022
HOGENOM: HBG339960
OMA: EKFDGGP
ProtClustDB: PRK00080
BioCyc: BBUR224326:BB_0022-MONOM
Taxonomy ID 224326
Gene Starting Position 21057
Gene Ending Position 22100
Gene Strand (Orientation) -
Protein Name Holliday junction DNA helicase RuvB
Protein pI 4.92
Protein Weight 37417.17
Protein Length 347
Protein Note promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
DNA Sequence 
>gi|15594346:21057-22100 Borrelia burgdorferi B31 chromosome, complete genome
ATTAAAATGAAACTCTTTGGTTTTCATTAAGACCATCCTCTTTCATCTCTAAGTTTAAGTGAAGGTATGC
AAACTCAGTAGCTTTACGACCTCTGTGAGTTCTACTGATAAATCCTTTCATAATTAAATAAGGCTCATAA
AAGTCTTCAAGAGAATCTGCTGTTTCTCCTACAGAAATAGCTAAAGTATCAACACCTACAGGTCCTCCAT
TAAATTTCAATATTAAACTTCTTAAAATATTTCTATCTTGCTCATCAAGGCCTTCCCCATCAATTCTAAG
CATTTCAAGCCCAATTGAAACAATATCACTTGTAATAACCAAACTTCCAGTTACCTGAGCAATATCTCTT
ATTCGTCTTAAAAGTCTATTTGCTATACGAGGAGTCCCTCTTGAGCTTCTTGCAAGAAGAAAAGCAGCAT
CCTCTTCTATTTCAATATTTAAAATAAGAGAATTTCTCTTTATTATCTCAACAAGCTCTATTTCACTGTA
AAGTTCAAATCTTGCAGTAATTCCAAATCTCGCATAAAGTGGAGATGTTACTTTTCCTGGTTTAGTAGTA
GCTCCAATCAATGTGAATTTTGGAAGTGGCATTCGAACAGTTCTTGCATTGGCTCCTTGCCCTATTACCC
AATCCAGCTCATAATCTTCCATGGCAATGCAAAGCATTTCTTCTATTATTGGTCTGAGCCTATGTATTTC
ATCAATAAATAAAACACTCTTCTCATCAAGACCTGTTAAAATTCCAATAATATCTTTTGGTTTGTCAAAA
GCCGGAGCTGAAGTAATCTTAATAGAAGCATTCATCTCAAAGGCAATAATACTTGCAAGAGTGGTTTTCC
CAAGACCCGGTGGGCCACTTAAAAACACATGATCTAGAGCCTCATCTCTCTCTTTAGAAGCTCTTATGAA
AATACTAAGGGTTTCTTTAACATTAACCTGACCTTTAAAATCTTCAAAAACTTTAGGCCTAAGCTCATTT
TCACTCTTATCATATAAATAATTTTCATTAGAGCTTAAAAAGCTTATACTATTTTCGTCTTTCA
Protein Sequence 
>gi|15594368|ref|NP_212156.1| Holliday junction DNA helicase RuvB [Borrelia burgdorferi B31]
MKDENSISFLSSNENYLYDKSENELRPKVFEDFKGQVNVKETLSIFIRASKERDEALDHVFLSGPPGLGK
TTLASIIAFEMNASIKITSAPAFDKPKDIIGILTGLDEKSVLFIDEIHRLRPIIEEMLCIAMEDYELDWV
IGQGANARTVRMPLPKFTLIGATTKPGKVTSPLYARFGITARFELYSEIELVEIIKRNSLILNIEIEEDA
AFLLARSSRGTPRIANRLLRRIRDIAQVTGSLVITSDIVSIGLEMLRIDGEGLDEQDRNILRSLILKFNG
GPVGVDTLAISVGETADSLEDFYEPYLIMKGFISRTHRGRKATEFAYLHLNLEMKEDGLNENQRVSF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mutant showed attenuated virulence in C3H/HeN mice (Lin et al., 2009).
COG COG2255L, under L: Replication, recombination and repair
References
Lin et al., 2009: Lin T, Gao L, Edmondson DG, Jacobs MB, Philipp MT, Norris SJ. Central role of the Holliday junction helicase RuvAB in vlsE recombination and infectivity of Borrelia burgdorferi. PLoS pathogens. 2009; 5(12); e1000679. [PubMed: 19997622].