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YPTS_4221

Victor ID 4165
Gene Name YPTS_4221
Sequence Strain (Species/Organism) Yersinia pseudotuberculosis PB1/+
NCBI Gene ID 6261902
NCBI Protein GI 186897510
Locus Tag YPTS_4221
Genbank Accession CP001049
Protein Accession YP_001874621
Other Database IDs UniProtKB-ID: B2KAF0_YERPB
UniRef100: UniRef100_P08538
UniRef90: UniRef90_P08538
UniRef50: UniRef50_P15273
UniParc: UPI00000D1266
EMBL: CP001049
EMBL-CDS: ACC91164.1
RefSeq_NT: NC_010635.1
GenomeReviews: CP001049_GR
KEGG: ypb:YPTS_4221
HOGENOM: HBG299062
OMA: SAHEIAN
ProtClustDB: CLSK862151
Taxonomy ID 502801
Plasmid No pYPTS01
Gene Starting Position 10230
Gene Ending Position 11636
Gene Strand (Orientation) -
Protein Name protein-tyrosine phosphatase YopH
Protein pI 8.84
Protein Weight 47198.12
Protein Length 468
Protein Note PFAM: tyrosine specific protein phosphatase; Protein-tyrosine phosphatase YopH~SMART: Protein-tyrosine phosphatase, catalytic~KEGG: yps:pYV0094 YopH; putative protein-tyrosine phosphatase Yop effector
DNA Sequence 
>gi|186897495:10230-11636 Yersinia pseudotuberculosis PB1/+ plasmid pYPTS01, complete sequence
ATTAGCTATTTAATAATGGTCGCCCTTGTCCTTCAGCCAACTTAATCAGAACATCAAGTTGCTCATCTTT
TTGTACCATAATACCATTTCTTTGTACTCGCATTTGGCTGACCATATCTTCTACGCTTAACTGACTATTA
CGACTATCATTCATGCACATTGCGCCAATCAGTTGCGCAGTACGGCCAACACCCGCACGGCAATGTATTA
CCGGCCGTAATTTGGAGTCATCTCCTACCGCTGAACTTCCTTTGCTTTCATACATATTGCGTTTTGTTTC
TGCTGTTTGATCTACCAGTGAAGCGAGTGCCTTGGTAACTTCAGAGCTGACTGCGGTCTGATCGGGCCAA
TTGCCAACATGAACCACAGGAACAGAGATTGTTTTTTGACCCGCTTCACGAATCGTTAAAGTATACATAT
CTGCCATAATCCCGTCACCGAGACCAACTTGCTGAGTCATTTTAGACTCTACAGTGATACTGCCATAGGT
ACCACTCTGGCGGAAATAATCTGGCATACCGAATCTTTGATTGGCTATCTCAGAACTGGACGCTAAAACA
GCCAACACTGGCGTTCGGTTTTCTGCCAGCATACGGAAATGGCTTTCAAGTTGAGATTGTAGCGGATACT
GGCACGCTATGGTACGAGTGTTACCGACCTGGATGTAATTGGCATTAAGATCGGCGCGTACTGCGGTTTG
CCGACAGCATTGAATATCTCTAAATCGGTTTAGCTTTTCACCGCCGCAGGCTTGTAAGTAACGCGGATCA
TTCGTTGCTGGCGCCAGCGTATTGCGCAATGTGGTGAGGCGGCTGCTGAGTTCTGCGCGCGCTTCTGGGC
CATAAGGAGAAACAGTGCTTGGTGCGGTGGCTCTGGCTTCGCCAGCCCCGTGATGGCCAGAAGTGTGTGG
TCGTTCACGCGGTGGCAACGGTGGAGTTCTGGGGTCTAGATGTGAACGCAGTCCTTCACGCACCGGGGTT
CCCGGTGCGTGAAGGGCTGAATGTGAATGAGATGATACATGCCCCCTCGCTCCCGACTCTTGTCGCAATG
CGGCCTCCAACAGCACTTTGGCGTCTTGTAGTGTCATTTGGTCGCTACGTAAACTGACAAGTACACTATT
ACCATTGCCGACACTTCTTAAGTCATAATTATTCAAATTATGCTTTACCGTACTTTGCAATAGCTTAGCG
GTATCTTCTTGAGTTAGAACAACATTTGCTACGTGGCTTAGTACAGTTTGAGCAAATACTTTTTCTGACT
CTCTGGCACCACTGGCTATGGTCAAACCTTGAAAGGTAGTTTCTTTATTGGCAGCAACGTTACCTCTTAA
TTTCCCGGTACAATCACCGCTCTCTTGCTGCACCAATCGAGATACCTGACGATGAAGATCGCTTAATGAT
AAGTTCA
Protein Sequence 
>gi|186897510|ref|YP_001874621.1| protein-tyrosine phosphatase YopH [Yersinia pseudotuberculosis PB1/+]
MNLSLSDLHRQVSRLVQQESGDCTGKLRGNVAANKETTFQGLTIASGARESEKVFAQTVLSHVANVVLTQ
EDTAKLLQSTVKHNLNNYDLRSVGNGNSVLVSLRSDQMTLQDAKVLLEAALRQESGARGHVSSHSHSALH
APGTPVREGLRSHLDPRTPPLPPRERPHTSGHHGAGEARATAPSTVSPYGPEARAELSSRLTTLRNTLAP
ATNDPRYLQACGGEKLNRFRDIQCCRQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTP
VLAVLASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVH
VGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSAVGDDSKLRPVIHCRAGVGRTAQLIGAMCMN
DSRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: yopH mutant is attenuated in mice (Deleuil et al., 2003).
COG COG5599T, under T: Signal transduction mechanisms
References
Deleuil et al., 2003: Deleuil F, Mogemark L, Francis MS, Wolf-Watz H, Fällman M. Interaction between the Yersinia protein tyrosine phosphatase YopH and eukaryotic Cas/Fyb is an important virulence mechanism. Cellular microbiology. 2003; 5(1); 53-64. [PubMed: 12542470].