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ascC

Victor ID 4095
Gene Name ascC
Sequence Strain (Species/Organism) Aeromonas salmonicida subsp. salmonicida A449
NCBI Gene ID 4999328
NCBI Protein GI 145301440
Locus Tag ASA_P5G057
Genbank Accession DQ386863
Protein Accession YP_001144279
Other Database IDs UniProtKB-ID: Q27RH9_AERS4
UniRef100: UniRef100_Q27RH9
UniRef90: UniRef90_Q27RH9
UniRef50: UniRef50_Q01244
UniParc: UPI00005191D4
EMBL: DQ386863
EMBL: CP000646
EMBL-CDS: ABD48952.1
EMBL-CDS: ABO92531.1
RefSeq_NT: NC_009350.1
GenomeReviews: CP000646_GR
KEGG: asa:ASA_P5G057
eggNOG: COG1450
HOGENOM: HBG299041
OMA: GGRTQIK
ProtClustDB: CLSK862141
BioCyc: ASAL382245:ASA_P5G057-MONOMER
Taxonomy ID 382245
Plasmid No 5
Gene Starting Position 58725
Gene Ending Position 60578
Gene Strand (Orientation) -
Protein Name AscC protein
Protein pI 4.8
Protein Weight 62840.2
Protein Length 617
DNA Sequence 
>gi|145301385:58725-60578 Aeromonas salmonicida subsp. salmonicida A449 plasmid 5, complete sequence
CTCATCGGGTAGCGCCCTCATTGCCCGCCTGCACACACCAGCTGGCGGCCGGTGTACATTTTTGATCCTT
GTTCATTTCGACCAGACGCCACCCCAGCTCATTGCCCATCCGGCACTGAGTGAGGGACGAGCTCTTACCC
CCCTGACGCAGCAGCTGCTGCACGTCACGGGCTGCAGCCAGCGGCTGGCATTGCGCGCCCCCCAGCACCT
TGCCAAGGGAGAGACTCTGATTGGAGATTTCATCAGCCCCGAGCACCCCGGCGCGCAGATCCTGACCATT
GCCGAGGGCCAGATAGTGGGCAATACCGTCATCAATCAGACGAGGCTCGATGATAAATAGCCGCACTGAG
CGACGGGTCTGGGTGTCCTTACTACGGAACAGCGCCCCCAGATAAGGGATGTCACCAAGGAAGGGCACCT
TGCTCAGGTTCTCGCTCATCTCGTCGCGGTAGATACCGCCTATCAGCAGGCTCTGGCCGTGGCCGACCCG
GGCGATGGTATCGACCACGGTACGACTGATGGTAGGAATGCCATCGGCCCCCGCACTGTTGGGTTTCTGG
TTGCCATCCTCGATATGGAGGCTCAGGCTGATCTCGGGTCTGTCACCCATCTGGATCACCCGGGGGGTCA
TCCGCAACATGGTGCCGTAGGTGATCCCCTGCAGCTCGGCCACCCGCTCACCGCTGATCTTCACGTAATA
AGTCTCGCTGTGGTCGATCACCGCCTGGGTGTTCTCCTGGGTCAGCAAGGTCGGGCGGGAGACCACCTGG
GCATTGCCTTCGTTTTCCAGCAGATTGACTCGGGCCAGCAGATAGTCGAGCCCTTTGGAATCCACCAGAC
TGCCGAGCGCGGCGCCCCCTTCAATCCCCTTGCGATCGCCGGTGGTCTTGATAATCACCTGCTGGTTAGA
ACCGGTGCGGATCCCCACTCGCCAATCCACCCCCAGCTGGGAGAGATCCTCGGCATTGATATCGATGATG
GAGAGCGCCACCTCAATGCGGGCCGCCGGTTTGTCGAGCGCGGCGATCAACTTGCCGTACATCGCCATCC
