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ilvI from Actinobacillus pleuropneumoniae serovar 3 str. JL03

Victor ID 4144
Gene Name ilvI from Actinobacillus pleuropneumoniae serovar 3 str. JL03
Sequence Strain (Species/Organism) Actinobacillus pleuropneumoniae serovar 3 str. JL03
NCBI Gene ID 5852660
NCBI Protein GI 165976143
Locus Tag APJL_0729
Protein Accession YP_001651736.1
Other Database IDs UniProtKB-ID: B0BP07_ACTPJ
UniRef100: UniRef100_B0BP07
UniRef90: UniRef90_B0BP07
UniRef50: UniRef50_Q89AP7
UniParc: UPI0001637390
EMBL: CP000687
EMBL-CDS: ABY69292.1
RefSeq_NT: NC_010278.1
GenomeReviews: CP000687_GR
KEGG: apj:APJL_0729
HOGENOM: HBG323037
OMA: GAMNEMW
ProtClustDB: PRK06882
BioCyc: APLE434271:APJL_0729-MONOMER
Taxonomy ID 434271
Gene Starting Position 799599
Gene Ending Position 801323
Gene Strand (Orientation) +
Protein Name acetolactate synthase 3 catalytic subunit
DNA Sequence 
>gi|165975457:799599-801323 Actinobacillus pleuropneumoniae serovar 3 str. JL03, complete genome
AATGAAAAAACTTTCCGGAGCAGAAATGGTTGTTCAATCCTTGAAAGACGAAGGCGTAGAGTACGTTTTC
GGCTATCCGGGTGGTTCGGTATTAGATATTTATGATGCGATTCATACGCTGGATAATATTAACCACGTTC
TTGTGCGCCATGAGCAAGCCGCGGTCCATATGGCGGACGGTTACGCTCGCTCAACCGGTAAAGTCGGTTG
TGTATTAGTAACATCCGGTCCCGGTGCAACCAATGCGATCACAGGTATTGCCACCGCTTATGCCGATTCC
GTCCCGCTTGTGATCTTAACCGGTCAAGTGCCTTCCGCTTTAATCGGTACGGATGCTTTCCAAGAATGCG
ATATGCTCGGTATTTCACGCCCTGTGGTTAAACACAGTTTTATGATCAAAAATCCGGAAGATATTCCTTC
AATAATCAAAAAAGCCTTTTATATTGCTTCAACCGGTCGCCCCGGTCCGGTCTTAATTGATATTCCGAAA
GATATGGTAAATCCGGCGAATAAATTTACCTATGAATATCCGAAAGAAGTCTCACTACGTTCATATAACC
CGACCGTACAAGGCCATAAAGGGCAAATTAAAAAGGCATTAAAAGCCCTATTAGTGGCAAAAAAACCGGT
TTTATACATTGGTGGAGGGATTATCTCTGCGGAATGTGCAACGCAACTTACCGACTTTGCAACGAAGTTA
AACTTACCGGTAACCAGTTCGTTAATGGGCTTAGGCGCTTTCCCTGCATCAAACAAACAATTTTTAGGTA
TGCTCGGTATGCACGGTACTTACGAAGCGAATAACGCAATGCACGAAAGCGATTTGATTCTCGGCATTGG
CGTACGTTTTGATGACCGTACCACGAATAATTTAGCAAAATATTGCCCGAATGCAAAAGTCATTCACGTG
GATATTGATCCGGCTTCTATTTCAAAAACCGTTCCGGCTTATATTCCGATTGTGGGTAGCGCAAAAAATG
TCTTGGAAGAATTTCTCAGCCTTTTAGAAGAAGAAAATCTTGCAAAAAATCAAGCGGATTTGACCGCTTG
GTGGCAACAGATTAATGAATGGAAAGCTCGTCAGTGCTTAAATTTTGAAGTAAGTAAAGATGTAATCAAA
CCGCAGCAAGTCATTCGATTAATTCATAAAATTACCAATGGTGATGCCTATGTTGCTTCGGATGTCGGTC
AGCACCAAATGTTTGCCGCACTCCATTATCCGTTTGAAAAACCTCGTCGCTGGATCAACTCGGGCGGAGC
CGGTACCATGGGATTCGGTTTACCGGCAGCAATCGGCGTAAAATTCGCCCATCCGGAAGCAACTGTAGTA
TGTGTAACCGGTGACGGCTCGATTCAGATGAATATTCAAGAGCTTTCTACGGCGAAACAATATGATACGC
CGGTTGTGATTGTGAGCTTAAACAATCGCTTCTTAGGTATGGTGAAGCAGTGGCAAGATCTGATCTACTC
CGGTCGCCATTCACAGGTATATATGAATTCACTGCCTGATTTTGCCAAATTAGCCGAAGCTTACGGTCAT
GTCGGCATTACGATTGATCACCCGAACGAATTGGAAGAAAAACTCACCCAAGCCTTTGCTATCAAAGACA
AATTAGTGTTTGTCGATGTAAAAGTAGATGAAACCGAACACGTTTACCCGATGCAAATTCGCGGCGGTGC
GATGAATGAGATGATTTTAAGCAAAACGGAGAGAACAGATGCGTA
Protein Sequence 
>gi|165976143|ref|YP_001651736.1| acetolactate synthase 3 catalytic subunit [Actinobacillus pleuropneumoniae serovar 3 str. JL03] MKKLSGAEMVVQSLKDEGVEYVFGYPGGSVLDIYDAIHTLDNINHVLVRHEQAAVHMADGYARSTGKVGCVLVTSGPGATNAITGIATAYADSVPLVILTGQVPSALIGTDAFQECDMLGISRPVVKHSFMIKNPEDIPSIIKKAFYIASTGRPGPVLIDIPKDMVNPANKFTYEYPKEVSLRSYNPTVQGHKGQIKKALKALLVAKKPVLYIGGGIISAECATQLTDFATKLNLPVTSSLMGLGAFPASNKQFLGMLGMHGTYEANNAMHESDLILGIGVRFDDRTTNNLAKYCPNAKVIHVDIDPASISKTVPAYIPIVGSAKNVLEEFLSLLEEENLAKNQADLTAWWQQINEWKARQCLNFEVSKDVIKPQQVIRLIHKITNGDAYVASDVGQHQMFAALHYPFEKPRRWINSGGAGTMGFGLPAAIGVKFAHPEATVVCVTGDGSIQMNIQELSTAKQYDTPVVIVSLNNRFLGMVKQWQDLIYSGRHSQVYMNSLPDFAKLAEAYGHVGITIDHPNELEEKLTQAFAIKDKLVFVDVKVDETEHVYPMQIRGGAMNEMILSKTERTDA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ilvI mutant is attenuated in pigs (Subashchandrabose et al., 2009).
COG COG0028EH, under E: Amino acid transport and metabolism; H: Coenzyme transport and metabolism
References
Subashchandrabose et al., 2009: Subashchandrabose S, LeVeque RM, Wagner TK, Kirkwood RN, Kiupel M, Mulks MH. Branched-chain amino acids are required for the survival and virulence of Actinobacillus pleuropneumoniae in swine. Infection and immunity. 2009; 77(11); 4925-4933. [PubMed: 19703979].