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hemA from Actinobacillus pleuropneumoniae L20

Victor ID 4065
Gene Name hemA from Actinobacillus pleuropneumoniae L20
Sequence Strain (Species/Organism) Actinobacillus pleuropneumoniae L20
NCBI Gene ID 4849853
NCBI Protein GI 126207888
Locus Tag APL_0404
Protein Accession YP_001053113.1
Other Database IDs UniProtKB-ID: HEM1_ACTP2
UniRef100: UniRef100_A3MZC2
UniRef90: UniRef90_A3MZC2
UniRef50: UniRef50_Q65SX9
UniParc: UPI0000397C31
EMBL: CP000569
EMBL-CDS: ABN73508.1
RefSeq_NT: NC_009053.1
GenomeReviews: CP000569_GR
KEGG: apl:APL_0404
eggNOG: COG0373
HOGENOM: HBG732626
OMA: GPILNRL
ProtClustDB: PRK00045
BioCyc: APLE416269:APL_0404-MONOMER
Taxonomy ID 416269
Gene Starting Position 459205
Gene Ending Position 460515
Gene Strand (Orientation) -
Protein Name glutamyl-tRNA reductase
DNA Sequence 
>gi|126207488:459205-460515 Actinobacillus pleuropneumoniae L20, complete genome
GTTATTGTTCTTCTAATTTTAAGGCTTTAGAAAAACTCTGAAGTCCTTGAGAATTTCCGCTCTTCGCCAT
AGCCTGTAACGCTTGGGTCGGCACGTGTAATAAGCTGTTGGTCAGTTTATAACTTAGCTCGTTAAGGACT
TTTTCACTATCTTGTCCACTGGTTAAGGCAACTAATGCTTTCGCTAATAGCTCTTGACGAGTTTGCTCGG
CATCTTGGCGATAACGTTTAATCAAATCGCTGGATTGCTGTTGTTTCAGCCATTCAAAGAACGCTTTACA
TTCTTCATCCACAATTTGTGCCGCTTGTTCTGCAGCTTGTTCTCGTTGCGCCATATTACGTTGAATGATA
TGTTGTAAATCATCTACGCTGTAAGAATATACCGCATCCAATTCGCCGGCATTTTCGTCAATATCGCGAG
GAACGGCAATATCAATCAATAACATCGGATCAAACTGGCGTTGTTTCTGTGCGATTTCCACCATTTCTTT
GCTAATCAGCATATCCGGACTGCCGGTAGAACTGATAACGATATCCGCTTGGTTTAAACCGATTTGCAAT
GCGCTTAATGATAAAATTTGCATCGGCGTGTTTAAACGCTCCGCTAACGTTTCCGCACGTTGCGGCGTAC
GGTTGGCGATCATAATGTTTTTCGCGCCGTGCTGAATTAAATAACGCGCGACTAATTCGATGGTTTCGCC
GGCACCGACCAACAAGAAACGCAATTTACCGAAATTATCGAAAATCTGGCGTGCCAAACCGCAAGCGGCA
TAAGCGACCGATACCGCACTTGAACCGATTTCCGTTTCGGAACGCACACGTTTTGCCGTCGAAAAGGTAC
GTTGGAACAGACGGGATAATTTAGTAGAAATATGGCTGTTCTGCGATTGGTAAAAATTCTCGCTATATTG
ATAAGCTTGTTTTACCTGACCTAGAATTTGCGGCTCGCCCAAGATAAGCGAATCTAAACCGCACGCTACT
CGCATTAAATGACGAGCGGATTCCATATTTTGTTTGAAATAAATACATTCGCGTAGTTCATTATGTTCAA
GTTGATGAATTTCGGCAAACCATTCAAAACATTGTTCACGCCATGCGATGTTATCTTCATGTTCTTCTCG
CGGCGTAATTTCCGCATTATGAAAATAAAGCTCTGTTCGGTTACACGTTGAAAGAATGACAACGCTTTCA
GCAAGTGCGCGGTGTTGAATTTGCTCAAAAGCAAGCTGACGTTTTTGATCATCAAACGCCACCTTACTTC
GCAAATTTACCGAGGCCGTTTTATGGTTAATACCAAGTGCTAAAATCGTCA
Protein Sequence 
>gi|126207888|ref|YP_001053113.1| glutamyl-tRNA reductase [Actinobacillus pleuropneumoniae serovar 5b str. L20] MTILALGINHKTASVNLRSKVAFDDQKRQLAFEQIQHRALAESVVILSTCNRTELYFHNAEITPREEHEDNIAWREQCFEWFAEIHQLEHNELRECIYFKQNMESARHLMRVACGLDSLILGEPQILGQVKQAYQYSENFYQSQNSHISTKLSRLFQRTFSTAKRVRSETEIGSSAVSVAYAACGLARQIFDNFGKLRFLLVGAGETIELVARYLIQHGAKNIMIANRTPQRAETLAERLNTPMQILSLSALQIGLNQADIVISSTGSPDMLISKEMVEIAQKQRQFDPMLLIDIAVPRDIDENAGELDAVYSYSVDDLQHIIQRNMAQREQAAEQAAQIVDEECKAFFEWLKQQQSSDLIKRYRQDAEQTRQELLAKALVALTSGQDSEKVLNELSYKLTNSLLHVPTQALQAMAKSGNSQGLQSFSKALKLEEQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: hemA mutant is attenuated in pigs (Sheehan et al., 2003).
COG COG0373H, under H: Coenzyme transport and metabolism
References
Sheehan et al., 2003: Sheehan BJ, Bossé JT, Beddek AJ, Rycroft AN, Kroll JS, Langford PR. Identification of Actinobacillus pleuropneumoniae genes important for survival during infection in its natural host. Infection and immunity. 2003; 71(7); 3960-3970. [PubMed: 12819083].