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aexT

Victor ID 4091
Gene Name aexT
Sequence Strain (Species/Organism) Aeromonas salmonicida subsp. salmonicida A449
NCBI Gene ID 4998373
NCBI Protein GI 145301097
Locus Tag ASA_4266
Genbank Accession CP000644
Protein Accession YP_001143938
Other Database IDs UniProtKB-ID: Q27RI2_AERS4
UniRef100: UniRef100_Q93Q17
UniRef90: UniRef90_Q93Q17
UniRef50: UniRef50_Q93Q17
UniParc: UPI00000BD775
EMBL: DQ386860
EMBL: CP000644
EMBL-CDS: ABD48949.1
EMBL-CDS: ABO92190.1
RefSeq_NT: NC_009348.1
GenomeReviews: CP000644_GR
KEGG: asa:ASA_4266
eggNOG: NOG149636
HOGENOM: HBG298842
OMA: TNGEYQH
ProtClustDB: CLSK689870
BioCyc: ASAL382245:ASA_4266-MONOMER
Taxonomy ID 382245
Gene Starting Position 4562301
Gene Ending Position 4563728
Gene Strand (Orientation) -
Protein Name TTSS effector protein AexT
Protein pI 4.9
Protein Weight 47425.61
Protein Length 475
DNA Sequence 
>gi|145297124:4562301-4563728 Aeromonas salmonicida subsp. salmonicida A449, complete genome
GTCACGCCAAATCGAGCCCGCGCATCTTCAGACGGATATCTTGCTCTTGCGGCTTGTCGGCACCGCCCGC
TCCTCTTGCCAGATCCAGCCCGTCCAGCAGCCCCTTGCTGTGGCCGCTTTGTTCCCCCAGCGAGGCCTCT
TCCAGTACCCGCCGGGTGACGCCCCGTTCATCTTTGGCACTGAGCAATACCCGCATATCAGTCTCTTTGT
TATAGAGGATCTCCTGCTCGTCACCTTCAACGGATATGTCGCTGACATCGATCCCCGAGCGGCCAAATAT
CGTGGATATGGAGCCTGAACCACCAAAGTTGGTTGCCACCTTGGGATCCCGAGAGGTGGAAAGATAAGCG
ACATCATGACCGACTTGCCCCTCTGCCACCTCGTTGAACGCATCGCCGCCGTGGGTACCGCGGAAGGTCT
TGATCAACTGCTCGGTGGGGGTACTTTTCTCAAAAGCGGTGGACATACCCTGATCGATCAACGCTTGCCC
TGCATCCAGCTGCTTTTCCTGACGCAGCGAGCGATTCAGGTGCTGGTATTCGCCGTTGGTGTAGAGCCCA
AGCGCCATCACTTCAGCATCGCTGTAAGTACCGTGGGGCTGTTCACCCAGATATTGCTCGGCCTCCAGGC
CGAATTGCTCCTGCAAGCCCTCTGCCAGCGCCTTGTCGGCAGGCTCAACGTTAACTTCGCTCTCACCGCT
TTGGAGCGGCGCCACAGCGGCCGCTGTGGTCGCGCTTCGCGCCGGTTCGCCAGCAACTTCTGCCTTTACA
GCGCGCTGCAGGTCGGCAACTTCACCCATCGCGGTGTGTAGCTGGCTCATAGCCTCCTTCAACAGTTCGG
GGGGGGCGCTGGTGAGCAGCTCGGTCACCTTGCCGCCTACCGACCCCCACTGCTGGAGCGGGATACCGGC
GATGGGGCGGGCCAGCAGCCCGGTAGCCAACTCCCGGAGTTGCGGTTGCTGAGATCCTATGACAACGGCC
TGCAACGCGGTGCAGAGAGAGCGCAGGGGGCCATTGCCGGTCGCCAGACTGGCGTGATCCTTGCCCAATT
GTTCGCCTGTGATGTTGTTCAACACGTCCGCCTTGGCGAAGCCACCCAGCGAGCTACCAAATGCAGCCTG
CTTCATCAGTCGCTGAAGATCCTCGGGGGAAACGGCGGTTTGCGCCTTCGGCGCAGCGGCACGCTTGTCC
GTCCCCAGCAGGTTGCTGATCCACTCTTTGATGGCCACGAACGGGCGGGCCAGCTGGGCCCCCAGTCGCG
AGAGCAGCCCCTGCCCTTTTTGCGGTTCGCTGCGACTGCCCAGCAGGATCGCATCTTGTCCGGTGGCGAC
CTGACGCGCCTCCATCTGACCCATCCGGCCAACTCCGGTCGTGGCATCACTGTGGTGAGCGACGGCCTGT
GTGCCGACGGTGTTTGCTTGAATCTGCA
Protein Sequence 
>gi|145301097|ref|YP_001143938.1| TTSS effector protein AexT [Aeromonas salmonicida subsp. salmonicida A449]
MQIQANTVGTQAVAHHSDATTGVGRMGQMEARQVATGQDAILLGSRSEPQKGQGLLSRLGAQLARPFVAI
KEWISNLLGTDKRAAAPKAQTAVSPEDLQRLMKQAAFGSSLGGFAKADVLNNITGEQLGKDHASLATGNG
PLRSLCTALQAVVIGSQQPQLRELATGLLARPIAGIPLQQWGSVGGKVTELLTSAPPELLKEAMSQLHTA
MGEVADLQRAVKAEVAGEPARSATTAAAVAPLQSGESEVNVEPADKALAEGLQEQFGLEAEQYLGEQPHG
TYSDAEVMALGLYTNGEYQHLNRSLRQEKQLDAGQALIDQGMSTAFEKSTPTEQLIKTFRGTHGGDAFNE
VAEGQVGHDVAYLSTSRDPKVATNFGGSGSISTIFGRSGIDVSDISVEGDEQEILYNKETDMRVLLSAKD
ERGVTRRVLEEASLGEQSGHSKGLLDGLDLARGAGGADKPQEQDIRLKMRGLDLA
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: ADP-ribosylating toxin Aeromonas exoenzyme T (AexT) results in depolymerization of the actin cytoskeleton and cell rounding of fish cells (Fehr et al., 2007).
COG COG5585T, under T: Signal transduction mechanisms
References
Fehr et al., 2007: Fehr D, Burr SE, Gibert M, d'Alayer J, Frey J, Popoff MR. Aeromonas exoenzyme T of Aeromonas salmonicida is a bifunctional protein that targets the host cytoskeleton. The Journal of biological chemistry. 2007; 282(39); 28843-28852. [PubMed: 17656370].