GCTCCGGAGCATCGCGCACGATCACCGCATTGAGGGAAGGATCGGCCTGCACGATGGCCTGACCGGAGGT
GGCTGTCGCTGCCTTGTTACCCTCGCCGTTGACCATCTGCACGCCAGCATCGCTCAGCAGCTTGGCCAAA
ATGGTCGCCACACCGGGCGCCGCCACATCGGTATCGCGGTACTGGATGGAGCGATCGGTAGCCGAGGCGT
ACTTGAGGGGAAAGATCTCGATGGCCAGCGGCCCGGTCTTCTCGCTGCGTAGCTGGGACTGTTGCTCCAA
TGCCAGCGCGGTCTGTTCGATCAATTCAAGGTAACGGGGCGGTCCGGAGACATAGAGCAGCCTGTTATCC
GCATCGGGGCGCCAGCCAAAACGGGGCTCCCAGATCCCGGCTCGTTGAAGCGCCTGTTTGAGTTCTGCTG
CGCCAGTCTGCTCCAGATTGATGAGACGGGACTGCACTTCGCTGTTCTTGAAGACGTAGAGCACATTGCC
GTCGTAGTACCAGACCAGGTTGTAGAGGGAGGAGAGCTGCTGCAAAAAGGCGAGCGGCTCGTCATGCTCA
AACTGGCCGTTGACCTGATCGTTGACCTTGTCGCTGACTACCACGGAAACCTCGTAGTTGGCACCGAAGT
TGACCAGCACGTCGCGCAGACTCTCCCCTTCTGCCACATAACTGTAAGGCATGGGCACCCAGTCCAGCTC
CTGTGCCATGGCGGGACGCTGCCACGCCATCACGGCGAGGCAGATCCACAACAGGGGACGCAGCAGGGGT
TGCACGCTCAAGGGTGCCATATCATCTGTCTCCA
Protein Sequence 
>gi|145301440|ref|YP_001144279.1| AscC protein [Aeromonas salmonicida subsp. salmonicida A449]
METDDMAPLSVQPLLRPLLWICLAVMAWQRPAMAQELDWVPMPYSYVAEGESLRDVLVNFGANYEVSVVV
SDKVNDQVNGQFEHDEPLAFLQQLSSLYNLVWYYDGNVLYVFKNSEVQSRLINLEQTGAAELKQALQRAG
IWEPRFGWRPDADNRLLYVSGPPRYLELIEQTALALEQQSQLRSEKTGPLAIEIFPLKYASATDRSIQYR
DTDVAAPGVATILAKLLSDAGVQMVNGEGNKAATATSGQAIVQADPSLNAVIVRDAPERMAMYGKLIAAL
DKPAARIEVALSIIDINAEDLSQLGVDWRVGIRTGSNQQVIIKTTGDRKGIEGGAALGSLVDSKGLDYLL
ARVNLLENEGNAQVVSRPTLLTQENTQAVIDHSETYYVKISGERVAELQGITYGTMLRMTPRVIQMGDRP
EISLSLHIEDGNQKPNSAGADGIPTISRTVVDTIARVGHGQSLLIGGIYRDEMSENLSKVPFLGDIPYLG
ALFRSKDTQTRRSVRLFIIEPRLIDDGIAHYLALGNGQDLRAGVLGADEISNQSLSLGKVLGGAQCQPLA
AARDVQQLLRQGGKSSSLTQCRMGNELGWRLVEMNKDQKCTPAASWCVQAGNEGATR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ascC mutant was less invasive of Atlantic salmon anterior head kidney leucocytes (AHKL) and had less survival than the wild type strain (Fast et al., 2009).
COG COG1450NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport
References
Fast et al., 2009: Fast MD, Tse B, Boyd JM, Johnson SC. Mutations in the Aeromonas salmonicida subsp. salmonicida type III secretion system affect Atlantic salmon leucocyte activation and downstream immune responses. Fish & shellfish immunology. 2009; 27(6); 721-728. [PubMed: 19751835].